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A new mechanistic and spatially-explicit model of hydrological and entomological processes that lead to malaria transmission has been developed recently at MIT. This unique model was tested against field observations from Africa. HYDREMATS (Hydrology, Entomology, and Malaria Transmission Simulator) is described in (Bomblies, Duchemin, and Eltahir, WRR, 44, 2008). HYDREMATS is suitable for low cost screening of environmental management interventions, and for studying the impact of climate change on malaria transmission. Examples of specific applications will be presented for two villages from Niger in Africa.