1887
Volume 2026, Issue 1
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

Exertional heatstroke (EHS) is a medical emergency characterized by an elevated core body temperature and central nervous system dysfunction. If not identified and treated early, it can rapidly progress to multiple organ dysfunction. Although EHS is common among athletes and military personnel, it may also affect vulnerable individuals during mass gatherings in extreme environmental conditions, such as the Hajj pilgrimage.

We report a fatal case of EHS in a previously healthy 56-year-old male pilgrim during the 2024 Hajj season. The patient collapsed after prolonged physical exertion in high ambient temperatures and was initially misdiagnosed with hemorrhagic stroke, resulting in an 8-h delay in definitive management. Upon arrival at the Indonesian Hajj Health Clinic in Mecca, he presented with coma, hyperthermia (42°C), metabolic acidosis, acute liver failure, coagulopathy, and acute kidney injury requiring hemodialysis. Despite intensive care, including cooling interventions and organ support, the patient died on the fifth day of admission due to refractory hyperthermia and progressive organ failure.

This case highlights the diagnostic challenges of EHS in high-risk environments, where its symptoms may mimic other critical conditions such as stroke. Delays in initiating rapid cooling and systemic support can significantly worsen the prognosis. Early recognition, accurate differentiation from other acute neurologic conditions, and aggressive intervention are essential to reduce EHS-related morbidity and mortality.

Timely diagnosis and immediate cooling are crucial to improving outcomes in EHS. Preventive education, heat-risk awareness, and clinical preparedness are essential during mass gatherings to reduce fatalities associated with heat-related illnesses.

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2026-02-06

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References

  1. Epstein Y, Yanovich R. Heatstroke. N Engl J Med. 2019 Jun 20; 380:(25):2449–59. https://doi.org/10.1056/NEJMra1810762
    [Google Scholar]
  2. Memish ZA, Zumla A, Parker S. Heat-related deaths during the 2024 Hajj pilgrimage. J Travel Med. 2024 Aug 3; 31:(6):taae096. https://doi.org/10.1093/jtm/taae096
    [Google Scholar]
  3. Elbashir H, Saeed L, Sabir D, Morgom M, Abuazab Y, Madebo T, et al. From heat stroke to multi-organ failure: A survivor’s case report. Cureus. 2023 Nov 18; 15:(11):e48984. https://doi.org/10.7759/cureus.48984
    [Google Scholar]
  4. Layton JB, Li W, Yuan J, Gilman JP, Horton DB, Setoguchi S. Heatwaves, medications, and heat-related hospitalization in older Medicare beneficiaries with chronic conditions. PLoS One. 2020 Dec 10; 15:(12):e0243665. https://doi.org/10.1371/journal.pone.0243665
    [Google Scholar]
  5. Yezli S, Ehaideb S, Yassin Y, Alotaibi B, Bouchama A. Escalating climate-related health risks for Hajj pilgrims to Mecca. J Travel Med. 2024 Jun 3; 31:(4):taae042. https://doi.org/10.1093/jtm/taae042
    [Google Scholar]
  6. Almuzaini Y, Alburayh M, Alamri F, Alahmari A, Alamri F, Sabbagh AY, et al. Mitigation strategies for heat-related illness during mass gatherings: Hajj experience. Front Public Health. 2022 Aug 18: 10:957576. https://doi.org/10.3389/fpubh.2022.957576
    [Google Scholar]
  7. Minister S health. Saudi Health Minister says 1,301 people died during Hajj, 83 Pct were without permits [online]. 2024. [Accessed 30 May 2025]. Available from: https://english.alarabiya.net/News/saudi-arabia/2024/06/23/saudi-health-minister-says-1-301-died-during-hajj
    [Google Scholar]
  8. Schmidt S. Precision public health opportunity: Heat-associated mortality greater among Pilgrims during Hajj. Environ Health Perspect. 2023 Jun; 131:(6):64001. https://doi.org/10.1289/EHP13055
    [Google Scholar]
  9. Al-Tawfiq JA, Memish ZA. Heat and mass gatherings: What is needed? Mass Gathering Medicine. Volume 1:, September 2024, https://doi.org/10.1016/j.mgmed.2024.100006
    [Google Scholar]
  10. Chen P, Billiar T. Gut microbiota and multiple organ dysfunction syndrome: MODS. Adv Exp Med Biol. 2020; 1238:195–202. https://doi.org/10.1007/978-981-15-2385-4_11
    [Google Scholar]
  11. Merchant RK, Grundstein A, Yeargin S, Emerson D. Exertional heat illnesses in marching band artists: A case series. Int J Biometeorol. 2021 Dec; 65:(12):2181–8. https://doi.org/10.1007/s00484-021-02183-0
    [Google Scholar]
  12. Kaewput W, Thongprayoon C, Petnak T, Cato LD, Chewcharat A, Boonpheng B, et al. Inpatient burden and mortality of heatstroke in the United States. Int J Clin Pract. 2021 Apr; 75:(4):e13837. https://doi.org/10.1111/ijcp.13837
    [Google Scholar]
  13. Woitok BK, Bahmad S, Lindner G. A case of exertional heat stroke complicated by hjypoxic hepatitis. Case Rep Emerg Med. 2020 Mar 30; 2020:8724285. https://doi.org/10.1155/2020/8724285
    [Google Scholar]
  14. Bouchama A, Abuyassin B, Lehe C, Laitano O, Jay O, O’Connor FG, et al. Classic and exertional heatstroke. Nat Rev Dis Primers. 2022 Feb 3; 8:(1):8. https://doi.org/10.1038/s41572-021-00334-6
    [Google Scholar]
  15. Miller KC, Casa DJ, Adams WM, Hosokawa Y, Cates J, Emrich C, et al. Roundtable on preseason heat safety in secondary school athletics: Prehospital care of patients with exertional heat stroke. J Athl Train. 2021 Apr 21; 56:(4):372–82. https://doi.org/10.4085/1062-6050-0173.20
    [Google Scholar]
  16. Martin KR, Naiman M, Espinoza M. Using esophageal temperature management to treat severe heat stroke: A case report. J Neurosci Nurs. 2020 Feb; 52:(1):9–13. https://doi.org/10.1097/JNN.0000000000000488
    [Google Scholar]
  17. Adnan Bukhari H. A systematic review on outcomes of patients with heatstroke and heat exhaustion. Open Access Emerg Med. 2023 Sep 22: 15:343–54. https://doi.org/10.2147/OAEM.S419028.
    [Google Scholar]
  18. Gamage PJ, Fortington LV, Finch CF. Epidemiology of exertional heat illnesses in organised sports: A systematic review. J Sci Med Sport. 2020 Aug; 23:(8):701–9. https://doi.org/10.1016/j.jsams.2020.02.008
    [Google Scholar]
  19. Lin JS, Zaffar D, Muhammad H, Ting PS, Woreta T, Kim A, et al. Exertional heat stroke-induced acute liver failure and liver transplantation. ACG Case Rep J. 2022 Jul 12; 9:(7):e00820. https://doi.org/10.14309/crj.0000000000000820
    [Google Scholar]
  20. Steinberg AW, Zeba F, Rassias AJ, Mota P. A 56-year-old man with progressive subacute hypoxemia. Chest. 2023 Dec; 164:(6):e169–72. https://doi.org/10.1016/j.chest.2023.06.042
    [Google Scholar]
  21. Schlader ZJ, Davis MS, Bouchama A. Biomarkers of heatstroke-induced organ injury and repair. Exp Physiol. 2022 Oct; 107:(10):1159–71. https://doi.org/10.1113/EP090142
    [Google Scholar]
  22. Matsumoto S, Kuno T, Mikami T, Takagi H, Ikeda T, Briasoulis A, et al. Effect of cooling methods and target temperature on outcomes in comatose patients resuscitated from cardiac arrest: Systematic review and network meta-analysis of randomized trials. Am Heart J. 2023 Feb: 256:73–84. https://doi.org/10.1016/j.ahj.2022.11.005
    [Google Scholar]
  23. Shi L, Wang B, Wu Q, Yang J, Wang L, Wan D, et al. Heatstroke: A multicenter study in Southwestern China. Front Public Health. 2024 Apr 17: 12:1349753. https://doi.org/10.3389/fpubh.2024.1349753
    [Google Scholar]
  24. Rajagopalan S, Sarwal A. Neuromonitoring in critically ill patients. Crit Care Med. 2023 Apr 1; 51:(4):525–42. https://doi.org/10.1097/CCM.0000000000005809
    [Google Scholar]
  25. Nabil Ramadan E, Ahmed Ibrahim Zahra N. Pilgrims’ awareness regarding health hazards during Hajj. Egypt J Heal Care. 2016 7: 3:256–70. https://doi.org/10.21608/ejhc.2016.68479
    [Google Scholar]
  26. Almuzaini Y, Alburayh M, Alahmari A, Alamr F, Mukhtar N, Alabdullatif L, et al. Characteristics and distribution of heat-related illnesses during Hajj 2022. Saudi J Er Med. 2024; 5:(2):141–7. https://doi.org/10.24911/SJEMed.72-1680174179
    [Google Scholar]
  27. Casa DJ, DeMartini JK, Bergeron MF, Csillan D, Eichner ER, Lopez RM, et al. National athletic trainers’ association position statement: Exertional heat illnesses. J Athl Train. 2015 Sep; 50:(9):986–1000. https://doi.org/10.4085/1062-6050-50.9.07
    [Google Scholar]
  28. Puga TB, Schafer J, Scigliano N, Thiel G, Treffer K. Exertional heat illness: A yearly preventable cause of ilness and death in athletes. Int J Sport Exercise Health Res. 2022 Dec; 6:(2). https://doi.org/10.31254/sportmed.6201
    [Google Scholar]
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  • Article Type: Case Report
Keyword(s): critical caredelayed diagnosisHajj pilgrimageheatstrokemass gathering and organ dysfunction
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