1887

Abstract

Abstract

Perfusion-decellularized native lungs seeded with human BJ

RNA-induced pluripotent stem (BJ-RiPS) and umbilical vein endothelial cells failed to regenerate functional lung tissue as quantified by immunohistochemistry (no detection of TTF1,CC10,and Pro-SPB), gene expression (non-significant differences in lung-specific gene expression as compared to cells cultured under standard conditions), and in vitro lung gas exchange properties. Histological analysis of orthotopically transplanted BJ-RiPS lungs revealed a teratoma (detection of ectoderm: TuJ1, mesoderm: SMA, and endoderm: TTF1).

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/content/papers/10.5339/qfarf.2011.BMPS5
2011-11-20
2019-11-15
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