1887
Volume 2023, Issue 1
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

Dystonia is defined as abnormal muscle contraction or twisting or repetitive movements that result in sustained and abnormal posture. Cervical dystonia (CD) is one form of dystonia that involves neck muscles and leads to involuntary movements of the neck and head. Many centrally acting medications such as antipsychotics and antidepressants were reported to cause acute dystonia, as they cause an extrapyramidal side effect.

We present the case of a female adult patient who had acute CD after 2 hours of the first dose of butamirate citrate, a centrally acting cough syrup, which rarely causes central nervous side effects. The patient developed neck pain, spasm, and rigidity, which worsened over time. She improved after the first dose of benztropine, an anticholinergic medication which is one of the treatment options for treating CD.

This case has shown that even in OTC medications with a good safety profile, critical side effects happen, which indicates that clinicians need to be more attentive to patient’s medication history prior to critical events such as acute CD.

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2023-02-07
2024-04-25
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References

  1. Morice A, Kardos P. Comprehensive evidence-based review on European antitussives. BMJ Open Respir Res. 2016 Aug 5; 3:(1):e000137. doi: 10.1136/bmjresp-2016-000137. PMID: 27547407; PMCID: PMC4985807.
    [Google Scholar]
  2. MIMSO. Butamirate: Indication, dosage, side effect, precaution. [Internet]. MIMS Philippines. 2022 [cited September 15, 2022]. Available from: https://www.mims.com/philippines/drug/info/butamirate.
    [Google Scholar]
  3. Mikó P. Butamirát citrát tartalmú csepp, szirup és késleltetett felszívódású tabletta magyarországi alkalmazása és biztonságossága [The use and safety of butamirate containing drops, syrup and depot tablets in Hungary]. Orv Hetil. 2005 Mar 27; 146:(13):609−12. PMID: 15856625.
    [Google Scholar]
  4. Beth E Crowner. Cervical dystonia: Disease profile and clinical management. Phys Ther. 2007 Nov 1; 87:(11):1511–26. doi: 10.2522/ptj.20060272.
    [Google Scholar]
  5. Rosales RL, Cuffe L, Regnault B, Trosch RM. Pain in cervical dystonia: mechanisms, assessment and treatment. Expert Rev Neurother. 2021 Oct; 21:(10):1125−34. doi: 10.1080/14737175.2021.1984230. PMID: 34569398.
    [Google Scholar]
  6. Loonen AJ, Ivanova SA. Neurobiological mechanisms associated with antipsychotic drug-induced dystonia. J Psychopharmacol. 2021 Jan; 35:(1):3−14. doi: 10.1177/0269881120944156. PMID: 32900259; PMCID: PMC7770213.
    [Google Scholar]
  7. van Harten PN, Hoek HW, Kahn RS. Acute dystonia induced by drug treatment. BMJ. 1999 Sep 4; 319:(7210):623−6. doi: 10.1136/bmj.319.7210.623. PMID: 10473482; PMCID: PMC1116493.
    [Google Scholar]
  8. Bayram E, Karakaya P, Topcu Y, Yis U, Hiz S. Acute cervical dystonia after the first dose of butamirate citrate. Pediatr Emerg Care. 2013 Jan; 29:(1):80−1. doi: 10.1097/PEC.0b013e31827b5635. PMID: 23283272.
    [Google Scholar]
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