1887
Volume 2011, Issue 2
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

This case report illustrates an acute presentation of hemoptysis in a 21-year-old man from a TB endemic region. Further clinical evaluation resulted in extensive hypercoagulability complications of nephritic syndrome due to idiopathic membranous glomerulonephritis (MGN.) This emphasizes that proteinuria seen at a subnephrotic level, or on urine dipstick in a setting where glomerular disease might not be initially apparent, may warrant a keener look.

Loading

Article metrics loading...

/content/journals/10.5339/qmj.2011.2.22
2011-12-01
2019-08-20
Loading full text...

Full text loading...

References

  1. 1. Braden   Gl., , Mulhern   JG. . Changing incidence of glomerular diseases in adult. . Am J Kidney Dis . 2000; ;35: : 878 .
    [Google Scholar]
  2. 2. Rivera   F., , Lopez-Gomez   JM. . Clinicopathologic correlations of renal pathology in spain. . Kidney Int . 2004; ;66: : 898 .
    [Google Scholar]
  3. 3. Korbet   SM., , Genchi   RM. . The racial prevalence of glomerular lesions in nephrotic adults. . Am J Kidney Dis . 1996; ;27: : 647 .
    [Google Scholar]
  4. 4. Haas   M., , Meehan   SM. . Changing etiologies of unexplained adult nephrotic syndrome: A comparison of renal biopsy findings from 1976–1979 and 1995–1997. . Am J Kidney Dis . 1997; ;30: : 621 .
    [Google Scholar]
  5. 5. Zent   R., , Negai   R. . Idiopathic membranous nephropathy in elderly. . Nephro Dial Transplant . 1993; ;8: : 1321 .
    [Google Scholar]
  6. 6. Conttan   DC. . Idiopathic membranous glomerulonephritis. . Kidney Int . 2001; ;59: : 1983 .
    [Google Scholar]
  7. 7. du Buf-vereijken   PW., , Branten   AJ. . Idiopathic membranous nephropathy: Outline and rationale of a treatment strategy. . Am J Kidney Dis . 2005; ;46: : 1012 .
    [Google Scholar]
  8. 8. Wagoner   RD., , Stanson   AW. . Renal vein thrombosis in idiopathic membranous glomerulopathy and nephrotic syndrome: Incidence and significance. . Kidney Int . 1983; ;23: : 368 .
    [Google Scholar]
  9. 9. Llach   F., , Arieff   AI. . Renal vein thrombosis and nephrotic syndrome. A prospective study of 36 adult patients. . Ann Intern Med . 1975; ;83: : 8 .
    [Google Scholar]
  10. 10. Velasquez   FFf., , Garcia   PN. . Idiopathic nephrotic syndrome of the adult with asymptomatic thrombosis of the renal vein. . Am J Nephrol . 1988; ;8: : 457 .
    [Google Scholar]
  11. 11. Llach   F., , Papper   S. . The clinical spectrum of renal vein thrombosis: acute and chronic. . Am J Med . 1980; ;69: : 819 .
    [Google Scholar]
  12. 12. Kuhlmann   U., , Steurer   J. . Platelet aggregation and beta-thromboglobulin levels in nephrotic patients with and without thrombosis. . Clin Nephrol . 1981; ;15: : 229 .
    [Google Scholar]
  13. 13. Kauffmann   RH., , Veltkamp   JJ. . Acquired antithrombin III deficiency and thrombosis in the nephrotic syndrome. . Am J Med . 1978; ;65: : 607 .
    [Google Scholar]
  14. 14. Cameron   JS. . Coagulation and thromboembolic complications in nephrotic syndrome. . Adv Nephrol Necker Hosp . 1984; ;13: : 75 .
    [Google Scholar]
  15. 15. Singhal   R., , Brimble   KS. . Thromboembolic complications in nephritic sydndrome: pathophysiology and clinical management. . Thromb Res . 2006; ;118: : 397 .
    [Google Scholar]
  16. 16. Llach   F. . Hypercoagulability renal vein thrombosis, and other thrombotic complications of nephrotic syndrome. . Kidney Int . 1985; ;28: : 429 .
    [Google Scholar]
  17. 17. Fadi   K., , Reiad   N. . Venous thrombo-embolism in patients hospitalized for nephrotic syndrome. . Am J Med . 2008; ;121: : 226 .
    [Google Scholar]
  18. 18. Kendall   AG., , Lohmann   RC. . Nephrotic syndrome. A hypercoagulable state. . Arch Intern Med . 1971; ;127: : 1021 .
    [Google Scholar]
  19. 19. Andrassy   K., , Oertel   PJ. . Thromboembolic complications and hemostatis in the nephrotic syndrome: Is there a difference between children and adults?.   Proc Eur Dial Transplant Assoc . 1982; ;19: : 597 .
    [Google Scholar]
  20. 20. Mehls   0., , Andrassy   K. . Hemostasis and thromboembolism in children with nephrotic syndrome: Differences from adults. . J Pediatr . 1987; ;110: : 862 .
    [Google Scholar]
  21. 21. Sagripanti   A., , Barsotti   G. . Hypercoagulability, intraglomerular coagulation and thromboembolism in nephrotic syndrome. . Nephron . 1995; ;70: : 271 .
    [Google Scholar]
  22. 22. Chen   Ty., , Hang   CC. . Hemostatic molecular markers in nephrotic syndrome. . Am J Hematol . 1993; ;44: : 276 .
    [Google Scholar]
  23. 23. Niaudet   P. . Genetic forms of nephrotic syndrome. . Pediatr Nephrol . 2004; ;19: : 1313 .
    [Google Scholar]
  24. 24. Cosio   FG., , Harker   C. . Plasma concentration of natural anticoagulants protein C and protein S in patients with proteinuria. . J Lab Clin Med . 1985; ;106: : 218 .
    [Google Scholar]
  25. 25. Marchleidt   C., , Mettang   T. . Multifactorial genesis of enhanced platelet aggregation in patients with nephrotic syndrome. . Kidney Int . 1989; ;36: : 1119 .
    [Google Scholar]
  26. 26. Joshida   N., , Aoki   N. . Release of arachidonic acid from platelets: A key role for the potentiation ofplatelet aggregability in normal subjects as well as in those with nephrotic syndrome. . Blood . 1978; ;52: : 969 .
    [Google Scholar]
  27. 27. Majumdar   A., , Wheeler   DC. . Lipid abnormalities in renal disease. . J RSoc Med . 2000; ;93: : 178 .
    [Google Scholar]
  28. 28. Joven   J., , Villabona   C. . Abnormalities of lipoprotein metabolism in patients with the nephrotic syndrome. . N Engl J Med . 1990; ;323: : 579 .
    [Google Scholar]
  29. 29. Appel   G. . Lipid abnormalities in renal disease. . Kidney Int . 1991; ; : 169 .
    [Google Scholar]
  30. 30. Wheeler   DC., , Bernard   DB. . Lipid abnormalities in nephrotic syndrome: causes, consequences and treatment. . Am J Kidney Dis . 1994; ;23: : 331 .
    [Google Scholar]
  31. 31. Saland   JM., , Ginsberg   H. . Dyslipidemia in pediatric renal disease: Epidemiology, pathophysiology and clinical management. . CurrOpin Pediatr . 2002; ;14: : 197 .
    [Google Scholar]
  32. 32. Rabelink   TJ., , Zwaginga   JJ. . Thrombosis and hemostasis in renal disease. . Kidney Int . 1994; ;46: : 287 .
    [Google Scholar]
  33. 33. Cattran   DC., , Gerall   BA. . Cyclosporine in patients with steroid resistant membranous nephropathy: A randomized trial. . Kidney Int . 2001; ;59: : 1484 .
    [Google Scholar]
  34. 34. Cattran   DC., , Pei   Y. . Validation of a predictive model of idiopathic membranous nephropathy: It's clinical and research implications. . Kidney Int . 1997; ;51: : 901 .
    [Google Scholar]
  35. 35. Pei   Y., , Cattran   DC. . Predicting chronic renal insufficiency in idiopathic membranous glomerulonephritis. . Kidney Int . 1992; ;42: : 960 .
    [Google Scholar]
  36. 36. Philibert   D., , Cattran   D. . Remission of proteinuria in primary glomerulonephritis: We know the goal but do we know the price. . Nat Clin Pract Nephrol . 2008; ;4: : 550 .
    [Google Scholar]
  37. 37. Alexopoulos   E., , Papagianni   A. . Induction and longterm treatment with cyclosporine in membranous nephropathy with nephritic syndrome. . Nephrol Dial Transplant . 2006; ;21: : 3127 .
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5339/qmj.2011.2.22
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error