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Volume 2007, Issue 1
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

Background: Ischemic optic neuropathy (ION) is the most common optic neuropathy in patients over the age of 50 years. It has variable clinical features, prognosis and associated risk factors. As far as we know there are no published data about ION from other Arabic countries.

Objective: We describe the clinical presentation, associated risk factors and the prognosis in patients presenting to our hospital and compare our findings with USA studies.

Methods: In a hospital-based prospective study, consecutive patients with a diagnosis of ION seen between January 2001 and December 2004 were included. Detailed neuro-ophthalmic evaluation, laboratory and neuroradiological investigations were performed in all patients. The patients were followed up at the clinic for mean period of 18 months.

Results: Twenty-six patients, 21 males and 5 females (male to female ratio 4.2:1) were enrolled. Mean age was 50.3years. The incidence was calculated as 1/100,000/year. Anterior ION was the commonest type (88%). Vascular risk factors were common; e. g. diabetes mellitus (DM) (58%), hypertension (HTN) (42%), hypercholesterolemia (10%). Prevalence of disc-at-risk (small or absent physiological cup) was (16%) and of temporal arteritis was uncommon (4%). Brain MRI showed ischemic vascular changes in (29%).

Conclusion: The incidence of ION in Qatar is much less and showed male predominance when compared with data from USA. Anterior non-arteritic ION is the commonest type. Vascular risk factors were more common while prevalence of disc at-risk and temporal arteritis was less compared to USA studies while DM was higher. Therefore, controlling risk factors may reduce the incidence of ION.

© 2007 Qaddoura, Hamad, Al Mansouri, El Shafei, Al Mannaei licensee Bloomsbury Qatar Foundation Journals.
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2007-06-01
2025-01-26
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References

  1. Hayreh SS. Anterior ischemic optic neuropathy: Differentiation of arteritic from non-arteritic type and its management. Eye. 1990; 4::25–41.
     [Google Scholar]
  2. Anrold AC. Pathogenesis of nonarteritic anterior ischemic optic neuropathy. J Neuroophthalmol. 2003; 23::157–163.
     [Google Scholar]
  3. Onda E, Ciojfi GA, Bacon DR, Van Buskirk EM. Microvasculature of the human optic nerve. Am J Ophthalmol. 1995; 120::92–102.
     [Google Scholar]
  4. Lee AG. Prothrombic and vascular risk factors in nonarteritic anterior ischemic optic neuropathy. Ophthalmology. 2000; 107::2231.
     [Google Scholar]
  5. Ischemic Optic Neuropathy Decompression Trial (IONDT). Research group/ Characteristics of patients with nonarteritic anterior ischemic optic neuropathy eligible for the ischemic optic neuropathy decompression trail. Arch Ophthalmol. 1996; 114::1366–1374.
     [Google Scholar]
  6. Hattenhauer MG, Leavitt JA, Hodge DO, et al., Incidence of nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol. 1997; 123::103–107.
     [Google Scholar]
  7. Johnson LN, Arnold AC. Incidence of nonarteritic and arteritic anterior ischemic optic neuropathy: Population based study in the State of Missouri and Los Angeles County, California. J Neuro-ophthalmol. 1994; 14::38–44.
     [Google Scholar]
  8. Chi T, Ritch R, Stickler D. Racial differences in optic nerve head parameters. Arch Ophthalmol. 1989; 107::836–839.
     [Google Scholar]
  9. Beck RW, Serivas GE, Hayreh SS:. Anterior ischemic optic neuropathy. IX Cup-to-disc ratio and its role in pathogenesis. Ophthalmology. 1987; 94::1503–1508.
     [Google Scholar]
  10. Liu NH, LaBree LD, Feldon SE, Rao NA. The epidemiology of giant cell arteritis: a 12-year retrospective study. Ophthalmology. 2001; 108::1145–1149.
     [Google Scholar]
  11. Crawley B, Scherer R, Langenberg P, Dickersin K. Participation in the Ischemic Optic Decompression. Trial: sex, race and age. Ophthalmic epidemiol. 1997 Sep; 4:3:157–173.
     [Google Scholar]
  12. Hayreh SS, Joos KM, Podhajsky PA, Long CR. Systemic diseases associated with nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol. 1994; 118::766–780.
     [Google Scholar]
  13. Jacobson DM, Vierkant RA, Belongia EA. Nonarteritic anterior ischemic optic neuropathy: a case -control study of potential risk factors. Arch Ophthalmol. 1997; 115::1403–1407.
     [Google Scholar]
  14. Deramo VA, Segott RC, Augsburger JJ, et al., Ischemic Optic Neuropathy as the first manifestation of elevated cholesterol levels in young patients. Ophthalmology. 2003; 110::1401–1045.
     [Google Scholar]
  15. Hayreh SS. Anterior ischemic optic neuropathy IV. Occurrence after cataract extraction. Arch Ophthalmol. 1980; 98::1410–1416.
     [Google Scholar]
  16. Shapira OM, Kimmel WA, Lindsey PS, Shahian DM. Anterior ischemic optic neuropathy after open heart operations. Ann Thorac Surg. 1966; 61::660–666.
     [Google Scholar]
  17. Cheng MA, Sigurdson W, Templehojf R, Lauryssen C. visual loss after spine surgery: a survey. Neurosurgery. 2000; 46::625–631.
     [Google Scholar]
  18. Egan R, Pomeranz H. Sildenafd (Viagra) associated anterior ischemic optic neuropathy. Arch Ophthalmol. 2000; 118::291–292.
     [Google Scholar]
  19. Chiari M, Manzoni GC, Van de Geijn EJ. Ischemic optic neuropathy after sumatriptan in a migraine with aura patient. Headache. 1994; 34::237–238.
     [Google Scholar]
  20. Nagra PK, Foroozan R, Savino PJ, et al., Amiodarone induced optic neuropathy. Brit J Ophthalmol. 2003; 87::420–422.
     [Google Scholar]
  21. Hayreh SS, Zimmerman MB, Podhajsky P, Alward WLM. Nocternal arterial hypotension and its role in optic head and ocular ischemic disorders. Am J Ophtahmol. 1994; 117::603–624.
     [Google Scholar]
  22. Mojon DS, Hedges TR, Ehrengerg B. Association between sleep apnoea syndrome and non arteritic anterior ischemic optic neuropathy. Arch ophthalmol. 2002; 120::601–605.
     [Google Scholar]
  23. Cox TA. Does levodopa improve visual function in NAION? Ophthalmology. 2000; 107::1431.
     [Google Scholar]
  24. Ischemic Optic Neuropathy Decompression Trial (IONDT) Research Group. Optic nerve decompression surgery for non-arteritic anterior ischemic optic neuropathy (NAION) is not effective and may be harmful. JAMA. 1995; 273::625–632.
     [Google Scholar]
  25. Kupersmith MJ, Frohman L, Sanderson M. Aspirin reduces the incidence of second eye NAION: a retrospective study. J Neuro-ophthalmol. 1997; 17::250–253.
     [Google Scholar]
  26. Beck RW, Hayreh SS, Podhajsky PA:. Aspirin therapy in non-arteritic anterior ischemic optic neuropathy. Am J Ophthalmol. 1997; 123::212–217.
     [Google Scholar]
  27. schemic I. Optic Neuropathy Decompression Trial Research Group: Ischemic Optic Neuropathy Decompression Trial: Twenty-four month update. Arch Ophthalmol. 2000; 118::793–798.
     [Google Scholar]
  28. Central statistical organization, State of Qatar, Doha-Qatar, Government of Qatar March 2004.
  29. Janet C Rucker, Valerie Biousse, Nancy J. newman: Ischemic Optic neuropathies. Current opinion Neurology. 2004; 17::27–35.
     [Google Scholar]
  30. Lawrence M, Buono MD, Rod Foroozan MD, Robert C, Sergott MD, Peter J, Savino MD. Nonarteritic anterior ischemic optic neuropathy. Current opinion in Neurology. 2002; 13::357–361.
     [Google Scholar]
  31. Hayreh SS, Podhajsky P. Visual field defects in anterior ischemic optic neuropathy. Doc Ophthalmol Proc Ser. 1979; 19::53–71.
     [Google Scholar]
  32. Fry CL, Carter JE, Kanter MD/. Anterior ischemic optic neuropathy is not associated with carotid artery atherosclerosis. Stroke. 1993; 24::539–542.
     [Google Scholar]
  33. Newman NJ, Scherer R, Langenberg P. The fellow eye in NAION: Report from the ischemic optic neuropathy decompression trial follow- up study. Am J Ophthalmol. 2002; 134::317–328.
     [Google Scholar]
/content/journals/10.5339/qmj.2007.1.13
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  • Article Type: Research Article
Keyword(s): clinical features, Ischemic optic neuropathy, Qatar and risk factors

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