1887

Abstract

Abstract

The lymphocytes of healthy adult men occupationally exposed to Domestic Cooking Gas (DCG) were screened for genotoxic damage using the Cytochalasin Block Micronucleus [cytome] (CBMN) Assay. Results obtained, show that there was a significant increase in the the induction of binucleated micronuclei frequency (BNMN) in subjects exposed to DCG as compared with the non-exposed controls, with a 92 percent increase in the degree of induction. There was a positive correlation between the degree of micronuclei induced and the duration of exposure (r2 = 0.78). A higher proliferation rate (1.58 ± 0.3), as calculated using the Nuclear Division Index (NDI) was found in the exposed group as compared with the control group (1.36 ± 0.05).

The observations above suggests that DCG may induce chromosomal damage and cell proliferation in vivo.

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/content/papers/10.5339/qproc.2012.mutagens.3.67
2012-03-01
2019-10-19
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http://instance.metastore.ingenta.com/content/papers/10.5339/qproc.2012.mutagens.3.67
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  • Received: 15 May 2012
  • Accepted: 15 May 2012
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