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oa A Novel Syndrome Complicating Sickle Cell Disease: Generalized Bone Marrow Necrosis
- Source: Qatar Medical Journal, Volume 2007, Issue 2, Nov 2007, 18
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- 01 November 2007
Abstract
Three adults with sickle cell disease (SCD) presented in the span of less than two years with pancytopenia, signs of Disseminated Intravascular Coagulation (DIC) and no localizing pain to suggest vaso-occlusive crisis (VOC). Bone marrow examination showed almost complete necrosis of the whole series of marrow cells, thus explaining the pancytopenia. Some necrotic leukocytes were noted also in the peripheral blood. The condition was self-limiting with marrow regeneration occurring in all three patients after transfusions of red cells and platelets.
© 2007 Al Hilali, Abdel Razeq, licensee Bloomsbury Qatar Foundation Journals.