1887
Volume 2004, Issue 1
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

The benefits of cholesterol-lowering with statins has been established for patients with high cholesterol levels as well as for patients with prior occlusive coronary heart disease. However; substantial uncertainty has existed about the long-term benefits of these agents in certain groups, including patients with “normal” cholesterol levels pretreatment, women, the elderly, as well as those with prior occlusive non-coronary disease. The Heart Protection Study 1 was designed to resolve these uncertainties and to provide substantially more safety information of statins. We present its significance and practical implications.

Loading

Article metrics loading...

/content/journals/10.5339/qmj.2004.1.6
2004-06-01
2019-08-24
Loading full text...

Full text loading...

References

  1. 1. Heart Protection Collaborative Study Group . MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 individuals: A randomised placebo-controlled trial. . Lancet . 2002; ;360: : 7– 22 .
    [Google Scholar]
  2. 2. Scandinavian Simvastatin Survival Study Group . Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). . Lancet . 1994; ;344: : 1383– 1389 .
    [Google Scholar]
  3. 3. Shepherd   J., , Cobbe   SM., , Ford   I. , et al. , Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. . N Engl J Med . 1995; ;333: : 1301– 1307 .
    [Google Scholar]
  4. 4. Sacks   FM., , Pfejfer   MA., , Moye   LA. , et al. , The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators. . N Engl J Med . 1996; ;335: : 1001– 1009 .
    [Google Scholar]
  5. 5. Downs   JR., , Clearfield   M., , Weis   S. , et al. , Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. . JAMA . 1998; ;279: : 1615– 1622 .
    [Google Scholar]
  6. 6. The Long-Term Intervention With Pravastatin In Ischemic Disease (LIPID) study group . Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. . N Engl J Med . 1998; ;339: : 1349– 1357 .
    [Google Scholar]
  7. 7. Salam   AM. . Expanding indications of statins; implications of the Heart Protection Study. . Expert Opin Investig Drugs . 2003; ;12: : 509– 513 .
    [Google Scholar]
  8. 8.   Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final report. . Circulation . 2002; ;106: 25 : 3143– 3421 .
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5339/qmj.2004.1.6
Loading
  • Article Type: Review Article
Keyword(s): and tutorials , cholesterol , Coronary disease , lipid lowering and statins
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error