1887
Volume 2008, Issue 1
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

In what appears to be the first case of Adult T-cell Leukemia|Lymphoma (ATLL) reported in Qatar and Middle Eastern Arab countries, a 39-year-old lady presented first with Pneumocystis carinii pneumonia and hypercalcaemia and later showed the full picture of ATLL, splenomegaly leukocytosis, skin rash, and bone marrow infiltrations. She responded well to chemotherapy, with complete remission after four cycles of combination chemotherapy but the prognosis of patients with ATLL is poor. Although patients may respond initially to treatment with combination chemotherapy regimens devised for advanced, aggressive Non-Hodgkin's Lymphoma (NHL), relapses are common with a median survival of eight months and a four-year survival of 12 percent.

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2008-06-01
2020-07-03
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References

  1. Harris NL, Jaffe ES, Stein H. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood. 1994; 84::1361.
    [Google Scholar]
  2. Harris NL, Jaffe ES, Diebold J. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee meeting-Airlie House, Virginia, 1997. J Clin Oncol. 1999; 17::3835.
    [Google Scholar]
  3. Kikuchi M, Mitsui T, Takeshita M. Virus associated adult T-cell leukemia (ATL) in Japan: Clinical, histological and immunological studies. Hematol Oncol. 1986; 4::67.
    [Google Scholar]
  4. Fahim S, Prokopetz R, Jackson R, Faught C, McCarthy AE, Andonov A, Coulthart M, Daw Z, Olberg B, Giulivi A, Padmore R. Human T-cell lymphotropic virus Type 1-associated adult T-cell leukemia/lymphoma in the Inuit people ofNunavut. CMAJ. September 12. doi:10.1503Icmaj.060242 2006; 175:6.
    [Google Scholar]
  5. Yamada Y, Kamihira S, Murata K. Frequent hepatic involvement in adult Tcell leukemia: Comparison with non-Hodgkin's lymphoma. Leuk Lymphoma. 1997; 26::327.
    [Google Scholar]
  6. Poiesz BJ, Poiesz MJ, Choi D. The human T- cell lymphoma leukemia viruses. Cancer Invest. 2003; 1::253277.
    [Google Scholar]
  7. Taylor GP. The epidemiology of HTLV-1 in Europe.. J Acquired Immune Def Syndrome Human Retroviro. 1996; 13:Suppl. 1:S8S14.
    [Google Scholar]
  8. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of Type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA. 1980; 77::74157419.
    [Google Scholar]
  9. Reitz MS Jr, Poiesz BJ, Ruscetti FW, Gallo RC. Characterization and distribution of nucleic acid sequences of novel Type C retrovirus isolated from neoplastic human T lymphocytes. Proc Natl Acad Sci U S A. 1981; 78::18871891.
    [Google Scholar]
  10. Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H. Adult Tcell leukemia: clinical and hematologic features of 16 cases. Blood. 1977; 50::481492.
    [Google Scholar]
  11. Blattner WA, Kalyanaraman VS, Robert-Guroff M. The human Type-C retrovirus, HTLV, in blacks from the Caribbean region, and the relationship to adult T-cell leukemia/lymphoma. Int J Cancer. 1982; 30::257264.
    [Google Scholar]
  12. Hinuma Y, Komoda H, Chosa T. Antibodies to adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: a nation-wide sero-epidemiologic study. Int J Cancer. 1982; 29::631635.
    [Google Scholar]
  13. Saxinger W, Blattner WA, Levine PH. Human T-cell leukemia virus (HTLV-1) antibodies in Africa. Sci. 1984; 225::14731476.
    [Google Scholar]
  14. Meytes D, Schochat B, Lee H. Serological and molecular survey for HTLV-I infection in a high-risk Middle Eastern group. Lancet. 1990; 336::15331535.
    [Google Scholar]
  15. Robert-Guroff M, Weiss SH, Giron JA. Prevalence of antibodies to HTLV-1,11, and 111 in intravenous drug abusers from an AIDS endemic region. JAMA. 1986; 255::31333137.
    [Google Scholar]
  16. Tajima K, Ito SI, Tsushima ATL. Study Group. Prospective studies of HTLV-I and associated diseases in Japan. In: Blattner WA, ed. Human retrovirology: HTLV. New York: Raven Press 1990;:267279.
    [Google Scholar]
  17. Murphy EL, Hanchard B, Figueroa JP. Modelling the risk of adult T-cell leukemia/lymphoma in persons infected with human T-lymphotropic virus type I. Int J Cancer. 1989; 43::250.
    [Google Scholar]
  18. Shimoyama M, Ota K, Kikuchi M. Chemotherapeutic results and prognostic factors of patients with advanced non-Hodgkin's lymphoma treated with VEPA or VEPA-M. J Clin Oncol. 1988; 6::128141.
    [Google Scholar]
  19. Lymphoma Study Group. Major prognostic factors of patients with adult T-cell leukemia-lymphoma: a cooperative study. Leuk Res. 1991; 15::8190.
    [Google Scholar]
  20. Fawzi ZO, Al Malki A, Al Mutawa H. Prevalence of Human TLymphotropic Virus (HTLV) Antibodies Among the Donor Population in the State of Qatar. In press Qatar Medical Journal.
    [Google Scholar]
  21. AlMufti S, Voevodin A, Ahmed S, Al Hamdan S, Al Basheer AA. Seroprevalence of Human T-Cell Leukemia/Lymphoma Virus Type I and Type II (HTLV-I/HTLV-II) Infection among Volunteer Blood Donors in Kuwait. Medical Principles and Practice. 1999; 8::4550.
    [Google Scholar]
  22. Nicot C. Current views in HTLV-I-associated adult T-cell leukemia lymphoma. Am J Hematol. 2005 Mar; 78:3:232239.
    [Google Scholar]
  23. Uchiyama T, Yodoi J, Sagawa K. Adult T-cell leukemia: Clinical and hematologic features of 16 cases. Blood. 1977; 50::481.
    [Google Scholar]
  24. Yamada Y, Kamihira S, Murata K. Frequent hepatic involvement in adult Tcell leukemia: comparison with non-Hodgkin's lymphoma. Leuk Lymphoma. 1997; 26::327.
    [Google Scholar]
  25. Okada F, Ando Y, Kondo Y. Thoracic CT findings of adult T-cell leukemia or lymphoma. AJR Am J Roentgenol. 2004; 182::761.
    [Google Scholar]
  26. Gill PS, Harrington W, Kaplan MH, Ribeiro RC, Bennett JM, Bernstein-Singer M, Espina BM, Cabral L, Allen S, Kornblau S, Pike MC, Levine AM. Treatment of Adult T-Cell Leukemia-Lymphoma with a Combination of Interferon Alfa and Zidovudine. N Engl J Med. 1995; 332::17441748.
    [Google Scholar]
  27. Tobinai K, Kobayashi Y, Shimoyama M. The Lymphoma Study Group of the Japan Clinical Oncology Group; Pagano JS, Gill PS, Harrington W, Levine A. Interferon Alfa and Zidovudine in Adult T-Cell Leukemia-Lymphoma. N Engl J Med. 1995; 333::12851286, Nov 9, 1995.
    [Google Scholar]
  28. Shtalrid M, Shvidel L, Korenfeld R, Duek A, Landau Z, Berrebi A. HTLV-1 associated adult T-cell leukemia/lymphoma in Israel: Report of two patients of Romanian origin. Haematologica. 2005 Mar; 90:3, ECR13.
    [Google Scholar]
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