1887
Volume 2007, Issue 2
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

Lipid-lowering agents such as HMG-CoA reductase inhibitors (also known as statin drugs) are generally well tolerated. But a recognized side effect still can happen, We report a case of 47-year-old Iraqi male patient previously known hypothyroid, was not on replacement therapy, as he did not appear after his thyroid functions was checked came in with severe body pain for 10 months got worse in the last three months, started on lipostat (ten months ago) found to have myopathy as evident by high CPK which improved gradually clinically and biochemical after stopping lipostat.

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2007-11-01
2019-08-18
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References

  1. 1. Farmer   JA. . Learning from the cerivastatin experience (commentary). . Lancet . 2001; ;358: : 13835 .
    [Google Scholar]
  2. 2. Grundy   SM. . Can statins cause chronic low-grade myopathy ?.   Ann Intern Med . 2002; ;137: : 617 .
    [Google Scholar]
  3. 3. Grundy   SM. . HMG CO A reductase inhibitor for treatment of hypercholestrelimia. . N Engl J Med . l998 Jul 7; ;319: 1 : 24– 33 .
    [Google Scholar]
  4. 4. Hansen   KE., , Hildebrand   JP., , Furguson   EE. . JH Outcomes in 45 patients with statin-associated myopathy. . Arch Intern Med.   2005 Dec 12-26; ;165: 22 : 2671– 2676 .
    [Google Scholar]
  5. 5. Tobert   JA. . Efficacy and long-term adverse effect pattern of lovastatin. . Am J Cardiol . 1988 Nov 11; ;62: 15 : 28J– 34J .
    [Google Scholar]
  6. 6. The Pink Sheet” FDC Reports. 2002; 64 (Vol 23): 5 .
  7. 7. Pfeffer   MA., , Keech   A., , Sacks   FM., , Cobbe   SM., , Tonkin   A., , Byington   RP., , Davis   BR., , Friedman   CP., , Braunwald   E. . Safety and tolerability of pravastatin in long-term clinical trials: Prospective Pravastatin Pooling (PPP) Project. . Circulation . 2002 May 21; ;105: 20 : 2341– 2346 .
    [Google Scholar]
  8. 8. Gadbut   AP., , Caruso   AP., , Galper   JB. . Differential sensitivity of C2-C12 striated muscle cells to lovastatin and pravastatin. . J Mol Cell Cardiol . 1995 Oct; ;27: 10 : 2397– 2402 .
    [Google Scholar]
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  • Article Type: Case Report
Keyword(s): myopathy and pravastatin
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