1887
Volume 2005, Issue 1
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

The purpose of this study is to formulate guidelines for proper surgical management ofphyllodes tumours. It is a disease often misdiagnosed by the pathologist and undertreated by surgeons. We have retrospectively studied 12 patients with histologically proven cystosarcoma phyllodes (CSP). There were 4 benign and 8 malignant lesions, with an incidence of 33.33% vs 66.66% respectively. The treatment was surgical in all patients. The extent of surgery ranged from wide local excision to Modified Radical Mastectomy (MRM). One patient with malignant CSP developed lung metastases (12.5%) and three had recurrences (37.5%). The exact recurrence rate can't be calculated because 5 patients lost follow-up. The results of this study indicates that local excision is safe for benign CSP and all patients with malignant CSP should be treated by mastectomy since there is a high recurrence rate with local excision (37.5 %).

Loading

Article metrics loading...

/content/journals/10.5339/qmj.2005.1.14
2005-06-01
2019-12-08
Loading full text...

Full text loading...

References

  1. Contarini O, Urdaneta LF, Hagan W, Stephenson SE Jr. Cystosarcoma phylloides of the breast: a new therapeutic proposal. Am Surg. 1982; 48::157166.
    [Google Scholar]
  2. Mallebre B, Ebert A, Perez-Canto A, Hopp H, Opril F, Weitzel H. Cystosarcoma phylloides of the breast. A retrospective analysis of 12 cases. Geburtshilfe Frauenheilkd. 1996; 56::3540.
    [Google Scholar]
  3. Ruegg P, Sulser H. Cystosarcoma Phylloides of the breast. Analysis of 58 cases. Schweiz Med Wochenschr. 1975; 105::13461355.
    [Google Scholar]
  4. Eich PD, Diederich S, Eich HT, Micke O, Wagner W. Diagnostic radiation oncology: malignant cystosarcoma phylloides. Strahlenther Onkol. 2000; 176::192195.
    [Google Scholar]
  5. Haberthur F, Torhorst J, Feichter GE. Rare breast tumours. Ther Umsch. 1993; 50::359365.
    [Google Scholar]
  6. Hendrickx P. The mammographic and sonographic clinical picture of cystosarcoma phylloides. Aktuelle radiol. 1992; 2::2631.
    [Google Scholar]
  7. Geppert M, Bachmann FF. Rare Presentations of Cystosarcoma phylloides. Geburtshilfe Frauenheilkd. 1982; 42::732735.
    [Google Scholar]
  8. Browder W, Mc Quitty JT Jr, McDonald JC. Malignant cystosarcoma phylloides. Treatment and prognosis. Am J Surg. 1978; 136::239241.
    [Google Scholar]
  9. Bohme M, Lottage M, Cuno-Klausenitz S. Cystosarcoma phylloides of the breast-2 case reports. Zentralbl Gynakol. 1995; 117::217219.
    [Google Scholar]
  10. Bassler R, Zahner J. Recurrences and meteastases of cystosarcoma phylloides (phylloide tumor, WHO). On the 150th birthday of a contrversial diagnostic concept. Geburtshilfe Frauenheilkd. 1989; 49::110.
    [Google Scholar]
  11. Lee YT, Markland FS. Steroid receptors in sarcomatous lesions. J Surg Oncol. 1979; 11::305311.
    [Google Scholar]
  12. Khanna S, Gupta S, Khanna NN. Sarcomas of the breast: Homogenous or heterogenous? J Surg Oncol. 1981; 18::119128.
    [Google Scholar]
  13. Briggs RM, Walters M, Rosenthal D. Cystosarcoma phylloides in adolescent female patients. Am J Surg. 1983; 146::712714.
    [Google Scholar]
  14. Sheen-Chen SM, Chou FF, Chen WJ. Cystosarcoma phylloides of the breast: a review of clinical, pathological and therapeutic option in 18 cases. Int surg. 1991; 76::101104.
    [Google Scholar]
  15. Cole-Beuglet C, Soriano R, Kurtz AB, Meyer JE, Kopans DB, Goldberg BB. Ultrasound, X-ray mammography and histopathology of cystosarcoma phylloides. Radiology. 1983; 146::481486.
    [Google Scholar]
  16. Schwickerath J, Blessing MH, Wolff F. A rare clinical manifestation of a combination tumour of cystosarcoma phylloides milignum and an intraductal cancer. Geburtshilfe Frauenheilkd. 1992; 52::557559.
    [Google Scholar]
  17. Hunger E, Turk R, Wurster K. Malignant cystosarcoma phylloides and squamous cell carcinoma of the breast. A rare tumor combination. Geburtshilfe Frauenheilkd. 1984; 44::640642.
    [Google Scholar]
  18. El Zawahry MD, Farid M, Abd El Latif A, Horeia H, El Gindy M, Twakal G. Breast lesions in generalized neurofibromatosis: Breast cancer and cystosarcoma phylloides. Neurofibromatosis. 1989; 2::121124.
    [Google Scholar]
  19. Knudsen PJ, Ostergaard J. Cystosarcoma phylloides with lobular and ductal carcinoma in situ. Arch pathol lab med. 1987; 111::873875.
    [Google Scholar]
  20. Hines JR, Murad TM, Beal JM. Prognostic indicators in cystosarcoma phylloides. Am J Surg. 1987; 153::276280.
    [Google Scholar]
  21. Rosai J. Ackerman's Surgical Pathology: Mosby 1996 ISBN 0-8016-7004-4; 1628-1630..
  22. Baczako K, Fischer H. Malignant Metastasizing cystosarcoma phylloides of the breast. Ulm collection of rare tumors: VI. Onkologie. 1984; 7::382384.
    [Google Scholar]
  23. De Leo G, Punzo C, Losacco T, Neri VD, Eredita G, Pitzalis MV. Cystosarcoma phylloides of the breast: Clinical cases. G Chir. 1993; 363:367.
    [Google Scholar]
  24. Wilken H, Rohde E. Course of a malignant Cystosarcoma phylloides. Zentralbl Gynakol. 1991; 113::11891199.
    [Google Scholar]
  25. Zurrida S, Bartoli C, Galimberti V, et al., Which therapy for unexpected phyllode tumour of the breast ? Eur J. Cancer. 1992; 28::654.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5339/qmj.2005.1.14
Loading
  • Article Type: Research Article
Keyword(s): Cystosarcoma phyllodes , phyllodes tumour and sarcoma of the breast
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error