1887
Volume 2011, Issue 1
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

A 31-year-old male presented with generalized new-onset tonic-clonic seizure related to severe hypocalcaemia (serum calcium 1.2 mmol/l) caused by idiopathic hypoparathyroidism (parathyroid hormone concentration 6pg;normal 15-65pg). Computerized tomographic scan showed bilateral, symmetrical, intracranial calcifications involving the basal ganglia and the cerebellum.There are few reports in clinical literature describing new-onset seizure caused by primary hypoparathyroidism in adulthood and hypoparathyroidism needs to be considered in the differential diagnosis of adult-onset seizure.

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/content/journals/10.5339/qmj.2011.1.24
2011-06-01
2019-12-05
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References

  1. Garfield N, Karaplis AC. Genetic and animals models of hypoparathyroidism. Trends Endocrionl Metab. 2001; 12::288294.
    [Google Scholar]
  2. Goswami R, Brown EM, Kochupillai N, Gupta N, Rani R, Kifor O, Chattopadhyay N. Prevalence of calcium sensing receptor autoantibodies in patients with sporadic idiopathic hypoparathyroidism. Eur J Endocrinol. 2004; 150::918.
    [Google Scholar]
  3. Maeda SS, Fortes EM, Oliveira UM, Borba VC, Lazaretti-Castro M. Hypoparathyroidism and pseudohypoparathyroidism. Arq Bras Endocrinol Metabol. 2006; 50:4:664673.
    [Google Scholar]
  4. Weinzimer AS. Endocrine aspects of the 22q 11.2 deletion syndrome. Genetic in Medicine. 2001; 3::1922.
    [Google Scholar]
  5. Tohme JF, Bilezikan JP. Hypocalcemic emergencies. Endocrinol Metab Clin North Am. 1993; 22::363375.
    [Google Scholar]
  6. Kar PS, Ogoe B, Meeking D. Di-George syndrome presen ting with hypocalcaemia in adulthood: Two case reports and a review. J Clin Pathol. 2005; 58::655657.
    [Google Scholar]
  7. Mrowka M, Knake S, Klinge H, Odin P, Rosenow F. Hypocalcemic generalized seizure as a manifestation of iatrogenic hypoparathyroidism months to years after thyroid surgery. Epileptic Disorder. 2004; 6:2:8587.
    [Google Scholar]
  8. Lehmann JB, Leidy JW Jr. A post thyroidectomy convulsion: An unusual presentation of chronic hypoparathyroidism. WVMedJ. 1994 Oct; 90:10:420421.
    [Google Scholar]
  9. Ameneiros-Lago E, Maciac-Arribi M, Fernandez-Fernandez FJ, Sesma-Sánchez P. Parkinson disease and convulsions secondary to primary hypoparathyroidism. Rev Neurol Jan. 2001; 32:2:198.
    [Google Scholar]
  10. Aleem A, Al Momen AK, Harakati MS, Hassan A, Al Fawaz I. Hypocalcemia due to hypoparathyroidism in beta-thalssemia major patients. Ann Saudi Med. 2000; 20:5-6:364366.
    [Google Scholar]
  11. Verulashvili IV, Glanti LSH, Miminoshvili DK, Maniia MN, Mdivani KS. Basal ganglia calcification: Clinical manifestations and diagnostic evaluation. Georgian Med News. 2006 Nov; 140::3943.
    [Google Scholar]
  12. Mancini F, Zangaglia R, Cristina S. Secondary cervical dystonia in iatrogenic hypoparathyroidism associated with extensive brain calcifications. Funct Neurol. 2006 Jul-Sep; 21:3:165166.
    [Google Scholar]
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  • Article Type: Case Report
Keyword(s): hypocalcaemia , hypoparathyroidism and seizure
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