- ISSN: 0253-8253
- EISSN: 2227-0426
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- Source: Qatar Medical Journal, Volume 2009, Issue 1, May 2009,
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- 01 May 2009
oa Success Rate of Radioiodine Treatment of Hyperthyroidism in Qatari Patients.
Abstract
To evaluate the response rate of hyperthyroidism to radioactive iodine treatment (RAI) and the mortality rate post RAI treatment in a Qatari cohort the records were analyzed retrospectively of 113 hyperthyroid Qatari patients (23 male, 90 female) treated with RAI (1-131) in the Endocrine Clinic, Hamad Medical Corporation, between 1984 and2002. 90 (79.6 %) had diffuse goiter, 14 (12.4%) multinodular goiter, 6 (5.3%) single nodular goiter and 3 (2.7 %) unknown etiology. Follow up ranged from two to ten years with free thyroxin and thyroid stimulating hormone being recorded at diagnosis; six months and one year post RAI treatment and yearly thereafter.
The incidence of hypothyroidism was 64.4% after six months post RAI treatment and 75.9% at one year. Euthyroid state was high in patients who did not receive antithyroid drugs, whereas the hypothyroid state was higher in a group with pre-treatment antithyroid medication (80% versus 62.8%). The euthyroid state was more in diffuse hyperthyroidism 22.4%, while 84.6% of multinodular goiter became hypothyroid after six months of RAI treatment. Mortality rate was not increased post RAI treatment as compared to general population.
Conclusion: The incidence of hypothyroidism was 75.9% at one-year post RAI treatment and the rate of hypothyroidism increased with the length of follow up to 10 years (86.7%). There was no linear relation in response rate to increasing doses of RAI treatment groups.
