1887
Volume 2010, Issue 1
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

Type 1 diabetes mellitus (1 DM) resulting from immunological damage to pancreatic islets (cells is the most common immune-mediated, endocrine metabolic disorder in children with evidence suggesting that type 1 DM is a T-cell-mediated autoimmune disease. About 5% of people with a major polyendocrine autoimmune syndrome develop type 1 DM. Autoimmune thyroid disease is the most frequent autoimmune disease with type 1 DM. An estimated 7% of children with type 1 DM develop Celiac disease within six years of diagnosis. To determine the prevalence of Celiac disease and thyroid disorders among children with type 1 DM, together with their first degree relatives, and to estimate the prevalence of DM among the first degree relatives of diabetic children, 300 type 1 DM children with 1950 first degree relatives were matched with 600 controls together with their 3,900 first degree relatives were screened in a case control study for autoimmune diseases (Celiac disease, thyroid disorders) and the first degree relatives of cases and controls were screened for type 1 DM. Celiac disease and thyroid disorders were insignificantly higher in cases than in controls. Similar findings were seen in 1 st degree relatives of cases compared to controls, with a significant difference in Celiac disease. Type 1DM prevalence was significantly higher in 1st degree relatives of cases than controls. Conclusion: Target screening for Celiac disease and thyroid diseases in type 1 DM children is necessary, but screening 1st degree relatives of diabetic children for auto-immune diseases remains controversial.

Loading

Article metrics loading...

/content/journals/10.5339/qmj.2010.1.13
2010-06-01
2019-12-08
Loading full text...

Full text loading...

References

  1. Al Emzodch R, Wyatt D. Diabetes Mellitas. In: Behrman EKliegmans MJenson B, eds. Nelson Textbook of Pediatric. 583. 17th ed. Philadelphia: Saunders 2004;:19471970.
    [Google Scholar]
  2. Chase H, Eisenbarth G. Diabetes Mellitus. In: Hay WHayward ALevin MSandheimer J, eds. Current Pediatric Diagnosis and Treatment. 31. 16th ed 2002;:978980.
    [Google Scholar]
  3. White N, Rudoloph A. Rodoloph's Pediatrics. 20th ed. 22; 11 New York: McGraw Hill 1999;:18051893.
    [Google Scholar]
  4. Michael M, Frank K, Austen N, daman E, Auaune R. Smarter's immunologic diseases. 55. 5th ed 1999;:10071009.
    [Google Scholar]
  5. Like A, Appel C, Rosisini A. Auto antibodies in the BB/W rat. Diabetes. 1982; 31::816820.
    [Google Scholar]
  6. Pickup J, William G. Textbook of Diabetes. 2nd ed 15.1 1997.
    [Google Scholar]
  7. Libman M, Petropaolo M, Trucco M, et al., Islet cells autoimmunity in a white and black children and adolescents with Type 1 DM. Diabetic care. 1998; 21::1824.
    [Google Scholar]
  8. Palmer P. Insulin auto antibodies: Their role in the pathogenesis of Type 1DM. Diabetic Metob Rev. 1987; 3::1003.
    [Google Scholar]
  9. Clerrici M, Shaerer G. The hypothesis of HIV infection: New in sight. Immunol Today. 1994; 15::375381.
    [Google Scholar]
  10. Peros P, McCrimmon R, Shaww G, Frier M. Frequency of thyroid dysfunction in the diabetes patient: Value of annual screening. Diabetes Med. 1995; 12::622627.
    [Google Scholar]
  11. Becker J, Drash L, Becker L. Principle and practice of Endocrinology and Metabolism. 157. 3rd ed 2001;:14591466.
    [Google Scholar]
  12. Malcova H, Sumnik Z, Drevinek P, Lebl J, Venhacova J, Vavrinec J. Type 1 diabetes mellitus and associated autoimmune disease in the first degree relatives of diabetic children. Cas Lek Cesk. 2004; 143:9:625629, (Medline).
    [Google Scholar]
  13. Hanukoglu A, Dalai I, Bistritzer Z, Lehmann D, Golander A. Extra pancreatic Autoimmune Manifestation in Type 1 Diabetes Patient and their First Degree relatives. Diabetic Care. 2003; 26::12351240.
    [Google Scholar]
  14. Sumnik Z, et al., High Prevalence of Celiac disease in siblings of children with type 1 Diabetes. Eur J Pediat. 2005; 164:1:912.
    [Google Scholar]
  15. Maki M, Collin P. Celiac disease. Lancet. 1997; 349::17551759.
    [Google Scholar]
  16. Stockman A. Year book of Pediatrics. 2001;:9899.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5339/qmj.2010.1.13
Loading
  • Article Type: Research Article
Keyword(s): autoimmune disease , Celiac disease , Diabetes mellitus type one , Iraqi children and thyroid disease
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error