1887
Volume 2015, Issue 2
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

The exacerbation of chronic obstructive pulmonary disease (COPD) is a major factor for the high mortality associated with the disease. There is a paucity in the lung-specific biomarkers which diagnose these exacerbations. Surfactant protein D (SP-D) is a promising biomarker in predicting clinical outcomes for patients with COPD, is lung-specific and can be detected in serum. However, the profile in which serum concentrations of SP-D change during acute exacerbation is still unclear. This study aims to estimate and compare the concentrations of serum SP-D in patients with stable disease and during the exacerbation. A cross-sectional study was conducted which composed of apparently healthy individuals (n = 28), which included 14 smokers and 14 nonsmokers, patients with stable COPD (n = 28), and patients experiencing acute exacerbations (n = 28). Pulmonary functions were performed for all groups. Serum SP-D concentrations were measured using enzyme-linked immunosorbent assay (ELISA). These concentrations were compared by analysis of variance. Serum SP-D levels were significantly elevated in patients with acute exacerbations (508.733 ± 102.813 ng/ml) compared to patients with stable COPD (337.916 ± 86.265 ng/ml) and healthy subjects (177.313 ± 46.998 ng/ml; p <  0.001). Serum SP-D levels correlated inversely with lung function parameters including FEV1%pred, FVC%pred and FEV1/FVC. Serum SP-D levels are raised early on during acute exacerbations of COPD, which could be a potential early diagnostic biomarker for COPD exacerbations.

Loading

Article metrics loading...

/content/journals/10.5339/qmj.2015.18
2016-01-26
2020-09-23
Loading full text...

Full text loading...

/deliver/fulltext/qmj/2015/2/qmj.2015.18.html?itemId=/content/journals/10.5339/qmj.2015.18&mimeType=html&fmt=ahah

References

  1. Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J. 2009; 33:5:11651185.
    [Google Scholar]
  2. Wei L, Xu D, Qian Y, Huang G, Ma W, Liu F, Shen Y, Wang Z, Li L, Zhang S, Chen Y. Comprehensive analysis of gene-expression profile in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2015; 10::11031109.
    [Google Scholar]
  3. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease updated 2015. Available at: www.goldcopd.com .
  4. Bahadori K, FitzGerald JM. Risk factors of hospitalization and readmission of patients with COPD exacerbation - systematic review. Int J Chron Obstruct Pulmon Dis. 2007; 2:3:241251.
    [Google Scholar]
  5. Thomsen M, Ingebrigtsen TS, Marott JL, Dahl M, Lange P, Vestbo J, Nordestgaard BG. Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease. JAMA. 2013; 309:22:23532361.
    [Google Scholar]
  6. Dickens JA, Miller BE, Edwards LD, Silverman EK, Lomas DA, Tal-Singer R, Evaluation of COPD Longitudinally to Identify Surrogate Endpoints (ECLIPSE) study investigators . COPD association and repeatability of blood biomarkers in the ECLIPSE cohort. Respir Res. 2011; 12::146155.
    [Google Scholar]
  7. Mannino DM, Biomarkers in COPD: The Search Continues! Eur Respir J. 2015; 45:4:872874.
    [Google Scholar]
  8. Sin DD, Leung R, Gan WQ, Man SP. Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: A pilot study. BMC Pulm Med. 2007; 7::13.
    [Google Scholar]
  9. Bowler RP. Surfactant protein D as a biomarker for chronic obstructive pulmonary disease. COPD. 2012; 9:6:651653.
    [Google Scholar]
  10. Moreno D, Garcia A, Lema D, De Sanctis JB. Surfactant protein D in chornic obstructive pulmonary disease (COPD). Recent Pat Endocr Metab Immune Drug Discov. 2014; 8:1:4247.
    [Google Scholar]
  11. Sin DD, Pahlavan PS, Man SF. Surfactant protein D: A lung specific biomarker in COPD? Ther Adv Respir Dis. 2008; 2:2:6574.
    [Google Scholar]
  12. Winkler C, Atochina-Vasserman EN, Holz O, Beers MF, Erpenbeck VJ, Krug N, Roepcke S, Lauer G, Elmlinger M, Hohlfeld JM. Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD. Respir Res. 2011; 12:1:2939.
    [Google Scholar]
  13. Barrow AD, Palarasah Y, Bugatti M, Holehouse AS, Byers DE, Holtzman MJ, Vermi W, Skjødt K, Crouch E, Colonna M. OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes. J Immunol. 2015; 194:7:33173326.
    [Google Scholar]
  14. Sorensen GL, Hoegh SV, Leth-Larsen R, Thomsen TH, Floridon C, Smith K, Kejling K, Tornoe I, Crouch EC, Holmskov U. Multimeric and trimeric subunit SP-D are interconvertible structures with distinct ligand interaction. Mol Immunol. 2009; 46:15:30603069.
    [Google Scholar]
  15. Ju CR, Liu W, Chen RC. Serum surfactant protein D: Biomarker of chronic obstructive pulmonary disease. Dis Markers. 2012; 32:5:281287.
    [Google Scholar]
  16. Jaw JE, Sin DD. Unifying thoracic biomarkers: Surfactant protein-D and beyond. Expert Rev Respir Med. 2012; 6:2:147154.
    [Google Scholar]
  17. Lock-Johansson S, Vestbo J, Sorensen G. Surfactant protein D, club cell protein 16, pulmonary and activation-regulated chemokine, C-reactive protein, and Fibrinogen biomarker variation in chronic obstructive lung disease. Respir Res. 2014; 15:1:147156.
    [Google Scholar]
  18. Calverley PMA, Georgopoulos D. Chronic obstructive pulmonary disease: Symptoms and signs. In: Postmas S, Siafakas NM, eds. Management of chronic obstructive pulmonary disease. Eur Respir Mon. 1998; 8::624.
    [Google Scholar]
  19. Sutherland ER, Cherniack RM. Management of chronic obstructive pulmonary disease. N Engl J Med. 2004; 350::26892697.
    [Google Scholar]
  20. Shakoori TA, Sin DD, Ghafoor F, Bashir S, Bokhari SN. Serum surfactant protein D during acute exacerbations of chronic obstructive pulmonary disease. Dis Markers. 2009; 27:6:287294.
    [Google Scholar]
  21. Lomas DA, Silverman EK, Edwards LD, Locantore NW, Miller BE, Horstman DH, Tal-Singer R, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints study investigators . Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD. Eur Respir J. 2009; 34:1:95102.
    [Google Scholar]
  22. Dahl M. Biomarkers for chronic obstructive pulmonary disease: Surfactant protein D and C-reactive protein. Am J Respir Crit Care Med. 2008; 177:11:11771178.
    [Google Scholar]
  23. Sorensen GL, Husby S, Holmskov U. Surfactant protein A and surfactant protein D variation in pulmonary disease. Immunobiology. 2007; 212:4–5:381416.
    [Google Scholar]
  24. El-Deek SE, Makhlouf HA, Saleem TH, Mandour MA, Mohamed NA. Surfactant protein D, soluble intercellular adhesion molecule-1 and high-sensitivity C-reactive protein as biomarkers of chronic obstructive pulmonary disease. Med Princ Pract. 2013; 22:5:469474.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5339/qmj.2015.18
Loading
/content/journals/10.5339/qmj.2015.18
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error