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6 The Anbar 2nd International Medical Conference (AIMCO 2022)
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

The pandemic SARS – CoV2 is a novel virus disease that first appeared in China in December 2019. On February 24, 2020, the disease spread throughout Iraq, and many different studies were conducted on it. This study highlights the procedures for diagnosing COVID-19 and evaluating tools among Iraqi patients through a systematic review of research conducted in Iraq during the past two years (2020–2021).

From March 2020 to December 31, 2021, articles on relevant themes were carefully searched in the main databases: Science Direct, PubMed, Embase, and Iraqi Academic Scientific Journals. Using keywords related to COVID-19 and Iraq yielded a total of 2743 articles. Articles were chosen for this systematic review based on inclusion and exclusion criteria, according to the PRISMA 2020 statement for reporting systematic review. Only Iraqi studies that reported data on diagnostic procedure outcomes were included, with a total of 21 articles chosen.

A total of 21 articles were found to be relevant, which reviewed the biochemical and hematological parameters as diagnostic procedures and tools in Iraqi patients. The biochemical parameters are as follows: triglycerides, cholesterol, APRs, liver functions tests, kidney functions tests, antibodies, cytokines, and minerals. The hematological parameters are as follows: ABO group, red blood cell (RBC) indices, white blood cell (WBC) indices, and platelet indices.

Diagnostic procedures and tools for COVID-19 among Iraqi patients were in agreement with the majority of other global studies. High serum erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), ferritin, -dimer, lactate dehydrogenase (LDH), and cytokines were associated with severe COVID-19 pneumonia and also hypoalbuminemia, lymphocytopenia, and neutrophilia. Biochemical and hematological parameters might be significant indicators for COVID-19 evaluation.

© 2022 Almadhidi, Al Shawi, Mohammed, licensee HBKU Press.
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2022-12-06
2024-05-08
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References

  1. Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet. 2020 Feb 15; 395:(10223):470–3.
     [Google Scholar]
  2. Sohrabi C, Alsafi Z, O’Neill N, Khan M, Kerwan A, Al-Jabir A, et al. World Health Organization declares global emer-gency: a review of the 2019 novel coronavirus (COVID-19). Int J Surg. 2020 Apr; 76::71–6.
     [Google Scholar]
  3. Sarhan AR, Flaih MH, Hussein TA, Hussein KR. Novel coronavirus (COVID-19) outbreak in Iraq: The first wave and future sce-nario. medRxiv. 2020.
     [Google Scholar]
  4. Karim SSA, Karim QA. Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic. Lancet. 2021 Dec 11; 398:(10317):2126–8.
     [Google Scholar]
  5. Almufty HB, Mohammed SA, Abdullah AM, Merza MA. Potential adverse effects of COVID19 vaccines among Iraqi population; a comparison between the three available vaccines in Iraq; a retrospective cross-sectional study. Diabetes Metab Syndr. 2021 Sep-Oct; 15:(5):102207.
     [Google Scholar]
  6. Ma H, Zeng W, He H, Zhao D, Jiang D, Zhou P, et al. Serum IgA IgM nd IgG responses in COVID-1. Cell. Mol. Immunol. 2020; 17:(7): 773–5.
     [Google Scholar]
  7. Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, et al. Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. Lancet Respir Med. 2020 Dec; 8:(12):1233–44.
     [Google Scholar]
  8. Gulhar R, Ashraf MA, Jialal I. Physiology, acute phase reactants. In:StatPearls [Internet][accessed Apr 30, 2021]. Treasure Island (FL):StatPearls Publishing;2022 Jan, PMID: 30137854.
     [Google Scholar]
  9. Vaillant AAJ, Qurie A. Interleukin. In: StatPearls [Internet] [accessed Apr 30, 2021]. Treasure Island (FL):StatPearls Pub-lishing;2022 Jan,PMID: 29763015.
     [Google Scholar]
  10. Mao R, Qiu Y, He JS, Tan JY, Li XH, Liang J, et al. Manifestations and prognosis of gastrointestinal and liver involvement in pa-tients with COVID-19: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2020 Jul; 5:(7):667–78.
     [Google Scholar]
  11. Fan C, Lu W, Li K, Ding Y, Wang J. ACE2 expression in kidney and testis may cause kidney and testis infection in COVID-19 pa-tients. Front Med (Lausanne). 2021 Jan 13; 7::563893.
     [Google Scholar]
  12. Kwo PY, Cohen SM, Lim JK. ACG clinical guideline: evaluation of abnormal liver chemistries. Am J Gastroenterol. 2017 Jan; 112:(1):18–35.
     [Google Scholar]
  13. Abdulla AK, Salman OA, Mahmood AA. Study of some hematological, and biochemical parameters in patients with SARS-CoV-2 in Kirkuk City/Iraq. Sys Rev Pharm. 2020; 11:(11):515–22.
     [Google Scholar]
  14. Ad’hiah AH, Allami RH, Mohsin RH, Abdullah MH, AL-Sa’ady AJR, Alsudani MY. Evaluating of the associa-tion between ABO blood groups and coronavirus disease 2019 (COVID-19) in Iraqi patients. Egypt J Med Hum Gen. 2020; 21:(1):50.
     [Google Scholar]
  15. Ali AM, Ali KM, Fatah MH, Tawfeeq HM, Rostam HM. SARS-CoV-2 reinfection in patients negative for immunoglobulin G fol-lowing recovery from COVID-19. New Microbes New Infect. 2021 Sep; 43::100926.
     [Google Scholar]
  16. Ali KM, Ali AM, Tawfeeq HM, Figueredo GP, Rostam HM. Hypoalbuminemia in patients following their recovery from severe coronavirus disease 2019. J Med Virol. 2021 Jul; 93:(7):4532–6.
     [Google Scholar]
  17. Al-Jaf SMA, Niranji SS, Ali HN, Mohammed OA. Association of apolipoprotein e polymorphism with SARS-CoV-2 infection. Infect Genet Evol. 2021 95::105043.
     [Google Scholar]
  18. Al Meani SAL, Abdulkareem AH, Ibrahim MO, Ahmed MM, Mukhlif MY. Assessment the correlation of D-dimer and ferritin level in patients infected with Covid-19 in Anbar Governorate of Iraq. SRP. 2020; 11:(9):1130–3.
     [Google Scholar]
  19. Al-Nimer MS, Merza TA, Mohammed YMY, Mohammed A. Blood cells indices are determinants of the COVID-19 outcome: a cross-sectional study from Kurdistan region-Iraq. Electron J Gen Med. 2021; 18:(5):em304.
     [Google Scholar]
  20. Haddad MF, Alhamadany AYM, Al-Taie AA. Some biochemical parameters in patients COVID-19 in Mousul city, Iraq. Biochem Cell Archiv. 2021 21::2091–6.
     [Google Scholar]
  21. Hassan BM , Khalil MA, Abdulhameed RA, Al-Anbari AJK. A comparative study on the chest CT scan radiological findings and hematological parameters of COVID–19 and NON–COVID-19 pneumonia patients in Al-Yarmouk Teaching Hospital in Baghdad, Iraq. Medico Legal Update. 2020; 20:(4):833–40.
     [Google Scholar]
  22. Hussein AM, Taha ZB, Malek AG, Rasul KA, Kazim DH, Ahmed RJ, Mohamed UB. D-Dimer and serum ferritin as an independ-ent risk factor for severity in COVID-19 patients. Mater Today Proc. 2021 Apr 13.
     [Google Scholar]
  23. Hwaiz R, Merza M, Hamad B, HamaSalih S, Mohammed M, Hama H. Evaluation of hepatic enzymes activities in COVID-19 patients. Int Immunopharmacol. 2021 97::107701.
     [Google Scholar]
  24. Ishaq SE, Abdulqadir SZ, Khudhur ZO, Omar SA, Qadir MK, Awla HK, et al. Comparative study of SARS-CoV-2 antibody titers between male and female COVID-19 patients living in Kurdistan region of Iraq. Gene Rep. 2021 Dec; 25::101409.
     [Google Scholar]
  25. Kaftan AN, Hussain MK, Algenabi AA, Naser FH, Enaya MA. Predictive value of C-reactive protein, lactate dehydrogenase, fer-ritin and D-dimer levels in diagnosing COVID-19 patients: a retrospective study. Acta Inform Med. 2021; 29:(1):45–50.
     [Google Scholar]
  26. Khalaf NS, Sultan HI, Hussein AL. Characteristics of 150 patients with COVID 19 infection in Samara General Hospital, Sala-haddin Governorate, Iraq. Eur J Mol Clin Med. 2020; 7:(9):1275–82.
     [Google Scholar]
  27. Khudair K, AL-Hadraawy MK. Study the relationship between CRP and Ferritin in people infection with COVID-19 in AL-Najaf Governorate, Iraq. Al-Kufa Univ J Biol. 2020; 12:(1):20–6.
     [Google Scholar]
  28. Mahmood, ZS, Fadhil, HY, Ad’hiah, AH. Estimation of hematological parameters of disease severity in Iraqi patients with COVID-19. Iraqi J Sci. 2021; 62:(10): 3487–96.
     [Google Scholar]
  29. Majeed KR, Al-Fahad D, Jalood HH, Hantosh HA, Ali MK, Sakthivel S, et al. RhD blood type significantly influences susceptibil-ity to contract COVID-19 among a study population in Iraq. F1000Research. 2021, 10::38.
     [Google Scholar]
  30. Merza MY, Hwaiz RA, Hamad BK, Mohammad KA, Hama HA, Karim AY. Analysis of cytokines in SARS-CoV-2 or COVID-19 pa-tients in Erbil city, Kurdistan region of Iraq. PLoS One. 2021; 16:(4):e0250330.
     [Google Scholar]
  31. Rostam SRK, Shekhany KAM, Smail, HO. Comparative study of some biochemical parameters among of COVID-19 symptoms and non COVID-19 symptoms individuals. BIOVALENTIA: Biol Res J. 2020; 6:(2).
     [Google Scholar]
  32. Sarhan AR, Hussein TA, Flaih MH, Hussein KR. A biochemical analysis of patients with COVID-19 infection. Biochem Res Int. 2021 Oct 22 2021::1383830.
     [Google Scholar]
  33. Shareef RH, Zwain ZD, Mahbuba WA. Superiority of lymphocyte ratio over total leukocyte count in detecting the severity of COVID-19 pneumonia. Heliyon. 2021 Nov; 7:(11):e08412.
     [Google Scholar]
  34. Al-Ani A. Reactive lymphocytes in blood film of a COVID-19 Iraqi patient: A case report. Infection. 2022; 20:(21):50.
     [Google Scholar]
  35. Masana L, Correig E, Ibarretxe D, Anoro E, Arroyo JA, Jericó C, et al. Low HDL and high triglycerides predict COVID-19 severity. Sci Rep. 2021 11::7217.
     [Google Scholar]
  36. Zhang ZL, Hou YL, Li DT, Li FZ. Laboratory findings of COVID-19: a systematic review and meta-analysis. Scand J Clin Lab Invest. 2020; 80:(6):441–7.
     [Google Scholar]
  37. Chen C, Zhang Y, Zhao X, Tao M, Yan W, Fu Y. Hypoalbuminemia – An indicator of the severity and prognosis of COVID-19 patients: a multicentre retrospective analysis. Infect Drug Resist. 2021 14::3699–710.
     [Google Scholar]
  38. Kermali M, Khalsa RK, Pillai K, Ismail Z, Harky A. The role of biomarkers in diagnosis of COVID-19 – A systematic review. Life Sci. 2020; 254::117788.
     [Google Scholar]
  39. Orhan S, Mecit BBT, Kazan ED, Kazan S, Konya PS, Gulsoy KY. The effect of acute phase reactants on the survival of COVID-19 patients in intensive care. Progr Nutr [Internet]. 2021 Sep 16; 23:(S2):e2021268.
     [Google Scholar]
  40. Zhang Y, Geng X, Tan Y, Li Q, Xu C, Xu J, et al. New understanding of the damage of SARS-CoV-2 infection outside the respir-atory system. Biomed Pharmacother. 2020 Jul; 127::110195.
     [Google Scholar]
  41. Kumar MP, Mishra S, Jha DK, Shukla J, Choudhury A, Mohindra R, et al. Coronavirus disease (COVID-19) and the liver: a com-prehensive systematic review and meta-analysis. Hepatol Int. 2020 Sep; 14:(5):711–22.
     [Google Scholar]
  42. Bzeizi K, Abdulla M, Mohammed N, Alqamish J, Jamshidi N, Broering D. Effect of COVID-19 on liver abnormalities: a system-atic review and meta-analysis. Sci Rep. 2021 May 19; 11:(1):10599.
     [Google Scholar]
  43. Medetalibeyoglu A, Catma Y, Senkal N, Ormeci A, Cavus B, Kose M, et al. The effect of liver test abnormalities on the prog-nosis of COVID-19. Ann Hepatol. 2020 Nov-Dec; 19:(6):614–21.
     [Google Scholar]
  44. Martha JW, Wibowo A, Pranata R. Prognostic value of elevated lactate dehydrogenase in patients with COVID-19: a system-atic review and meta-analysis. Postgrad Med J. 2021 Jan 15:postgradmedj-2020-139542.
     [Google Scholar]
  45. Liu X, Wang J, Xu X, Liao G, Chen Y, Hu CH. Patterns of IgG and IgM antibody response in COVID-19 patients. Emerg Mi-crobes Infect. 2020; 9:(1):1269–74.
     [Google Scholar]
  46. Chen M, Qin R, Jiang M, Yang Z, Wen W, Li J. Clinical applications of detecting IgG, IgM or IgA antibody for the diagnosis of COVID-19: A meta-analysis and systematic review. Int J Infect Dis. 2021 104::415–22.
     [Google Scholar]
  47. Leisman DE, Ronner L, Pinotti R, Taylor MD, Sinha P, Calfee CS, et al. Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes. Lancet Respir Med. 2020; 8:(12):1233–44.
     [Google Scholar]
  48. Mulchandani R, Lyngdoh T, Kakkar AK. Deciphering the COVID-19 cytokine storm: systematic review and meta-analysis. Eur J Clin Invest. 2021; 51:(1):e13429.
     [Google Scholar]
  49. Liu N, Zhang T, Ma L, Zhang H, Wang H, Wei W, et al. The impact of ABO blood group on COVID-19 infection risk and mortal-ity: a systematic review and meta-analysis. Blood Rev. 2021 48::100785.
     [Google Scholar]
  50. Kabrah SM, Kabrah AM, Flemban AF, Abuzerr S. Systematic review and meta-analysis of the susceptibility of ABO blood group to COVID-19 infection. Transfus Apher Sci. 2021; 60:(4):103169.
     [Google Scholar]
  51. Lee JJ, Montazerin SM, Jamil A, Jamil U, Marszalek J, Chuang ML, Chi G. Association between red blood cell distribution width and mortality and severity among patients with COVID-19: A systematic review and meta-analysis. J Med Virol. 2021 Apr; 93:(4):2513–22.
     [Google Scholar]
  52. Ramachandran P, Gajendran M, Perisetti A, Elkholy KO, Chakraborti A, Lippi G, Goyal H. Red blood cell distribution width in hospitalized COVID-19 patients. Front Med (Lausanne). 2022 Jan 7 8::582403.
     [Google Scholar]
  53. Huang I, Pranata R. Lymphopenia in severe coronavirus disease-2019 (COVID-19): systematic review and meta-analysis. J Intens Care. 2020 8::36.
     [Google Scholar]
  54. Moutchia J, Pokharel P, Kerri A, McGaw K, Uchai S, Nji M, Goodman M. Clinical laboratory parameters associated with se-vere or critical novel coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis. PLoS One. 2020 Oct 1; 15:(10):e0239802.
     [Google Scholar]
  55. Alsharif W, Qurashi A. Effectiveness of COVID-19 diagnosis and management tools: a review. Radiography (Lond). 2021 May; 27:(2):682–7. doi: 10.1016/j.radi.2020.09.010.
     [Google Scholar]
  56. Kovács A, Palásti P, Veréb D, et al. The sensitivity and specificity of chest CT in the diagnosis of COVID-19. Eur Radiol. 2021 31::2819–24.
     [Google Scholar]
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Assessment of diagnostic procedures and tools of COVID-19 among Iraqi patients: A systematic review
Journal of Emergency Medicine, Trauma and Acute Care 2022, 5 (2022); https://doi.org/10.5339/jemtac.2022.aimco.5
/content/journals/10.5339/jemtac.2022.aimco.5
/content/journals/10.5339/jemtac.2022.aimco.5
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Keyword(s): biochemical parameters, COVID-19, diagnostic procedures, hematological parameters, immunological parameters, Iraq and systematic review

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