1887
Volume 2011, Issue 2
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

This case report illustrates an acute presentation of hemoptysis in a 21-year-old man from a TB endemic region. Further clinical evaluation resulted in extensive hypercoagulability complications of nephritic syndrome due to idiopathic membranous glomerulonephritis (MGN.) This emphasizes that proteinuria seen at a subnephrotic level, or on urine dipstick in a setting where glomerular disease might not be initially apparent, may warrant a keener look.

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2011-12-01
2020-09-28
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References

  1. Braden Gl, Mulhern JG. Changing incidence of glomerular diseases in adult. Am J Kidney Dis. 2000; 35::878.
    [Google Scholar]
  2. Rivera F, Lopez-Gomez JM. Clinicopathologic correlations of renal pathology in spain. Kidney Int. 2004; 66::898.
    [Google Scholar]
  3. Korbet SM, Genchi RM. The racial prevalence of glomerular lesions in nephrotic adults. Am J Kidney Dis. 1996; 27::647.
    [Google Scholar]
  4. Haas M, Meehan SM. Changing etiologies of unexplained adult nephrotic syndrome: A comparison of renal biopsy findings from 1976–1979 and 1995–1997. Am J Kidney Dis. 1997; 30::621.
    [Google Scholar]
  5. Zent R, Negai R. Idiopathic membranous nephropathy in elderly. Nephro Dial Transplant. 1993; 8::1321.
    [Google Scholar]
  6. Conttan DC. Idiopathic membranous glomerulonephritis. Kidney Int. 2001; 59::1983.
    [Google Scholar]
  7. du Buf-vereijken PW, Branten AJ. Idiopathic membranous nephropathy: Outline and rationale of a treatment strategy. Am J Kidney Dis. 2005; 46::1012.
    [Google Scholar]
  8. Wagoner RD, Stanson AW. Renal vein thrombosis in idiopathic membranous glomerulopathy and nephrotic syndrome: Incidence and significance. Kidney Int. 1983; 23::368.
    [Google Scholar]
  9. Llach F, Arieff AI. Renal vein thrombosis and nephrotic syndrome. A prospective study of 36 adult patients. Ann Intern Med. 1975; 83::8.
    [Google Scholar]
  10. Velasquez FFf, Garcia PN. Idiopathic nephrotic syndrome of the adult with asymptomatic thrombosis of the renal vein. Am J Nephrol. 1988; 8::457.
    [Google Scholar]
  11. Llach F, Papper S. The clinical spectrum of renal vein thrombosis: acute and chronic. Am J Med. 1980; 69::819.
    [Google Scholar]
  12. Kuhlmann U, Steurer J. Platelet aggregation and beta-thromboglobulin levels in nephrotic patients with and without thrombosis. Clin Nephrol. 1981; 15::229.
    [Google Scholar]
  13. Kauffmann RH, Veltkamp JJ. Acquired antithrombin III deficiency and thrombosis in the nephrotic syndrome. Am J Med. 1978; 65::607.
    [Google Scholar]
  14. Cameron JS. Coagulation and thromboembolic complications in nephrotic syndrome. Adv Nephrol Necker Hosp. 1984; 13::75.
    [Google Scholar]
  15. Singhal R, Brimble KS. Thromboembolic complications in nephritic sydndrome: pathophysiology and clinical management. Thromb Res. 2006; 118::397.
    [Google Scholar]
  16. Llach F. Hypercoagulability renal vein thrombosis, and other thrombotic complications of nephrotic syndrome. Kidney Int. 1985; 28::429.
    [Google Scholar]
  17. Fadi K, Reiad N. Venous thrombo-embolism in patients hospitalized for nephrotic syndrome. Am J Med. 2008; 121::226.
    [Google Scholar]
  18. Kendall AG, Lohmann RC. Nephrotic syndrome. A hypercoagulable state. Arch Intern Med. 1971; 127::1021.
    [Google Scholar]
  19. Andrassy K, Oertel PJ. Thromboembolic complications and hemostatis in the nephrotic syndrome: Is there a difference between children and adults? Proc Eur Dial Transplant Assoc. 1982; 19::597.
    [Google Scholar]
  20. Mehls 0, Andrassy K. Hemostasis and thromboembolism in children with nephrotic syndrome: Differences from adults. J Pediatr. 1987; 110::862.
    [Google Scholar]
  21. Sagripanti A, Barsotti G. Hypercoagulability, intraglomerular coagulation and thromboembolism in nephrotic syndrome. Nephron. 1995; 70::271.
    [Google Scholar]
  22. Chen Ty, Hang CC. Hemostatic molecular markers in nephrotic syndrome. Am J Hematol. 1993; 44::276.
    [Google Scholar]
  23. Niaudet P. Genetic forms of nephrotic syndrome. Pediatr Nephrol. 2004; 19::1313.
    [Google Scholar]
  24. Cosio FG, Harker C. Plasma concentration of natural anticoagulants protein C and protein S in patients with proteinuria. J Lab Clin Med. 1985; 106::218.
    [Google Scholar]
  25. Marchleidt C, Mettang T. Multifactorial genesis of enhanced platelet aggregation in patients with nephrotic syndrome. Kidney Int. 1989; 36::1119.
    [Google Scholar]
  26. Joshida N, Aoki N. Release of arachidonic acid from platelets: A key role for the potentiation ofplatelet aggregability in normal subjects as well as in those with nephrotic syndrome. Blood. 1978; 52::969.
    [Google Scholar]
  27. Majumdar A, Wheeler DC. Lipid abnormalities in renal disease. J RSoc Med. 2000; 93::178.
    [Google Scholar]
  28. Joven J, Villabona C. Abnormalities of lipoprotein metabolism in patients with the nephrotic syndrome. N Engl J Med. 1990; 323::579.
    [Google Scholar]
  29. Appel G. Lipid abnormalities in renal disease. Kidney Int. 1991;:169.
    [Google Scholar]
  30. Wheeler DC, Bernard DB. Lipid abnormalities in nephrotic syndrome: causes, consequences and treatment. Am J Kidney Dis. 1994; 23::331.
    [Google Scholar]
  31. Saland JM, Ginsberg H. Dyslipidemia in pediatric renal disease: Epidemiology, pathophysiology and clinical management. CurrOpin Pediatr. 2002; 14::197.
    [Google Scholar]
  32. Rabelink TJ, Zwaginga JJ. Thrombosis and hemostasis in renal disease. Kidney Int. 1994; 46::287.
    [Google Scholar]
  33. Cattran DC, Gerall BA. Cyclosporine in patients with steroid resistant membranous nephropathy: A randomized trial. Kidney Int. 2001; 59::1484.
    [Google Scholar]
  34. Cattran DC, Pei Y. Validation of a predictive model of idiopathic membranous nephropathy: It's clinical and research implications. Kidney Int. 1997; 51::901.
    [Google Scholar]
  35. Pei Y, Cattran DC. Predicting chronic renal insufficiency in idiopathic membranous glomerulonephritis. Kidney Int. 1992; 42::960.
    [Google Scholar]
  36. Philibert D, Cattran D. Remission of proteinuria in primary glomerulonephritis: We know the goal but do we know the price. Nat Clin Pract Nephrol. 2008; 4::550.
    [Google Scholar]
  37. Alexopoulos E, Papagianni A. Induction and longterm treatment with cyclosporine in membranous nephropathy with nephritic syndrome. Nephrol Dial Transplant. 2006; 21::3127.
    [Google Scholar]
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