1887
Volume 2008, Issue 1
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

In what appears to be the first case of Adult T-cell Leukemia|Lymphoma (ATLL) reported in Qatar and Middle Eastern Arab countries, a 39-year-old lady presented first with Pneumocystis carinii pneumonia and hypercalcaemia and later showed the full picture of ATLL, splenomegaly leukocytosis, skin rash, and bone marrow infiltrations. She responded well to chemotherapy, with complete remission after four cycles of combination chemotherapy but the prognosis of patients with ATLL is poor. Although patients may respond initially to treatment with combination chemotherapy regimens devised for advanced, aggressive Non-Hodgkin's Lymphoma (NHL), relapses are common with a median survival of eight months and a four-year survival of 12 percent.

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2008-06-01
2019-10-21
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References

  1. 1. Harris   NL., , Jaffe   ES., , Stein   H. . A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. . Blood . 1994; ;84: : 1361 .
    [Google Scholar]
  2. 2. Harris   NL., , Jaffe   ES., , Diebold   J. . World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, 1997. . J Clin Oncol . 1999; ;17: : 3835 .
    [Google Scholar]
  3. 3. Kikuchi   M., , Mitsui   T., , Takeshita   M. . Virus associated adult T-cell leukemia (ATL) in Japan: Clinical, histological and immunological studies. . Hematol Oncol . 1986; ;4: : 67 .
    [Google Scholar]
  4. 4. Fahim   S., , Prokopetz   R., , Jackson   R., , Faught   C., , McCarthy   AE., , Andonov   A., , Coulthart   M., , Daw   Z., , Olberg   B., , Giulivi   A., , Padmore   R. . Human T-cell lymphotropic virus Type 1-associated adult T-cell leukemia/lymphoma in the Inuit people ofNunavut. . CMAJ . September 12. doi:10.1503Icmaj.060242   2006; ;175: 6 .
    [Google Scholar]
  5. 5. Yamada   Y., , Kamihira   S., , Murata   K. . Frequent hepatic involvement in adult Tcell leukemia: Comparison with non-Hodgkin's lymphoma. . Leuk Lymphoma . 1997; ;26: : 327 .
    [Google Scholar]
  6. 6. Poiesz   BJ., , Poiesz   MJ., , Choi   D. . The human T- cell lymphoma leukemia viruses. . Cancer Invest . 2003; ;1: : 253– 277 .
    [Google Scholar]
  7. 7. Taylor   GP. . The epidemiology of HTLV-1 in Europe.. . J Acquired Immune Def Syndrome Human Retroviro . 1996; ;13: Suppl. 1 : S8– S14 .
    [Google Scholar]
  8. 8. Poiesz   BJ., , Ruscetti   FW., , Gazdar   AF., , Bunn   PA., , Minna   JD., , Gallo   RC. . Detection and isolation of Type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. . Proc Natl Acad Sci USA . 1980; ;77: : 7415– 7419 .
    [Google Scholar]
  9. 9. Reitz   MS Jr., , Poiesz   BJ., , Ruscetti   FW., , Gallo   RC. . Characterization and distribution of nucleic acid sequences of novel Type C retrovirus isolated from neoplastic human T lymphocytes. . Proc Natl Acad Sci U S A . 1981; ;78: : 1887– 1891 .
    [Google Scholar]
  10. 10. Uchiyama   T., , Yodoi   J., , Sagawa   K., , Takatsuki   K., , Uchino   H. . Adult Tcell leukemia: clinical and hematologic features of 16 cases. . Blood . 1977; ;50: : 481– 492 .
    [Google Scholar]
  11. 11. Blattner   WA., , Kalyanaraman   VS., , Robert-Guroff   M. . The human Type-C retrovirus, HTLV, in blacks from the Caribbean region, and the relationship to adult T-cell leukemia/lymphoma. . Int J Cancer . 1982; ;30: : 257– 264 .
    [Google Scholar]
  12. 12. Hinuma   Y., , Komoda   H., , Chosa   T. . Antibodies to adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: a nation-wide sero-epidemiologic study. . Int J Cancer . 1982; ;29: : 631– 635 .
    [Google Scholar]
  13. 13. Saxinger   W., , Blattner   WA., , Levine   PH. . Human T-cell leukemia virus (HTLV-1) antibodies in Africa. . Sci . 1984; ;225: : 1473– 1476 .
    [Google Scholar]
  14. 14. Meytes   D., , Schochat   B., , Lee   H. . Serological and molecular survey for HTLV-I infection in a high-risk Middle Eastern group. . Lancet . 1990; ;336: : 1533– 1535 .
    [Google Scholar]
  15. 15. Robert-Guroff   M., , Weiss   SH., , Giron   JA. . Prevalence of antibodies to HTLV-1,11, and 111 in intravenous drug abusers from an AIDS endemic region. . JAMA . 1986; ;255: : 3133– 3137 .
    [Google Scholar]
  16. 16. Tajima   K., , Ito   SI., , Tsushima   ATL. . Study Group. Prospective studies of HTLV-I and associated diseases in Japan. . In: Blattner   WA. , ed. Human retrovirology: HTLV . New York: : Raven Press;   1990; ; : 267– 279 .
    [Google Scholar]
  17. 17. Murphy   EL., , Hanchard   B., , Figueroa   JP. . Modelling the risk of adult T-cell leukemia/lymphoma in persons infected with human T-lymphotropic virus type I. . Int J Cancer . 1989; ;43: : 250 .
    [Google Scholar]
  18. 18. Shimoyama   M., , Ota   K., , Kikuchi   M. . Chemotherapeutic results and prognostic factors of patients with advanced non-Hodgkin's lymphoma treated with VEPA or VEPA-M. . J Clin Oncol . 1988; ;6: : 128– 141 .
    [Google Scholar]
  19. 19. Lymphoma Study Group . Major prognostic factors of patients with adult T-cell leukemia-lymphoma: a cooperative study. . Leuk Res . 1991; ;15: : 81– 90 .
    [Google Scholar]
  20. 20. Fawzi   ZO., , Al Malki   A., , Al Mutawa   H. . Prevalence of Human TLymphotropic Virus (HTLV) Antibodies Among the Donor Population in the State of Qatar. . In press Qatar Medical Journal .
    [Google Scholar]
  21. 21. AlMufti   S., , Voevodin   A., , Ahmed   S., , Al Hamdan   S., , Al Basheer   AA. . Seroprevalence of Human T-Cell Leukemia/Lymphoma Virus Type I and Type II (HTLV-I/HTLV-II) Infection among Volunteer Blood Donors in Kuwait. . Medical Principles and Practice . 1999; ;8: : 45– 50 .
    [Google Scholar]
  22. 22. Nicot   C. . Current views in HTLV-I-associated adult T-cell leukemia lymphoma. . Am J Hematol . 2005 Mar; ;78: 3 : 232– 239 .
    [Google Scholar]
  23. 23. Uchiyama   T., , Yodoi   J., , Sagawa   K. . Adult T-cell leukemia: Clinical and hematologic features of 16 cases. . Blood . 1977; ;50: : 481 .
    [Google Scholar]
  24. 24. Yamada   Y., , Kamihira   S., , Murata   K. . Frequent hepatic involvement in adult Tcell leukemia: comparison with non-Hodgkin's lymphoma. . Leuk Lymphoma . 1997; ;26: : 327 .
    [Google Scholar]
  25. 25. Okada   F., , Ando   Y., , Kondo   Y. . Thoracic CT findings of adult T-cell leukemia or lymphoma. . AJR Am J Roentgenol . 2004; ;182: : 761 .
    [Google Scholar]
  26. 26. Gill   PS., , Harrington   W., , Kaplan   MH., , Ribeiro   RC., , Bennett   JM. , Bernstein-Singer   M., , Espina   BM., , Cabral   L., , Allen   S., , Kornblau   S., , Pike   MC., , Levine   AM. . Treatment of Adult T-Cell Leukemia-Lymphoma with a Combination of Interferon Alfa and Zidovudine. . N Engl J Med . 1995; ;332: : 1744– 1748 .
    [Google Scholar]
  27. 27. Tobinai   K., , Kobayashi   Y., , Shimoyama   M. . The Lymphoma Study Group of the Japan Clinical Oncology Group; Pagano JS, Gill PS, Harrington W, Levine A. Interferon Alfa and Zidovudine in Adult T-Cell Leukemia-Lymphoma. . N Engl J Med . 1995; ;333: : 1285– 1286 , Nov 9, 1995 .
    [Google Scholar]
  28. 28. Shtalrid   M., , Shvidel   L., , Korenfeld   R., , Duek   A., , Landau   Z., , Berrebi   A. . HTLV-1 associated adult T-cell leukemia/lymphoma in Israel: Report of two patients of Romanian origin. . Haematologica . 2005 Mar; ;90: 3 , ECR13 .
    [Google Scholar]
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