1887

Abstract

Abstract

The aim of this study was to find the relationship between the Organochlorine and PCBs pesticides residues and female breast cancer, together with the related genetic polymorphisms, biochemical parameters and anthropometric measurements in Sudanese female breast cancer patients attending the Wad-Madina teaching hospital, Gezira State, Sudan. The prospective study was performed on 200 female breast cancer patients (of ages ranging between 25-80 years). 100 healthy persons of a range of ages and from different community areas were chosen to form a control group. The Organochlorine and PCBs pesticides residues were measured in serum and adipose tissues. We used Gas chromatographs, Thermoquest-Trace GC with 63Ni selective Electron- Capture Detector with advanced software and Nucon-GC-5765 series equipped with Nitrogen Phosphorus Detector. The genetic polymorphisms was determined the Cytochrome P- 450 (CYP1A1) in the blood and tissues. The DNA extraction by QIAamp DNA Mini Kits .PCR Technique was used for laboratory genetic analysis by using Genotypes Restriction Enzymes Length Polymorphisms (RFLP). Anthropometrics measurements were determined by weight, height and body mass index (BMI). A questionnaire was completed in order to obtain information regarding: sociodemographic characteristics, obstetric and gynaecological variables and nutritional information. The risk of breast cancer increased among women with higher serum concentrations of any Organochlorine: o, p’-DDT, p, p’-DDT, p, p’-dichlorodiphenyldichloroethylene, hexachlorobenzene, beta-hexachlorocyclohexane, trans-nonachlor, cis-nonachlor, oxychlordane, mirex, or PCBs. The high serum levels of PCBs were associated with a decreased risk of breast cancer; CYP1A1 polymorphisms were more frequent in younger patients and in patients with high level Organochlorine pesticides. Organochlorine pesticide residues may increase the risk of breast cancer in females, particularly in premenopausal women in Sudan. CYP1A1 polymorphisms probably predispose to an earlier onset of breast cancer and might be associated with a higher Organochlorine pesticides level, but further studies on a much larger group are required to substantiate our findings.

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/content/papers/10.5339/qproc.2012.mutagens.3.37
2012-03-01
2019-09-17
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http://instance.metastore.ingenta.com/content/papers/10.5339/qproc.2012.mutagens.3.37
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  • Received: 09 May 2012
  • Accepted: 09 May 2012
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