1887
Volume 2005, Issue 2
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

A 17 year old Qatari female of Arab descent with cysticfibrosis (CF) carrying pathogenic mutation I1234V had severe respiratory disease associated with chronic Pseudomonas aeruginosa broncho-pulmonary infection with recurrent episodes of mild hemoptysis. Despite regular courses of intravenous anti-pseudomonal antibiotics, she continued to deteriorate over six months and died. It is suggested that the presence of Stenotrophomonas maltophilia was an important factor in this casey which illustrates the need for continuing vigilance in considering the acquisition of resistant organisms in such patients on long-term antibiotic therapy.

Loading

Article metrics loading...

/content/journals/10.5339/qmj.2005.2.19
2005-11-01
2024-04-16
Loading full text...

Full text loading...

References

  1. Guwitz D, Corey M, Francis PWJ, Crozier D, Levson H. Perspectives in cystic fibrosis. Pediatr Clin North Am. 1979; 26::603615.
    [Google Scholar]
  2. Davis PB, Drumm M, Konstan M. Cystic fibrosis. Am J Respir Crit Care Med. 1996; 154::12291256.
    [Google Scholar]
  3. Kulczycki LL, Murphy TM, Bellanti JA. Pseudomonas colonization in cystic fibrosis. JAMA. 1978; 240::3034.
    [Google Scholar]
  4. Less CM, Smyth RL. The current management of cystic fibrosis. Int J Clin Pract. 2000; 54::171179.
    [Google Scholar]
  5. Denton M. Stenotrophomonas maltophilia: An emerging problem in cystic fibrosis patients. Rev Med Microbiol. 1997; 8::1519.
    [Google Scholar]
  6. Blessing J, Walker J, Maybury B, Yeager AS, Lewiston N. Pseudomonas cepacia and Pseudomonas maltophilia in the cystic fibrosis patients. Am Rev Respir Dis. 1979; 119::262.
    [Google Scholar]
  7. Morrison AJ, Hoffmann KK, Wenzel RP. Associated mortality and clinical characteristics of nosocomial Pseudomonas maltophilia in a university hospital. J Clin Microbiol. 1986; 24::5255.
    [Google Scholar]
  8. Marshal WF, Keating MR, Anhalt JP, Stechelberg JM. Xanthomonas maltophilia an emerging nosocomial pathogen. Mayo Clin Proc. 1989; 64::10971104.
    [Google Scholar]
  9. Karpati F, Malmborg AS, Alfredsson H, Hjelte L, Strandvik B. Bacterial colonization with Xanthomonas maltophilia - A retrospective study in cystic fibrosis patient population. Infection. 1994; 22::258263.
    [Google Scholar]
  10. Demko CA, Stern RC, Doershuk CF. Stenotrophomonas maltophilia in cystic fibrosis: incidence and prevalence. Pediatr. Pulmonol. 1998; 25::304308.
    [Google Scholar]
  11. Ballestero S, Virseda I, Escobar H, Suarez L, Baquero F. Stenotrophomonas maltophilia in cystic fibrosis. Eur J Clin Microbiol Infect Dis. 1995; 14::728729.
    [Google Scholar]
  12. Talmaciu I, Varlotta L, Mortensen J, Schidlow DV. Risk factors for emergence of Stenotrophomonas maltophilia in cystic fibrosis. Pediatr. Pulmonol. 2000; 30::1015.
    [Google Scholar]
  13. Vartivarian S, Anaissie E, Bodey G, Sprigg H, Rolston K. A changing pattern of susceptibility of Xanthomonas maltophilia to antimicrobilial agents: impliction for therapy. Antimicrob Agents Chemother. 1994; 38::624627.
    [Google Scholar]
  14. Quinn JP. Clinical Problems Posed by Mutiresistant Nonfermenting Gram-Negative Pathogens. CID. 1998; 27:Suppl 1.
    [Google Scholar]
  15. Abdul Wahab A, Al Thani G, Dawod ST, Kambouris M, Al Hamed M. Heterogeneity of the cystic fibrosis phenotype in a large kindred family in Qatar with cystic fibrosis mutation 11234V. J Trop Pediat. 2001; 47::110112.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5339/qmj.2005.2.19
Loading
  • Article Type: Case Report
Keyword(s): CFChronic Pseudomonas Aeruginosa and Stenotrophomonas Maltophilia
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error