1887
Volume 2010, Issue 1
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

Type 1 diabetes mellitus (1 DM) resulting from immunological damage to pancreatic islets (cells is the most common immune-mediated, endocrine metabolic disorder in children with evidence suggesting that type 1 DM is a T-cell-mediated autoimmune disease. About 5% of people with a major polyendocrine autoimmune syndrome develop type 1 DM. Autoimmune thyroid disease is the most frequent autoimmune disease with type 1 DM. An estimated 7% of children with type 1 DM develop Celiac disease within six years of diagnosis. To determine the prevalence of Celiac disease and thyroid disorders among children with type 1 DM, together with their first degree relatives, and to estimate the prevalence of DM among the first degree relatives of diabetic children, 300 type 1 DM children with 1950 first degree relatives were matched with 600 controls together with their 3,900 first degree relatives were screened in a case control study for autoimmune diseases (Celiac disease, thyroid disorders) and the first degree relatives of cases and controls were screened for type 1 DM. Celiac disease and thyroid disorders were insignificantly higher in cases than in controls. Similar findings were seen in 1 st degree relatives of cases compared to controls, with a significant difference in Celiac disease. Type 1DM prevalence was significantly higher in 1st degree relatives of cases than controls. Conclusion: Target screening for Celiac disease and thyroid diseases in type 1 DM children is necessary, but screening 1st degree relatives of diabetic children for auto-immune diseases remains controversial.

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2010-06-01
2019-10-22
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References

  1. 1. Al Emzodch   R., , Wyatt   D. . Diabetes Mellitas. . In: Behrman   E., Kliegmans   M., Jenson   B. , eds. Nelson Textbook of Pediatric . 583 . , 17th ed. . Philadelphia: : Saunders;   2004; ; : 1947– 1970 .
    [Google Scholar]
  2. 2. Chase   H., , Eisenbarth   G. . Diabetes Mellitus. . In: Hay   W., Hayward   A., Levin   M., Sandheimer   J. , eds. Current Pediatric Diagnosis and Treatment . 31 . , 16th ed.   2002; ; : 978– 980 .
    [Google Scholar]
  3. 3. White   N., , Rudoloph   A. . Rodoloph's Pediatrics . , 20th ed. . 22; 11   New York: : McGraw Hill;   1999; ; : 1805– 1893 .
    [Google Scholar]
  4. 4. Michael   M., , Frank   K., , Austen   N., , daman   E., , Auaune   R. . Smarter's immunologic diseases . 55 . , 5th ed.   1999; ; : 1007– 1009 .
    [Google Scholar]
  5. 5. Like   A., , Appel   C., , Rosisini   A. . Auto antibodies in the BB/W rat. . Diabetes . 1982; ;31: : 816– 820 .
    [Google Scholar]
  6. 6. Pickup   J., , William   G. . Textbook of Diabetes . , 2nd ed.   15.1   1997; .
    [Google Scholar]
  7. 7. Libman   M., , Petropaolo   M., , Trucco   M. , et al. , Islet cells autoimmunity in a white and black children and adolescents with Type 1 DM. . Diabetic care . 1998; ;21: : 1824 .
    [Google Scholar]
  8. 8. Palmer   P. . Insulin auto antibodies: Their role in the pathogenesis of Type 1DM. . Diabetic Metob Rev . 1987; ;3: : 1003 .
    [Google Scholar]
  9. 9. Clerrici   M., , Shaerer   G. . The hypothesis of HIV infection: New in sight. . Immunol Today . 1994; ;15: : 375– 381 .
    [Google Scholar]
  10. 10. Peros   P., , McCrimmon   R., , Shaww   G., , Frier   M. . Frequency of thyroid dysfunction in the diabetes patient: Value of annual screening. . Diabetes Med . 1995; ;12: : 622– 627 .
    [Google Scholar]
  11. 11. Becker   J., , Drash   L., , Becker   L. . Principle and practice of Endocrinology and Metabolism . 157 . , 3rd ed.   2001; ; : 1459– 1466 .
    [Google Scholar]
  12. 12. Malcova   H., , Sumnik   Z., , Drevinek   P., , Lebl   J., , Venhacova   J., , Vavrinec   J. . Type 1 diabetes mellitus and associated autoimmune disease in the first degree relatives of diabetic children. . Cas Lek Cesk . 2004; ;143: 9 : 625– 629 , (Medline) .
    [Google Scholar]
  13. 13. Hanukoglu   A., , Dalai   I., , Bistritzer   Z., , Lehmann   D., , Golander   A. . Extra pancreatic Autoimmune Manifestation in Type 1 Diabetes Patient and their First Degree relatives. . Diabetic Care . 2003; ;26: : 1235– 1240 .
    [Google Scholar]
  14. 14. Sumnik   Z. , et al. , High Prevalence of Celiac disease in siblings of children with type 1 Diabetes. . Eur J Pediat . 2005; ;164: 1 : 9– 12 .
    [Google Scholar]
  15. 15. Maki   M., , Collin   P. . Celiac disease. . Lancet . 1997; ;349: : 1755– 1759 .
    [Google Scholar]
  16. 16. Stockman   A. . Year book of Pediatrics . 2001; ; : 98– 99 .
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5339/qmj.2010.1.13
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  • Article Type: Research Article
Keyword(s): autoimmune disease , Celiac disease , Diabetes mellitus type one , Iraqi children and thyroid disease
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