1887
Volume 2022 Number 3
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

Vaccination proved useful in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection; however, there were instances of breakthrough infection occurred. Unvaccinated people are liable to have a severe infection while infection in vaccinated people has different outcomes, especially in relation to the type of vaccine. In this study, we aimed to assess the severity of the disease in unvaccinated people and the severity of break through infection in vaccinated people in relation to the type of vaccines available in Iraq. Two groups of Iraqi patients were studied, of which the first included 8,096 patients with COVID-19 pneumonia, including their vaccination status; and the second group included 1,124 patients who received the vaccine and developed the disease later. The severity of infection in these groups in relation to the three types of vaccine administered in Iraq was evaluated. Among the 8,096 patients who developed severe and critical COVID-19 pneumonia, most (96%) were not vaccinated. Among 1,124 patients who received the vaccine and developed breakthrough infection, Sinovac was associated with mild cases while Pfizer and AstraZeneca were associated with moderate and severe cases. Infection in unvaccinated people tended to be more severe and critical than that in vaccinated people, where it was mild or moderate. Of the vaccines given in Iraq, Sinopharm appeared to be superior to the other two in terms of breakthrough infection.

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2022-07-14
2024-11-06
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References

  1. Unidos US. COVID-19 [Internet]. [cited 2 March 2022]. Available from: https://www.unidosus.org/issues/health/covid19/.
  2. World Health Organization. Coronavirus disease (COVID-19) outbreak [Internet]. Available from: http://www.euro.who.int; health-emergencies > novel-cor.
  3. World Health Organization. WHO Director-General's opening remarks at the media briefing on COVID-19- 11 March 2020 [Internet]. WHO; 2020 [Accessed 14 March 2020]. Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19–-11-march-2020..
  4. Chan JF, To KK, Tse H, Jin DY, Yuen KY. Interspecies transmission and emergence of novel viruses: lessons from bats and birds. Trends Microbiology. 2013; 21:(10):544–55.
    [Google Scholar]
  5. Rabi FA, Al Zoubi MS, Kasasbeh GA, Alameh DM, Al-Nasser AD. SARS-CoV-2 and coronavirus disease 2019: what we know so far. Pathogens. 2020; 9:(3):231.
    [Google Scholar]
  6. World Health Organization. Naming the coronavirus disease (COVID-19) and the virus that causes it [Internet]. Available from: https://www.who.int; diseases > technical-guidance.
    [Google Scholar]
  7. WebMD. How Does Coronavirus Spread? [Internet] [Cited 15 March 2022]. Available from: https://www.webmd.com/lung/coronavirus-transmission-overview..
    [Google Scholar]
  8. Bosch BJ, van der Zee R, de Haan CA, Rottier PJ. The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex. Journal of Virology. 2003; 77:(16):8801–11.
    [Google Scholar]
  9. Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, Azman AS, Reich NG, Lessler J. The incubation period of coronavirus disease 2019 (COVID-19) from publicly reported confirmed cases: estimation and application. Annals of Internal Medicine. 2020; 172:(9):577–82.
    [Google Scholar]
  10. Cascella M, Rajnik M, Aleem A, Dulebohn SC, Di Napoli R. Features, Evaluation, and Treatment of Coronavirus (COVID-19). Treasure Island (FL): StatPearls Publishing; 2022. Available from: https://www.ncbi.nlm.nih.gov > books > NBK554776.
    [Google Scholar]
  11. Mayo Clinic. Coronavirus disease 2019 (COVID-19) Diagnosis and treatment. [Internet]. [cited 2 April 2022]. Available from: https://www.mayoclinic.org/diseases-conditions/coronavirus/diagnosis-treatment..
    [Google Scholar]
  12. Gavi.org. 10 things you should know about vaccine candidates [Internet]. [cited 2 March 2022]. Available from: https://www.gavi.org/vaccineswork..
  13. Ravichandran S, Coyle E, Klenow L, Tang J, Grubbs G, Liu S. Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits. Science Translational Medicine. 2020; 12:(550):eabc3539. doi:10.1126/scitranslmed.abc3539.
    [Google Scholar]
  14. Mascellino MT, Di Timoteo F, De Angelis M, Oliva A. Overview of the Main Anti-SARS-CoV-2 Vaccines: Mechanism of Action, Efficacy and Safety [Internet] 31 August 2021 Volume 2021:14 Pages 3459—3476 available https://doi.org/10.2147/IDR.S315727..
    [Google Scholar]
  15. Lauran Neergaard, AP Medical Writer. CDC Finds Unvaccinated 11 Times More Likely to Die of COVID[Internet]. Associated Press Sept. 10, 2021. Available from https://www.usnews.com/news/health-news/articles/2021-09-10..
    [Google Scholar]
  16. CDC. Unvaccinated Adults 11 Times More Likely To Die of COVID-19: Internet] Available from https://usnews.com>news>health news.
    [Google Scholar]
  17. CDC. Monitoring COVID-19 Vaccine Effectiveness [Internet]. [cited 17 March 2022]. Available from: https://www.cdc.gov/coronavirus/2019ncov/vaccines/effectiveness..
    [Google Scholar]
  18. Jeewandara C, Aberathna IS, Pushpakumara PD, et al. Antibody and T cell responses to Sinopharm/BBIBP-CorV in naïve and previously infected individuals in SriLanka. MedRxiv. 2021. https://www.medrxiv.org/content/10.1101/2021.07.15.21260621v1..
    [Google Scholar]
  19. Rajasekaran M. A comparison between Pfizer/BioNTech's and Sinopharm's SARS-CoV-2 vaccines. [Interent] [Cited 24 Oct 2021] Available from https://www.news-medical.net/news/20211024..
    [Google Scholar]
  20. Anthony king. how-do-the-covid-vaccines-measure-up-against-each-other [Internet]. [Cited 2 Feb 2022]. Available from: https://www.chemistryworld.com/news/explainerand omicron/4015153.article..
    [Google Scholar]
  21. Gavi.org. How effective are COVID-19 vaccines in the real-world? [Internet]. [cited 1 April 2022]. Available from: https://www.gavi.org/vaccineswork/how-effective-are-covid-19-vaccines-real-world..
    [Google Scholar]
  22. Comparison of COVID 19 Vaccines [Internet]. 2022 [cited 2 March 2022]. Available from: https://myacare.com/blog/comparison-of-covid-19-vaccines..
  23. Dashdorj NJ, Wirz OF, Röltgen K, Haraguchi E, Buzzanco AS 3rd, et al. Direct comparison of antibody responses to four SARS-CoV-2 vaccines in Mongolia. Cell Host Microbe. 2021 Dec 8; 29:(12):1738-1743.
    [Google Scholar]
  24. WHO. WHO lists additional COVID-19 vaccine for emergency use and issues interim policy recommendations [Internet] [Cited 7 May 2021]. Available from: https://www.who.int/news/item/07-05-202..
    [Google Scholar]
  25. Smriti Mallapaty - China's COVID vaccines have been crucial — now immunity is waning [Internet]. Nature. 14 October 2021. Available from https://www.nature.com/articles/d41586-021-02796..
  26. BBC news. Covid: China administers a billion vaccine doses. Published 20 June 2021. Available from https://www.bbc.com/news/world-asia-china..
    [Google Scholar]
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Keyword(s): AstraZenecaCOVID-19PfizerSinopharm and vaccination
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