1887
Volume 2005, Issue 1
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

Context: There is a paucity of effective, well-tolerated drugs available for migraine prophylaxis.

Objective: To determine whether treatment with the angiotensin II receptor blocker candesartan is effective as a migraine-prophylactic drug.

Design and Setting: Randomized, double-blind, placebo-controlled crossover study performed in a Norwegian neurological outpatient clinic from January 2001 to February 2002.

Patient: Sixty patients aged 18 to 65 years with 2 to 6 migraine attacks per month were recruited mainly from newspaper advertisements.

Interventions: A placebo run-in period of 4 weeks was followed by two 12-week treatment periods separated by 4 weeks of placebo washout. Thirty patients were randomly assigned to receive one 16-mg candesartan cilexetil tablet daily in the first treatment period followed by 1 placebo tablet daily in the second period. The remaining 30 received placebo followed by candesartan.

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/content/journals/10.5339/qmj.2005.1.24
2005-06-01
2019-10-18
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  • Article Type: Abstract
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