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6 The Anbar 2nd International Medical Conference (AIMCO 2022)
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

The aim of this paper was to assess the prevalence and association between infection and alcohol, or cigarette use among Iraqi patients.

115 individuals needed upper gastrointestinal endoscopies in total. Reverse transcription polymerase chain reaction (RT-PCR), urea breath test, rapid urease test, CagA-IgG, and culture were all used to confirm infection. The information on alcohol consumption, smoking, sex, and age was collected using a standard questionnaire.

The gold standard test, RT-PCR, was used to detect infection in 81 (70.4%) of patients. infection was not affected by age (OR: 0.976; CI: 95% (0.944-1.009; P > 0.05), sex (OR: 1.26, 95% CI: 0.57–2.75; P > 0.05), or alcohol intake (OR: 0.293; CI: 95% (0.081-1.058; P > 0.05) according to the binary logistic regression analysis. Additionally, there was a considerable inverse association between smoking and infection (OR: 0.094; CI: 95% (0.025-0.352; P < 0.05). According to binary logistic regression analysis, both smoking (OR: 0.036; CI: 95% (0.007-0.182; P < 0.05) and alcohol intake (OR: 0.179; CI: 95% (0.041-0.988; P < 0.05) were inversely and significantly related with illness whereas infection did not alter with age (OR: 1.001; CI 95% (0.959-1.044; P > 0.05) in the male subgroup.

According to the study, males who smoke and drink are more likely to have infections. Furthermore, there was no positive association between age and infection.

© 2022 Hussein, Al-Ouqaili, Majeed, licensee HBKU Press.
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2022-12-06
2024-04-26
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References

  1. Agudo S, Pérez-Pérez G, Alarcón T, López-Brea M. High prevalence of clar-ithromycin-resistant Helicobacter pylori strains and risk factors associated with resistance in Madrid, Spain. J Clin Micro-biol.2010 Oct; 48:(10):3703-7.
     [Google Scholar]
  2. Wu W, Leja M, Tsukanov V, Basharat Z, Hua D, Hong W. Sex differences in the relationship among alcohol, smok-ing, and Helicobacter pylori infection in asymptomatic individuals. J Int Med Res. 2020 May; 48:(5):0300060520926036.
     [Google Scholar]
  3. AL-Ouqaili MT, Abdullah EM. Detection of 16S r RNA gene of Helicobacter pylori in patients with peptic ulcer and gastric carcinoma: molecular and bacteriological study. Egypt. Acad. J. Biolog. Sci. (G-Microbiology). 2011 Dec;1 3:(1):95-104.
     [Google Scholar]
  4. Nagy P, Johansson S, Molloy-Bland M. Systematic review of time trends in the prevalence of Helicobacter pylori infection in China and the USA. Gut pathog. 2016 Dec; 8:(1):1-4.
     [Google Scholar]
  5. Zhang L, Eslick GD, Xia HH, Wu C, Phung N, Talley NJ. Relationship between alcohol consumption and active Helicobacter pylori infection. Alcohol & Alcohol Alcohol. 2010 Jan;1 45:(1):89-94.
     [Google Scholar]
  6. Murray LJ, Lane AJ, Harvey IM, Donovan JL, Nair P, Harvey RF. Inverse relationship between alcohol consumption and active Helicobacter pylori infection: the Bristol Helicobacter project. Am J Gastroenterol. 2002 Nov;1 97:(11):2750-5.
     [Google Scholar]
  7. Hussein RA, Al-Ouqaili MT, Majeed YH. Detection of Helicobacter Pylori infection by invasive and non-invasive techniques in patients with gastrointestinal diseases from Iraq: A validation study. Plos one. 2021 Aug23; 16:(8):e0256393.
     [Google Scholar]
  8. Cheng KH, Chu CS, Lin TH, Lee KT, Sheu SH, Lai WT. Lipid paradox in acute myocardial infarction—the association with 30-day in-hospital mortality. Crit Care Med. 2015 Jun;1 43:(6):1255-64.
     [Google Scholar]
  9. Al-Ouqaili, MTS, Jal’oot AS, Badawy AS. Identification of an OprD and blaIMP gene-mediated car-bapenem resistance in Acinetobacter baumannii and Pseudomonas aeruginosa among patients with wound infections in Iraq. Asian Journal of Pharmaceutics (AJP). 2018 Nov5; 12:(03).
     [Google Scholar]
  10. Hussein RA, Al-Ouqaili MT, Majeed YH. Detection of clarithromycin resistance and 23SrRNA point mutations in clinical isolates of Helicobacter pylori isolates: Phenotypic and molecular methods. Saudi J Biol Sci. 2022 Jan;1 29:(1):513-20.
     [Google Scholar]
  11. Shi R, Xu S, Zhang H, Ding Y, Sun G, Huang X, Chen X, Li X, Yan Z, Zhang G. Prevalence and risk factors for Helicobacter pylori infection in Chinese populations. Helicobacter. 2008 Apr; 13:(2):157-65.
     [Google Scholar]
  12. Eusebi LH, Zagari RM, Bazzoli F. Epidemiology of Helicobacter pylori infection. Helicobacter. 2014 Sep;19 Suppl 1::1-5.
     [Google Scholar]
  13. Hong W, Tang H, Dong X, Hu SK, Yan Y, Basharat Z, Zimmer V, Tzivian10 L, Leja11 M, Gao12 ZH, Sharma13 A. Prevalence of Helicobacter pylori infection in a third-tier Chinese city: relationship with gender, age, birth-year and survey years. Microb Health Dis. 2019; 1::e150.
     [Google Scholar]
  14. Zhu Y, Zhou X, Wu J, Su J, Zhang G. Risk factors and prevalence of Helicobacter pylori infection in persistent high incidence area of gastric carcinoma in Yangzhong city. Gastroenterol Res Pract. 2014 Oct;2014.
     [Google Scholar]
  15. Lee JH, Choi KD, Jung HY, Baik GH, Park JK, Kim SS, et al. Korean College of Helicobacter and Upper Gastroin-testinal Research. Seroprevalence of Helicobacter pylori in Korea: a multicenter, nationwide study conducted in 2015 and 2016. Helicobacter. 2018; 23::e12463.
     [Google Scholar]
  16. Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of Helicobacter pylori in Turkey: a national-ly-representative, cross-sectional, screening with the 13C-Urea breath test. BMC public health. 2013 Dec; 13:(1):1-2.
     [Google Scholar]
  17. Ashtari S, Pourhoseingholi MA, Molaei M, Taslimi H, Zali MR. The prevalence of Helicobacter pylori is decreasing in Iranian patients. Gastroenterol Hepatol Bed Bench. 2015; 8:(Suppl1):S23.
     [Google Scholar]
  18. Ogihara A, Kikuchi S, Hasegawa A, Kurosawa M, Miki K, Kaneko E, et al. Relationship between Helicobacter pylori infection and smoking and drinking habits. J Gastroenterol Hepatol. 2000 Mar;10 15:(3):271-6.
     [Google Scholar]
  19. Sánchez-Cuén JA, Irineo Cabrales AB, Bernal Magaña G, Peraza Garay FJ. Helico-bacter pylori infection and its association with alcohol consumption: a case-control study. Rev Gastroenterol Mex. 2013 Jul;1 78:(3):144-50.
     [Google Scholar]
  20. Jia Y, Qu B, Wang Z, Han X, Ren G. Effects of active and latent H. pylori infection coupled with chronic alcohol ingestion on cytokine profiles and markers of oxidative balance in men seropositive for H. pylori CagA Ab: An observa-tional study. Medicine. 2018 Aug; 97:(34).
     [Google Scholar]
  21. Rosenstock SJ, Jørgensen T, Andersen LP, Bonnevie O. Association of Helicobacter pylori infection with lifestyle, chronic disease, body-indices, and age at menarche in Danish adults. Scand J Public Health. 2000 Jan; 28:(1):32-40.
     [Google Scholar]
  22. Moayyedi P, Axon AT, Feltbower R, Duffett S, Crocombe W, Braunholtz D, Richards IG, et al. Relation of adult life-style and socioeconomic factors to the prevalence of Helicobacter pylori infection. Int J Epidemiol. 2002 Jun;1 31:(3):624-31.
     [Google Scholar]
  23. Bujanda L. The effects of alcohol consumption upon the gastrointestinal tract. Am J Gastroenterol. 2000 Dec;1 95:(12):3374-82.
     [Google Scholar]
  24. Lieber CS. Gastric Ethanol Metabolism and Gastritis: Interactions with Other Drugs, Helicobacter pylori, and Anti-biotic Therapy (1957-1997)—a Review. Alcohol Clin Exp Res. 1997 Nov; 21:(8): 1360-6.
     [Google Scholar]
  25. Federico A, Cotticelli G, Festi D, Schiumerini R, Addolorato G, Ferrulli A, et al. The effects of alcohol on gastroin-testinal tract, liver and pancreas: evidence-based suggestions for clinical management. Eur Rev Med Pharmacol Sci. 2015 May; 19:(10):1922-40.
     [Google Scholar]
  26. Qin X, Deitch EA. Dissolution of lipids from mucus: A possible mechanism for prompt disruption of gut barrier function by alcohol. Toxicol Lett. 2015 Jan;22 232:(2):356-62.
     [Google Scholar]
  27. Rakshitha Hb, Amita K, Gouri M, Balekuduru A. Relation of alcohol to Helicobacter pylori infection: A cross sec-tional study. IP J Diagn Pathol Oncol. 2018; 3:(3):145-149.
     [Google Scholar]
  28. Kao CY, Sheu BS, Wu JJ. Helicobacter pylori infection: An overview of bacterial virulence factors and pathogene-sis. Biomed J. 2016 Feb;1 39:(1):14-23.
     [Google Scholar]
  29. Hage N, Howard T, Phillips C, Brassington C, Overman R, Debreczeni J, et al. Structural basis of Lewisb antigen binding by the Helicobacter pylori adhesin BabA. Sci Adv. 2015 Aug 14; 1:(7):e1500315.
     [Google Scholar]
  30. Yamaoka Y, Kikuchi S, El–Zimaity HM, Gutierrez O, Osato MS, Graham DY. Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production. Gastroenterology. 2002 Aug;1 123:(2):414-24.
     [Google Scholar]
  31. Khalifa MAAA, Khodiar SE, Abd Almaksoud A. Cigarette smoking status and Helicobacter pylori infection in non-ulcer dyspepsia patients. Egypt J Chest Dis Tuberc. 2014 Jul;1 63:(3):695-9.
     [Google Scholar]
  32. Woodward M, Morrison C, McColl K. An investigation into factors associated with Helicobacter pylori infection. J Clin Epidemiol. 2000 Feb; 53:(2):175-81.
     [Google Scholar]
  33. Endoh K, Leung FW. Effects of smoking and nicotine on the gastric mucosa: a review of clinical and experimental evidence. Gastroenterology. 1994 Sep; 107:(3):864-78.
     [Google Scholar]
  34. Andersen IB, Jørgensen T, Bonnevie O, Grønbaek M, Sørensen TI. Smoking and al-cohol intake as risk factors for bleeding and perforated peptic ulcers: a population-based cohort study. Epidemiology. 2000 Jul; 11:(4):434-9.
     [Google Scholar]
  35. Parasher G, Eastwood GL. Smoking and peptic ulcer in the Helicobacter pylori era. Eur J Gastroenterol Hepatol. 2000 Aug; 12:(8):843-53.
     [Google Scholar]
  36. Li LF, Chan RL, Lu L, Shen J, Zhang L, Wu WK, et al. Cigarette smoking and gastrointestinal diseases: the causal relationship and underlying molecular mechanisms. Int J Mol Med. 2014 Aug 1; 34:(2):372-80.
     [Google Scholar]
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Association between alcohol consumption, cigarette smoking, and Helicobacter pylori infection in Iraqi patients submitted to gastrointestinal endoscopy
Journal of Emergency Medicine, Trauma and Acute Care 2022, 12 (2022); https://doi.org/10.5339/jemtac.2022.aimco.12
/content/journals/10.5339/jemtac.2022.aimco.12
/content/journals/10.5339/jemtac.2022.aimco.12
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Keyword(s): Alcohol, H. pylori, PCR and Smoking

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