1887
Volume 2025, Issue 1
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Urinary incontinence (UI) is involuntary urine leakage, mainly due to a feeling of high pressure in the abdominal part, the immediate and urgent need for micturition, or both. Neurotrophins (NTs) are a family of peptides that play a role in the regulation of nerve cells. Their effects on the lower urinary tract organs may provide a perspective to understand the development and diagnosis of UI. This study aims to investigate NT levels to understand how these molecules change in multiparous premenopausal women who suffer from stress-related UI. The study also evaluates diagnostic and distinguishing capabilities of NTs for these disorders.

In this cross-sectional case–control study, multiparous premenopausal women underwent a urodynamic examination, a stress cough test, and were evaluated with an International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). Participants were divided into three groups: 29 healthy women in the control group and two patient groups consisting of 26 women diagnosed with stress urinary incontinence (SUI) and 33 women diagnosed with mixed urinary incontinence (MUI). Nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) levels in serum were measured by enzyme-linked immunosorbent assay. The body mass index (BMI) and ICIQ-SF scores of the patients were also calculated. The data obtained were compared between the groups. Receiver-operating characteristic analysis was performed to determine the role of NTs in diagnosing UI.

The result showed that serum NGF and NT-3 levels were significantly low in both incontinence subtypes compared to the control group ( < 0.05). BMI scores and number of vaginal deliveries were higher in incontinence subtypes compared to the control group, and ICIQ-SF scores were higher in the MUI group.

The differences in serum NGF and NT-3 levels were observed in multiparous premenopausal patients with UI. There was a decrease in serum NGF levels in MUI patients and serum NT-3 levels in SUI patients. Although the changes in serum NGF and NT-3 levels were significant, their discriminatory potential was weak or moderate.

© 2025 Ünal, Çöllüoğlu, Erdem, Özbas¸, Özdemir, licensee HBKU Press.
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References

  1. Haylen BT, de Ridder D, Freeman RM, Swift SE, Berghmans B, Lee J, et al. An international urogynecological association (IUGA)/international continence society (ICS) joint report on the terminology for female pelvic floor dysfunction. Neurourology and Urodynamics. 2010; 29:(1):4-20.
     [Google الباحث العلمي]
  2. Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society. Urology. 2003; 61:(1):37-49.
     [Google الباحث العلمي]
  3. de Groat WC, Griffiths D, Yoshimura N. Neural Control of the Lower Urinary Tract. Comprehensive Physiology. p. 327-96.
     [Google الباحث العلمي]
  4. Anderson KE. Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev. 1993; 45:(3):253-308.
     [Google الباحث العلمي]
  5. Keast JR, Kawatani M, De Groa WC. Sympathetic modulation of cholinergic transmission in cat vesical ganglia is mediated by alpha 1- and alpha 2-adrenoceptors. Am J Physiol. 1990; 258:(1 Pt 2):R44-50.
     [Google الباحث العلمي]
  6. Andersson KE, Arner A. Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol Rev. 2004; 84:(3):935-86.
     [Google الباحث العلمي]
  7. Matsui M, Motomura D, Fujikawa T, Jiang J, Takahashi S, Manabe T, et al. Mice lacking M2 and M3 muscarinic acetylcholine receptors are devoid of cholinergic smooth muscle contractions but still viable. J Neurosci. 2002; 22:(24):10627-32.
     [Google الباحث العلمي]
  8. Frias B, Lopes T, Pinto R, Cruz F, Cruz CD. Neurotrophins in the lower urinary tract:becoming of age. Curr Neuropharmacol. 2011; 9:(4)553-8.
     [Google الباحث العلمي]
  9. Huang EJ, Reichardt LF. Neurotrophins:roles in neuronal development and function. Annu Rev Neurosci. 2001;24677-736.
     [Google الباحث العلمي]
  10. Cruz CD. Neurotrophins in bladder function: what do we know and where do we go from here? Neurourol Urodyn. 2014; 33:(1):39-45.
     [Google الباحث العلمي]
  11. Steers WD, Tuttle JB. Mechanisms of Disease:the role of nerve growth factor in the pathophysiology of bladder disorders. Nat Clin Pract Urol. 2006; 3:(2)101-10.
     [Google الباحث العلمي]
  12. Song Q-X, Chermansky CJ, Birder LA, Li L, Damaser MS. Brain-derived neurotrophic factor in urinary continence and incontinence. Nature Reviews Urology. 2014; 11:(10):579-88.
     [Google الباحث العلمي]
  13. Pezet S, Malcangio M, McMahon SB. BDNF: a neuromodulator in nociceptive pathways? Brain Research Reviews. 2002; 40:(1):240-9.
     [Google الباحث العلمي]
  14. Vizzard MA. Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction. Exp Neurol. 2000; 161:(1):273-84.
     [Google الباحث العلمي]
  15. Hsu THS, Rackley RR, Appell RA. THE SUPINE STRESS TEST:A SIMPLE METHOD TO DETECT INTRINSIC URETHRAL SPHINCTER DYSFUNCTION. The Journal of Urology. 1999; 162:(2)460-3.
     [Google الباحث العلمي]
  16. ÇETİNEL B, ÖZKAN B, CAN G. ICIQ-SF Türkçe versiyonu validasyon (geçerlilik) çalışması. Türk Üroloji Dergisi/Turkish Journal of Urology. 2004; 30:(3):332-8.
     [Google الباحث العلمي]
  17. Mostafaei H, Sadeghi-Bazargani H, Hajebrahimi S, Salehi-Pourmehr H, Ghojazadeh M, Onur R, et al. Prevalence of female urinary incontinence in the developing world:A systematic review and meta-analysis—A Report from the Developing World Committee of the International Continence Society and Iranian Research Center for Evidence Based Medicine. Neurourology and Urodynamics. 2020; 39:(4)1063-86.
     [Google الباحث العلمي]
  18. Liu HT, Chen CY, Kuo HC. Urinary nerve growth factor levels in overactive bladder syndrome and lower urinary tract disorders. J Formos Med Assoc. 2010; 109:(12):862-78.
     [Google الباحث العلمي]
  19. Liu H-T, Chancellor MB, Kuo H-C. Urinar nerve growth factor level could be a biomarker in the differential diagnosis of mixed urinary incontinence in women. BJU International. 2008; 102:(10):1440-4.
     [Google الباحث العلمي]
  20. Yuan X, Balog BM, Lin DL, Hanzlicek B, Kuang M, Yan H, et al. Brain-Derived Neurotrophic Factor Is an Important Therapeutic Factor in Mesenchymal Stem Cell Secretions for Treatment of Traumatic Peripheral Pelvic Injuries. Frontiers in Cellular Neuroscience. 2022;16.
     [Google الباحث العلمي]
  21. Pan HQ, Kerns JM, Lin DL, Sypert D, Steward J, Hoover CR, et al. Dual simulated childbirth injury delays anatomic recovery. Am J Physiol Renal Physiol. 2009; 296:(2):F277-83.
     [Google الباحث العلمي]
  22. Jiang HH, Gill BC, Dissaranan C, Zutshi M, Balog BM, Lin D, et al. Effects of acute selective pudendal nerve electrical stimulation after simulated childbirth injury. Am J Physiol Renal Physiol. 2013; 304:(3):F239-47.
     [Google الباحث العلمي]
  23. Jiang HH, Gustilo-Ashby AM, Salcedo LB, Pan HQ, Sypert DF, Butler RS, et al. Electrophysiological function during voiding after simulated childbirth injuries. Exp Neurol. 2009; 215:(2):342-8.
     [Google الباحث العلمي]
  24. Balog BM, Deng K, Askew T, Kuang M, Hanzlicek B, Damaser MS. Brain derived neurotrophic factor mediates accelerated recovery of regenerative electrical stimulation in an animal model of stress urinary incontinence. Experimental Neurology. 2021;343:113781.
     [Google الباحث العلمي]
  25. Bagińska J, Sadowska E, Korzeniecka-Kozerska A. An Examination of the Relationship between Urinary Neurotrophin Concentrations and Transcutaneous Electrical Nerve Stimulation (TENS) Used in Pediatric Overactive Bladder Therapy. J Clin Med. 2021; 10:(14).
     [Google الباحث العلمي]
  26. Dewulf K, Abraham N, Lamb LE, Griebling TL, Yoshimura N, Tyagi P, et al. Addressing challenges in underactive bladder:recommendations and insights from the Congress on Underactive Bladder (CURE-UAB). International Urology and Nephrology. 2017; 49:(5)777-85.
     [Google الباحث العلمي]
  27. Elia G, Dye TD, Scariati PD. Body mass index and urinary symptoms in women. Int Urogynecol J Pelvic Floor Dysfunct. 2001; 12:(6):366-9.
     [Google الباحث العلمي]
  28. Townsend MK, Danforth KN, Rosner B, Curhan GC, Resnick NM, Grodstein F. Body mass index and urinary symptoms in women. Obstet Gynecol. 2007; 110:(2 Pt 1):346-53.
     [Google الباحث العلمي]
  29. Hunskaar S. A systematic review of overweight and obesity as risk factors and targets for clinical intervention for urinary incontinence in women. Neurourol Urodyn. 2008; 27:(8):749-57.
     [Google الباحث العلمي]
  30. Klovning A, Avery K, Sandvik H, Hunskaar S. Comparison of two questionnaires for assessing the severity of urinary incontinence:The ICIQ-UI SF versus the incontinence severity index. Neurourology and Urodynamics. 2009; 28:(5)411-5.
     [Google الباحث العلمي]
  31. Dedicação AC, Haddad M, Saldanha MES, Driusso P. Comparison of quality of life for different types of female urinary incontinence Brazilian Journal of Physical Therapy. 2009;13.
  32. Grodstein F, Fretts R, Lifford K, Resnick N, Curhan G. Association of age, race, and obstetric history with urinary symptoms among women in the Nurses’ Health Study. American Journal of Obstetrics and Gynecology. 2003; 189:(2):428-34.
     [Google الباحث العلمي]
  33. Rajavuori A, Repo JP, Häkkinen A, Palonen P, Multanen J, Aukee P. Maternal risk factors of urinary incontinence during pregnancy and postpartum:A prospective cohort study. Eur J Obstet Gynecol Reprod Biol X. 2022; 13:100138.
     [Google الباحث العلمي]
  34. Hannah ME, Hannah WJ, Hodnett ED, Chalmers B, Kung R, Willan A, et al. Outcomes at 3 months after planned cesarean vs planned vaginal delivery for breech presentation at term:the international randomized Term Breech Trial. Jama. 2002; 287:(14)1822-31.
     [Google الباحث العلمي]
  35. Barbosa AM, Marini G, Piculo F, Rudge CV, Calderon IM, Rudge MV. Prevalence of urinary incontinence and pelvic floor muscle dysfunction in primiparae two years after cesarean section: cross-sectional study. Sao Paulo Med J. 2013; 131:(2):95-9.
     [Google الباحث العلمي]
  36. Dwyer PL. Differentiating stress urinary incontinence from urge urinary incontinence. Int J Gynaecol Obstet. 2004; 86: Suppl 1:S17-24.
     [Google الباحث العلمي]
  37. Vijaya G, Cartwright R, Bhide A, Derpapas A, Fernando R, Khullar V. Reliability and validity of urinary nerve growth factor measurement in women with lower urinary tract symptoms. Neurourol Urodyn. 2016; 35:(8):944-8.
     [Google الباحث العلمي]
/content/journals/10.5339/qmj.2025.3
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The relationship of neurotrophin levels with stress-induced urinary incontinence in multiparous premenopausal women
Qatar Medical Journal 2025, 3 (٢٠٢٥); https://doi.org/10.5339/qmj.2025.3
/content/journals/10.5339/qmj.2025.3
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  • نوع المستند: Research Article
الموضوعات الرئيسية Menopause, mixed urinary incontinence, multiparous, neurotrophins, stress urinary incontinence and urogynecology

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