1887
Volume 2013, Issue 1
  • EISSN: 2223-506X

Abstract

This study aims to synthesise a series of 1-thiocarbomyl pyrazolines, including 3-(3,4-dibromophenyl)-5-(substituted phenyl)-4,5-dihydro-1-pyrazole-1-carbothioamides, using solvent-free fly-ash:PTS catalyzed cyclization between chalcones and thiosemicarbazide, under microwave irradiation. Then to characterize them using analytical, physical and spectroscopic data.

Solvent-free microwave assisted cyclization was adopted for the synthesis of 1-thiocarbomyl, including 3-(3,4-dibromophenyl)-5-(substituted phenyl)-4,5-dihydro-1- pyrazole-1-carbothioamides, using fly-ash:PTS as the catalyst. They were characterised by IR, NMR and mass spectroscopic data. The infrared (IR) and nuclear magnetic resonance (NMR) spectral data was correlated with substituent constants, F and R parameters, using Hammett equation, to study the effect of substituents.

The yields of the synthesised chalcones were more than 85%. The spectral data of these 3-(3,4-dibromophenyl)-5-(substituted phenyl)-4,5-dihydro-1-pyrazole-1-carbothioamides had been correlated, using single and multi-linear regression analysis. These gave a satisfactory or fair degree of correlation with some parameters.

Easy handling, non-hazardous and environmentally benign cyclization method had been adopted for the synthesis of 1-thiocarbomyl pyrazolines using fly-ash:PTS as catalyst, with better yields. Some of the Hammett spectral correlations were found to be satisfactory, with the observed spectroscopic data.

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2013-07-01
2020-08-05
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