1887
Volume 2009, Issue 1
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

To evaluate the response rate of hyperthyroidism to radioactive iodine treatment (RAI) and the mortality rate post RAI treatment in a Qatari cohort the records were analyzed retrospectively of 113 hyperthyroid Qatari patients (23 male, 90 female) treated with RAI (1-131) in the Endocrine Clinic, Hamad Medical Corporation, between 1984 and2002. 90 (79.6 %) had diffuse goiter, 14 (12.4%) multinodular goiter, 6 (5.3%) single nodular goiter and 3 (2.7 %) unknown etiology. Follow up ranged from two to ten years with free thyroxin and thyroid stimulating hormone being recorded at diagnosis; six months and one year post RAI treatment and yearly thereafter.

The incidence of hypothyroidism was 64.4% after six months post RAI treatment and 75.9% at one year. Euthyroid state was high in patients who did not receive antithyroid drugs, whereas the hypothyroid state was higher in a group with pre-treatment antithyroid medication (80% versus 62.8%). The euthyroid state was more in diffuse hyperthyroidism 22.4%, while 84.6% of multinodular goiter became hypothyroid after six months of RAI treatment. Mortality rate was not increased post RAI treatment as compared to general population.

Conclusion: The incidence of hypothyroidism was 75.9% at one-year post RAI treatment and the rate of hypothyroidism increased with the length of follow up to 10 years (86.7%). There was no linear relation in response rate to increasing doses of RAI treatment groups.

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2009-05-01
2019-10-14
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References

  1. 1. Ghadban   K., , Mahmoud   A. . Zirie, Radioiodine treatment of hyperthyroidism: success rate and influence of thyrostatic medication. . Saudi Med J . 2003; ;24: 4 : 347– 351 .
    [Google Scholar]
  2. 2. Judith E.   Kalinyak., , Rose   McDougall. . Editorial: How Should the Dose ofIodine-131 Be Determined in the Treatment of Graves’ Hyperthyroidism?.   The Journal of Clinical Endocrinology and Metabolism . 2003; ;88: 3 : 975– 977 .
    [Google Scholar]
  3. 3. William   D., , Leslie Linda   Ward. . A Randomized Comparison of Radioiodine Doses in Graves’ Hyperthyroidism. . The Journal of Clinical Endocrinology and Metabolism . 2003; ;88: 3 : 978– 983 .
    [Google Scholar]
  4. 4. Vania A.   Andrade., , Jorge L.   Gross. . The Effect of Methimazole Pretreatment on the Efficacy of Radioactive Iodine Therapy in Graves Hyperthyroidism: One- Year Follow-Up of a Prospective, Randomized Study. . The Journal of Clinical Endocrinology and Metabolism . 2001; ;86: 8 : 3488– 3493 .
    [Google Scholar]
  5. 5. Amit   Allahabadia., , Jacquie   Day kin. . Radioiodine Treatment of Hyp erthyroidism-Prognostic Factors for Outcome. . The Journal of Clinical Endocrinology and Metabolism . 2001; ;86: 8 : 3611– 3617 .
    [Google Scholar]
  6. 6. Franklyn   JA., , Maisonneuve   P. . Mortality After The Treatment of Hyperthyroidism with Radioactive Iodine. . The New England Journal of Medicine . 1998; ;338: : 712– 718 .
    [Google Scholar]
  7. 7. Lowdell   CP., , Dobbs   HJ. . Low-dose 1131 in Treatment of Graves’ Disease. . Journal of the Royal Sociaty of Medicine . 1985 March; ;78: : 197– 202 .
    [Google Scholar]
  8. 8. Sankar   R., , Sekhri   T. . Radioactive iodine therapy in Graves’ hyperthyroidism: a prospective study from a tertiary referral centre in north India. . J Assoc Physicians India . 2005 Jul; ;53: : 603– 606 .
    [Google Scholar]
  9. 9. Aftab M   Ahmad., , Munir   Ahmad. . Objective estimates of the probability of developing hypothyroidism following radioactive iodine treatment of thyrotoxicosis. . European Journal of Endocrinology . 2002; ;146: : 767– 775 .
    [Google Scholar]
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