1887
Volume 2025, Issue 3
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Osteoarticular infections (OAIs) in Qatar’s pediatric population represent a significant source of morbidity, highlighting the need for a comprehensive evaluation of their clinical, microbiological, and treatment characteristics. Understanding the presentation and management of these infections is essential for optimizing patient outcomes and guiding future therapeutic approaches.

Retrospective cohort study of 62 hospitalized children with OAIs treated at Hamad Medical Corporation from 2016 to 2018.

Over 2 years, 62 patients were diagnosed and treated for OAIs. Osteomyelitis emerged as the most prevalent infection type, comprising 48.4% of cases, followed by septic arthritis at 20.9% and concurrent infections at 17.7%. The cohort demonstrated a male predominance of 66.1%. The common clinical manifestations included fever (77.4%), functional limitations (82.3%), and pain (88.7%). was the most frequently isolated pathogen, present in 24.1% (15/62) of cases, with approximately 50% of these being methicillin-resistant . Among the radiological studies conducted, 75% revealed abnormal ultrasound findings, while all patients exhibited abnormal magnetic resonance imaging results ( = 53). The antibiotic regimen most frequently prescribed was clindamycin (79%), followed by the cephalosporin ceftriaxone (67.7%). The group with concurrent infections showed the longest duration of both parenteral and oral antibiotic therapy, the highest complication rates, and the longest median hospital stay of 21 days.

OAIs present substantial clinical challenges, marked by complex presentations and diagnostic difficulties. remains the predominant pathogen, with methicillin-resistant accounting for nearly half of the cases. Concurrent infections are linked with more severe complications and prolonged hospitalizations, though they also exhibit the highest rates of positive microbiological results.

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References

  1. Momodu II, Savaliya V. Septic arthritis. [Updated 2022 Jul 4]. In: StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; 2023. https://www.ncbi.nlm.nih.gov/books/NBK538176/
    [Google الباحث العلمي]
  2. Le Saux N. Diagnosis and management of acute osteoarticular infections in children. Paediatr Child Health. 2018 Aug;23:(5):336–43. https://doi.org/10.1093/pch/pxy049
    [Google الباحث العلمي]
  3. Dartnell J, Ramachandran M, Katchburian, M. Haematogenous acute and subacute paediatric osteomyelitis: a systematic review of the literature. J Bone Joint Surg Br. 2012;94:584-95. https://doi.org/10.1302/0301-620X.94B5.28523
    [Google الباحث العلمي]
  4. Krogstad P Septic arthritis. In: Cherry JD, Harrison G, Kaplan SL, Steinbach W, Hotez PJ. (eds.) Feigin and Cherry's Textbook of Pediatric Infectious Diseases. 8th ed. Philadelphia, PA: Elsevier; 2018.p.529.
    [Google الباحث العلمي]
  5. Yagupsky P, Bar-Ziv Y, Howard CB, Dagan R. Epidemiology, etiology, and clinical features of septic arthritis in children younger than 24 months. Arch Pediatr Adolesc Med. 1995 May;149:(5):537–40. https://doi.org/10.1001/archpedi.1995.02170180067010
    [Google الباحث العلمي]
  6. Woods CR, Bradley JS, Chatterjee A, Copley LA, Robinson J, Kronman MP, et al. Clinical practice guideline by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America: 2021 guideline on Diagnosis and Management of Acute Hematogenous Osteomyelitis in Pediatrics. J Pediatric Infect Dis Soc. 2021 Aug;10:(8):801-44. https://doi.org/10.1093/jpids/piab027
    [Google الباحث العلمي]
  7. Blyth MJ, Kincaid R, Craigen MA, Bennet GC. The changing epidemiology of acute and subacute haematogenous osteomyelitis in children. J Bone Joint Surg Br. 2001 Jan;83:(1):99–102. https://doi.org/10.1302/0301-620x.83b1.10699
    [Google الباحث العلمي]
  8. Arnold SR, Elias D, Buckingham SC, Thomas ED, Novais E, Arkader A, et al. Changing patterns of acute hematogenous osteomyelitis and septic arthritis: emergence of community-associated methicillin-resistant Staphylococcus aureus. J Pediatr Orthop. 2006 Nov-Dec;26:(6):703-8. https://doi.org/10.1097/01.bpo.0000242431.91489.b4
    [Google الباحث العلمي]
  9. Iliadis AD, Ramachandran M. Paediatric bone and joint infection. EFORT Open Rev. 2017;2:7-12. https://doi.org/10.1302/2058-5241.2460027
    [Google الباحث العلمي]
  10. Ilharreborde, B. Sequelae of pediatric osteoarticular infection. Orthop Traumatol Surg Res. 2015 Feb;101:S129-37. https://doi.org/10.1016/j.otsr.2014.07.029
    [Google الباحث العلمي]
  11. Howard-Jones AR, Isaacs D. Systematic review of duration and choice of systemic antibiotic therapy for acute haematogenous bacterial osteomyelitis in children. J Paediatr Child Health. 2013 Sep;49:(9):760–8. https://doi.org/10.1111/jpc.12251
    [Google الباحث العلمي]
  12. Campion EW, Peltola H, Paakkonen M. Acute osteomyelitis in children. N Engl J Med. 2014;370:(4):352-60. https://doi.org/10.1056/NEJMra1213956
    [Google الباحث العلمي]
  13. Stockmann C, Ampofo K, Pavia AT, Byington CL, Baschke AJ, Sherwin CM, et al. National trends in the incidence, outcomes and charges of pediatric osteoarticular infections, 1997-2012. Pediatr Infect Dis J. 2015 Jun;34:(6):672–4. https://doi.org/10.1097/INF.0000000000000686
    [Google الباحث العلمي]
  14. Arnold SR, Elias D, Buckingham SC, Thomas ED, Novais E, Arkader A, et al. Changing patterns of acute hematogenous osteomyelitis and septic arthritis: emergence of community-associated methicillin-resistant Staphylococcus aureus. J Pediatr Orthop. 2006 Nov-Dec;26:(6):703-8. https://doi.org/10.1097/01.bpo.0000242431.91489.b4
    [Google الباحث العلمي]
  15. Martinez-Aguilar G, Avalos-Mishaan A, Hulten K, Hammerman W, Mason EO Jr, Kaplan SL. Community-acquired, methicillin resistant and methicillin-susceptible Staphylococcus aureus musculoskeletal infections in children. Pediatr Infect Dis J. 2004 Aug;23:(8):701–6. https://doi.org/10.1097/01.inf.0000133044.79130.2a
    [Google الباحث العلمي]
  16. Jaramillo D, Dormans JP, Delgado J, Laor, T. St Geme JW. Hematogenous osteomyelitis in infants and children: imaging of a changing disease. Radiology. 2017 Jun; 283:(3):629-43. https://doi.org/10.1148/radiol.2017151929
    [Google الباحث العلمي]
  17. Musso P, Parigi S, Bossi G, Marseglia GL, Galli L, Chiappini E. Epidemiology and management of acute hematogenous osteomyelitis, neonatal osteomyelitis and spondylodiscitis in a third level paediatric center. Children (Basel). 2021 Jul;8:(8):616. https://doi.org/10.3390/children8080616
    [Google الباحث العلمي]
  18. Calvo C, Nunez E, Camacho M, Clemente D, Fernandez-Cooke E, Alcobendas R,et al. Epidemiology and management of acute, uncomplicated septic arthritis and osteomyelitis: Spanish multicenter study. Pediatr Infect Dis J. 2016 Dec;35:(12):1288–93. https://doi.org/10.1097/INF.0000000000001309
    [Google الباحث العلمي]
  19. Whitney CG, Pilishvili T, Farley MM, Schaffner W, Craig A, Lynfield R, et al. Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study. Lancet. 2006 Oct; 368:(9546):1495-502. https://doi.org/10.1016/S0140-6736(06)69637-2
    [Google الباحث العلمي]
  20. Nuorti JP, Whitney CG; Centers for Disease Control and Prevention (CDC). Prevention of pneumococcal disease among infants and children - use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine - recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2010 Dec;59:(RR11):1-8.
    [Google الباحث العلمي]
  21. Moore MR, Link-Gelles R, Schaffner W, Lynfield R, Lexau C, Bennett N, et al. Effect of use of 13-valent pneumococcal conjugate vaccine in children on invasive pneumococcal disease in children and adults in the USA: analysis of multisite, population-based surveillance. Lancet Infect Dis. 2015 Mar;15:(3):301–9. https://doi.org/10.1016/S1473-3099(14)71081-3
    [Google الباحث العلمي]
  22. Olarte L, Romero J, Barson W, Bradley J, Lin PL, Givner L, et al. Osteoarticular infections caused by Streptococcus pneumoniae in children in the post-pneumococcal conjugate vaccine era. Pediatr Infect Dis J. 2017 Dec;36:(12):1201–4. https://doi.org/10.1097/INF.0000000000001697
    [Google الباحث العلمي]
  23. Principi N, Esposito S. Kingella kingae infections in children. BMC Infect Dis. 2015 Jul;15:260. https://doi.org/10.1186/s12879-015-0986-9
    [Google الباحث العلمي]
  24. Chometon S, Benito Y, Chaker M, Boisset S, Ploton C, Berard J, et al. Specific real-time polymerase chain reaction places Kingella kingae as the most common cause of osteoarticular infections in young children. Pediatr Infect Dis J. 2007 May;26:(5):377–81. https://doi.org/10.1097/01.inf.0000259954.88139.f4
    [Google الباحث العلمي]
  25. Alhammadi A, Janahi M, Khalifa M, Alnuaimi L, Alqadi M, Sami M. PO-0215. Epidemiology of acute osteomyelitis in children: a retrospective study from Qatar. Arch Dis Childhood. 2014;99:A315-6. http://dx.doi.org/10.1136/archdischild-2014-307384.870
    [Google الباحث العلمي]
  26. Yi J, Wood JB, Creech CB, Williams D, Jimenez-Truque N, Yildirim I, et al. Clinical epidemiology and outcomes of pediatric musculoskeletal infections. J Pediatr. 2021 Jul;234:236-44.e2. https://doi.org/10.1016/j.jpeds.2021.03.028
    [Google الباحث العلمي]
  27. Al Zamil FA, Al Saadi MM, Bokhary NA, Al Shamsa L, Al Alola S, Al Eissa Y. The clinical profile of childhood osteomyelitis: a Saudi experience. J Pediatr Infect Dis. 2015 Jul; 3:235-40. https://doi.org/10.1055/s-0035-1556996
    [Google الباحث العلمي]
  28. Montgomery CO, Siegel E, Blasier RD, Suva LJ. Concurrent septic arthritis and osteomyelitis in children. J Pediatr Orthop. 2013 Jun;33:(4):464-7. https://doi.org/10.1097/BPO.0b013e318278484f
    [Google الباحث العلمي]
  29. Trobisch A, Schweintzger NA, Kohlfürst DS, Sagmeister MG, Sperl M, Grisold AJ, et al.; the EUCLIDS consortium. Osteoarticular infections in pediatric hospitals in Europe: a prospective cohort study from the EUCLIDS Consortium. Front Pediatr. 2022 May;10:744182. https://doi.org/10.3389/fped.2022.744182
    [Google الباحث العلمي]
  30. Bonhoeffer J, Haeberle B, Schaad UB, Heininger U. Diagnosis of acute haematogenous osteomyelitis and septic arthritis: 20 years experience at the University Children's Hospital Basel. Swiss Med Wkly. 2001 Oct 6;131:(39-40):575-81.
    [Google الباحث العلمي]
  31. Carrillo-Marquez MA, Hulten KG, Hammerman W, Mason EO, Kaplan SL. USA300 is the predominant genotype causing Staphylococcus aureus septic arthritis in children. Pediatr Infect Dis J. 2009 Dec;28:(12):1076–80. https://doi.org/10.1097/INF.0b013e3181adbcfe
    [Google الباحث العلمي]
  32. Yagupsky P. Kingella kingae: from medical rarity to an emerging paediatric pathogen. Lancet Infect Dis. 2004 Jun;4:(6):358–67. https://doi.org/10.1016/S1473-3099(04)01046-1
    [Google الباحث العلمي]
  33. Principi N, Esposito S. Kingella kingae infections in children. BMC Infect Dis. 2015 Jul;15:260. https://doi.org/10.1186/s12879-015-0986-9
    [Google الباحث العلمي]
  34. Saavedra-Lozano J, Falup-Pecurariu O, Faust SN, Girschick H, Hartwig N, Kaplan S, et al. Bone and joint infections. Pediatr Infect Dis J. 2017 Aug;36:(8):788–99. https://doi.org/10.1097/INF.0000000000001635
    [Google الباحث العلمي]
  35. Alvares PA, Mimica MJ. Osteoarticular infections in pediatrics. J Pediatr (Rio J). 2020 Mar-Apr;96 Suppl 1:(Suppl 1):58-64. https://doi.org/10.1016/j.jped.2019.10.005
    [Google الباحث العلمي]
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  • نوع المستند: Research Article
الموضوعات الرئيسية Osteoarticular, osteomyelitis, pediatrics, septic arthritis, State of Qatar

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