1887
Volume 2011, Issue 2
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

In our study we present two cases that have been diagnosed as stage I endometrial carcinoma where a Levonorgestrel intrauterine releasing system (LNG-IUS) referred to as Mirena was used as a primary treatment because the standard surgical treatment was deemed to carry an unacceptable risk of death. Histopathology report after therapy showed complete regression of endometrial cancer.

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/content/journals/10.5339/qmj.2011.2.17
2011-12-01
2019-10-18
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References

  1. [1].   Levonorgestrel intro-uterine system for menorrhagio. . Drug Ther Bull . 2001; ;39: : 85– 87 .
    [Google Scholar]
  2. [2]. Abu   J., , Brown   L., , Ireland   D. . Endometrial adenocarcinoma following insertion of the levonorgestrel - Releasing intra-uterine system (Mirena) in a 36 year old woman. . Inter J Gyn Cancer . 2006; ;16: : 1439– 1478 .
    [Google Scholar]
  3. [3]. Theodoros   G., , Simon   BM., , Anil   T. . Levonorgestrel releasing intrauterine system (LNG-IUS) as a therapy for endometrial carcinoma. . Gynecol Oncol . 2004; ;95: : 762– 764 .
    [Google Scholar]
  4. [4]. Martin-Hirch PL., , Jarvis G. . Progestogens for endometrial cancer (Cochran Review) In: The Cochrane Library. 2004; Issue 2 .
  5. [5]. Phillips V., , Graham CT. . The effects of the Levonorgestrel intrauterine system (Mirena Coil) on endometrial morphology. .
  6. [6]. Nilsson   CG., , Houkkamaa   M. . Tissue concentrations of Levonorgestrel in women using a Levonorgestrel IUD. . Clin Endocrinol . 1982; ;17: : 529– 536 .
    [Google Scholar]
  7. [7]. Anderson   JK., , Rybo   G. . Levonorgestrel releasing intrauterine device in the treatment of menorrhagia. . Br J Obstet Gynecol . 1990; ;97: : 690– 694 .
    [Google Scholar]
  8. [8]. Hurskainen   R., , Paavonen   J. . Levonorgestrel releasing intrauterine system in the treatment of heavy menstrual bleeding. . CurrOpin Obstet Gynecol . 2004; ;16: : 487– 490 .
    [Google Scholar]
  9. [9]. Hurskainen   R., , Teperi   J., , Aalto   AM. . Levonorgestrel releasing intrauterine system or hysterectomy in the treatment of essential menorrhagia: predictors of outcome'Acta Obstet Gynaecol. . Scand . 2004; ;83: : 401– 403 .
    [Google Scholar]
  10. [10]. Critchley   HO., , Wang   H., , Jones   RL. . Morphological and functional features of endometrial decidualization following long- term intrauterine levonorgestrel delivery. . Hum Reprod . 1998; ;13: : 1218– 1224 .
    [Google Scholar]
  11. [11]. Maruo   T., , Ladag-Fernandez   JB., , Pakarinen   P. . Effects of the Levonorgestrel releasing intrauterine system on proliferation and apoptosis in the endometrium. . Hum Reprod . 2001; ;16: : 2103– 2108 .
    [Google Scholar]
  12. [12]. Zalel   Y., , Shulman   A., , Lidor   A. . The local progestational effect of the Levonorgestrel releasing intrauterine system: a sonographic and Doppler flow study. . Human Reprod . 2002; ;17: : 2878– 2880 .
    [Google Scholar]
  13. [13]. Bahamondes   L., , Ribeiro-Huguet   P., , de Andrade   KC. . Levonorgestrel releasing intrauterine system (Mirena) as a therapy for endometrial hyperplasia and carcinoma. . Acta Obstet Gynecol Scand . 2003; ;82: : 580– 582 .
    [Google Scholar]
  14. [14]. Grander   FJ., , Konje   JC., , Abrams   KR. . Endometrial protection from tamoxifen stimulated changes by a Levonorgestrel releasing intrauterine system: A randomized controlled trial. . Lancet . 2000; ;356: : 1711– 1717 .
    [Google Scholar]
  15. [15]. Vereide   AB., , Ames   M., , Straume   B. . Nuclear morphometric changes and therapy monitoring in patients with endometrial (hyperplasia: A study comparing effects of intrauterine levonorgestrel and systemic medroxyprogestrone. . Gynecol Oncol . 2003; ;91: 3 : 526– 533 .
    [Google Scholar]
  16. [16]. References from up to date [1] Endometrial cancer: Clinical features, diagnosis, and screening, [46], page 24 of 33 .
  17. [17]. References from up to date [11,12] Endometrial cancer: Clinical features, diagnosis,and screening, page 3 of 33 .
  18. [18]. From clinics in obstetrics and gynecology [13], December 1986, endometrial cancer, WTCREASMAN, page 690-691 .
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