1887
Volume 2007, Issue 2
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

Xanthomas are localized infiltrates oftipid-containing cells found within the dermis. Cutaneous xanthomas are mostly cosmetic disorders but xanthomas can indicate the presence of an underlying generalized disturbance in lipid metabolism possibly associated with coronary artery disease. Because hyperlipidemia may present as xanthomatosis, a dermatologist might be the first to diagnose these associated lipid abnormalities, We report a 36-year-old male who presented with four classic types of xanthomas (Xanthelasma, Tuberous, Eruptive and Plane xanthomas) at the same time. Laboratory tests confirmed hypercholesterolemia and hypertriglyceridemia of dysbetalipoprotein Type III of the Fredrickson classification. The occurrence of four clinical types of xanthomas simultaneously in the same patient is rarely reported in the literature. The clinical, histopathology, laboratory investigation and management of hyperlipidemia and cutaneous lesions is fully discussed together with a review of the literature.

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2007-11-01
2019-10-14
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References

  1. 1. Rader   DJ. . Pathophysiology and management of low density lipoprotein cholesterol. . Am J Card . 1999; ;13: : 83 .
    [Google Scholar]
  2. 2. Parker   F. . Xanthomas and hyperlipidemias. . J AM Acad Dermatol . 1985; ;13: : 1– 30 .
    [Google Scholar]
  3. 3. Teltscher   J., , Silverman   RA., , Stork   J. . Eruptive xanthomas in a child with the nephrotic syndrome. . J AM Acad Dermatol.   1989; ;21: : 1147– 1149 .
    [Google Scholar]
  4. 4. Jennifer   RS., , Jasonlee., , Sylvia   H. . Multiple umbilicated papules on a young man. . Arch Dermatol.   2001; ;137: : 85– 89 .
    [Google Scholar]
  5. 5. Dicken   C., , Connolly   S. . Eruptive xanthomas associated with isotretinoin. . Arch Dermatol.   1980; ;116: : 951– 952 .
    [Google Scholar]
  6. 6. Franik   P. . Normocholesterolemic xanthomatosis. . Arch Dermatol.   1986; ;122: : 1253– 1257 .
    [Google Scholar]
  7. 7. Polano   MK. . Xanthomatosis and hyperlipoproteinemia. . Dermatologica.   1974; ;149: : 1– 9 .
    [Google Scholar]
  8. 8. Vermeer   BJ., , Gevers   L. . New aspects of xanthomatosis and hyperlipoproteinemia. . Curr Probl Dermatol.   1991; ;20: : 63– 72 .
    [Google Scholar]
  9. 9. Marcelo   G. . Xanthomas. . eMedicine . 2002; ;2: : 1– 9 .
    [Google Scholar]
  10. 10. Cruz   PD., , East   C. . Dermal, Subcutaneous and tendon xanthomas: Diagnostic markers of specific lipoprotein disorders. . J AM Acad Dermatol.   1988; ;19: : 95– 111 .
    [Google Scholar]
  11. 11. Gotto   AM. . Clinical diagnosis of hyperlipoproteinemia. . AM J Med.   1983; ;74: : 5– 9 .
    [Google Scholar]
  12. 12. Lover   JR., , Dubin   HV. . Xanthomas and lipoproteins. . Cutis . 1978; ;21: : 801– 805 .
    [Google Scholar]
  13. 13. Caputo   R., , Monti   M., , Berti   E. . Normolipemic eruptive cutaneous Xanthomatosis. . Arch Dermatol.   1986; ;122: : 1294– 1297 .
    [Google Scholar]
  14. 14. Janis   P. . Xanthomas, eMedicine. . 2002; ;2: : 5– 7 .
    [Google Scholar]
  15. 15. Fuiton   JE. . Dermabrasion, Chemabrasion and Laser abrasion. . Dermatol Surg.   1996; ;22: : 619– 628 .
    [Google Scholar]
  16. 16. Carpo   BG., , Grevelink   SV. . Treatment of cutaneous lesions of xanthoma disseminatum with Co2 laser. . Dermatol Surg.   1999; ;25: : 751– 754 .
    [Google Scholar]
  17. 17. Susanne   L., , Silvia   H., , Ulrich   H. . Treatment of diffuse plane xanthoma of the face with the Erbium YAG laser. . Arch Dermatol.   2001; ;137: : 1413– 1415 .
    [Google Scholar]
  18. 18. Basar   E., , Oguz   H., , Ozdemir   H. . Treatment of xanthelasma palpebrarum with argon laser photocoagulation, Argon Laser and xanthelasma palpebrarum. . Int Ophthalmol . 2004 J; ;25: 1 : 9– 11 .
    [Google Scholar]
  19. 19. Harlan   WR. . A practical approach to lowing plasma lipids. . Gen practitioner.   1999; ;29: : 101– 111 .
    [Google Scholar]
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