1887
Volume 2014, Issue 1
  • ISSN: 2223-0440
  • EISSN:

Abstract

The cancer of the skin is an increasing problem for public health worldwide. The fair skin populations that are environmentally or occupationally exposed to solar ultraviolet (UV)-radiation are the most affected. Intensive research investigating the molecular mechanisms of skin cancer is ongoing, however the role of noncoding RNAs in the pathology of cutaneous cell carcinoma is not fully understood. Accumulating evidence show that miRNAs play an important role in physiologic, pathologic and carcinogenic processes but their role in epithelial skin cancers (i.e. basal cell carcinoma and squamous cell carcinoma) was to date not sufficiently highlighted. MiRNAs are single-stranded small RNAs which specifically target mRNAs for translational repression and/or mRNA decay. In this review we focus on the latest findings in this area of research reviewing the newest research trends and perspectives.

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2014-03-01
2020-11-27
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