1887
Volume 2010, Issue 1
  • ISSN: 2220-2749
  • E-ISSN:

Abstract

Abstract

Congenital heart defects (CHD) have a complex etiology in which environmental factors play a key role. High altitude has already been established as a risk factor. Data from the CHD Registry in Riyadh were used to explore the impact of altitude throughout the Kingdom, including the mountain ranges of the south-west; 2,787 Saudi Arabian CHD cases were studied from 104 different cities and villages. Altitude was estimated using a geographical information system. The CHD “burden” was estimated by normalizing the number of CHD cases according to the city population. Cities at both the highest and the lowest altitudes displayed an increased CHD burden, indicating that CHD burden in Saudi Arabia is impacted by at least two different environmental factors — high altitude and coastal proximity. There is also an indication of a separate south-western influence which may reflect a unique cultural or genetic factor.

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2010-12-12
2019-11-18
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References

  1. O’Rahilly R. and Muller F. , (2001). Human embryology and teratology. 3rd editionJohn Wiley and Sons, New York.
    [Google Scholar]
  2. Croen L.A., Shaw G.M., Sanbonmatsu L., Selvin S. and Buffler P.A. , (1997). Maternal residential proximity to hazardous waste sites and risk for selected congenital malformations. Epi. 8:, 347354.
    [Google Scholar]
  3. Moss A.J. , (1992). Clues in diagnosing congenital heart disease. Western J Med. 156:, 4, 392398.
    [Google Scholar]
  4. Stoll C., Alembik Y., Roth M.P., Dott B. and Geeter B. , (1989). Risk factors in congenital heart disease. Eur J Epidemiol. 5:, 3, 382391.
    [Google Scholar]
  5. De la Cruz M.V., Munoz-Castellanos L. and Nadal-Ginard B. , (1971). Extrinsic factors in the genesis of congenital heart disease. British Heart Journal. 33:, 203213.
    [Google Scholar]
  6. Alzamora V., Rotta A., Battilana G., Abugattas R., Rubio C., Bouroncle J., Zapata C., Santa-Maria E., Binder T., Subiria R., Paredes D., Pando B. and Graham G.G. , (1953). On the possible influence of great altitudes on the determination of certain cardiovascular anomalies. Pediatrics. 12:, 259262.
    [Google Scholar]
  7. Miao C.Y., Li W.X., Geng D., Tao L., Zuberbuhler J.S. and Zuberbuhler J.R. , (1988a). Effect of high altitude on prevalence of congenital heart disease. Chinese Medical Journal. 101:, 6, 415418.
    [Google Scholar]
  8. Miao C.Y., Zuberbuhler J.S. and Zuberbuhler J.R. , (1988b). Prevalence of congenital cardiac anomalies at high altitude. JACC. 12:, 1, 224228.
    [Google Scholar]
  9. Mitri W., Sandridge A.L., Subhani S. and Greer W. , (2002). The design and development of an Internet registry for congenital heart defects. Teratology. 65:, 7887.
    [Google Scholar]
  10. Greer W., Sandridge A.L., Al-Menieir M. and Al-Rowais A. , (2005). Geographical distribution of congenital heart defects in Saudi Arabia. Ann Saudi Med. 25:, 1, 6369.
    [Google Scholar]
  11. Al-Tahan A., Buchur J., El Khwsky F., Ogunniyi A., Al-Rajeh S., Larbi E., Daif A. and Bamgboye E. , (1998). Risk factors of stroke at high and low altitude areas in Saudi Arabia. Archives of Medical Research. 29:, 2, 173177.
    [Google Scholar]
  12. Raffa H. and Toonisi T. , (1989). Congenital cardiopathies in Arab children. Indian Heart Journal. 41:, 2, 123126.
    [Google Scholar]
  13. Abbag F. , (1998). Patterns of congenital heart disease in the southwestern region of Saudi Arabia. Ann Saud Med. 18:, 5, 393395.
    [Google Scholar]
  14. Jaiyesimi F., Ruberu D.K. and Misra V.K. , (1993). Pattern of congenital heart disease in King Fahd Specialist Hospital. Buraidah. Ann Saudi Med. 13:, 407411.
    [Google Scholar]
  15. Cedergren M., Selbing A. and Kallen B. , (2002). Geographic variations in possible risk factors for severe cardiac malformations. Acta Paediatr. 91:, 2, 222228.
    [Google Scholar]
  16. Beerman L.B. and Zuberbuhler J.R. , Anderson R.H., Baker E.J., McCartney F.J., Rigby M.L., Shinebourne E.A., Tynan M. Atrial septal defect. Paediatric Cardiology. (2002). Churchill Livingstone, London. 901930.
    [Google Scholar]
  17. Alzamora-Castro V., Battilana G., Abugattas R. and Sialer S. , (1960). Patent Ductus Arteriosus and high altitude. Amer J Cardiol. 5:, 761763.
    [Google Scholar]
  18. Penazola D., Arias-Stella J., Sime F., Recavarren and Marticorena E. , (1964). The heart and pulmonary circulation in children at high altitudes. Pediatrics Oct.. 568582.
    [Google Scholar]
  19. Abushaban L., Al-Hay A., Uthaman B., Salama A. and Selvan J. , (2004). Impact of the Gulf war on congenital heart disease in Kuwait. International Journal of Cardiology. 93:, 157162.
    [Google Scholar]
  20. McMartin K.I. and Koren G. , (1999). Proactive approach for the evaluation of fetal safety in chemical industries. Teratology. 60:, 130136.
    [Google Scholar]
  21. Incardona J.P., Carls M.G., Teraoka H., Sloan C.A., Collier T.K. and Scholz N.L. , (2005). Aryl hydrocarbon receptor-independent toxicity of weathered crude oil during fish development. Environ Health Perspect. 113:, 17551762.
    [Google Scholar]
  22. Kuehl K.S. and Loffredo C.A. , (2003). Population-based study of L-transpositoin of the great arteries: possible associations with environmental factors. Birth Defects Research (Part A). 67:, 162167.
    [Google Scholar]
  23. Cho, Xu , Sammael, X. , You, S.-I. , Cui, M. , Huang, L. , Ma, S. , Padungtod, Y. , Pothier, G. , Niu, C. , Christiani, L. , Smith, T. , Ryan, D. and Wang, T., 1998. Association of petrochemical exposure with spontaneous abortion. 55:31-36.
  24. Abramson J.H. , (2004). WINPEPI (PEPI-for-Windows) computer programs for epidemiologists. Epidemiologic Perspectives & Innovations. 1:, 6
    [Google Scholar]
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  • Article Type: Research Article
Keyword(s): Altitude , Congenital heart defect , Geographical distribution , Saudi Arabia and Toxic exposure
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