Volume 2003, Issue 2
  • ISSN: 0253-8253
  • EISSN: 2227-0426


We report the diagnosis of Systemic Lupus Erythematosus (SLE) in an Omani lady with consistently negative antinuclear antibody (ANA) results and an anti double stranded DNA (dsDNA) titre of 1:640. The presence of a negative ANA with a high titre of dsDNA is very unusual in SLE


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  1. Pisetsky DS, Gilkeson G, Clair EW. Systemic lupus erythematosus. Diagnosis and treatment. Med Clin North Am. 1997; 81::113128.
    [Google Scholar]
  2. Worrall J, Snaith ML, Batchelor R, Isenherg DA. SLE – A rhumatological view. Quart J Med. 1990; 275::319330.
    [Google Scholar]
  3. Ismail AA, Snowden N. Autoantibodies and specific serum proteins in the diagnosis of rheumatological disorders. Ann Clin Biochem. 1999; 36::565578.
    [Google Scholar]
  4. Koshak E, Mughales J. How the serological correlation between ANA and ds-DNA enhance cost effectiveness. Annals Saudi Med. 2000; 20::467470.
    [Google Scholar]
  5. Bohan A. Seronegative systemic lupus erythe-matosus. J Rheumatol. 1979; 6::535540.
    [Google Scholar]
  6. McHardy KC, Home CH, Rennie J. Antinuclear antibody negative systemic lupus erythematosus: How common? J Clin Pathol. 1982; 35::11181121.
    [Google Scholar]
  7. Locham KK, Singh J, Garg R, Singh M, Jain C. ANA negative lupus erythematosus. Indian Pediatr. 2000; 37::540542.
    [Google Scholar]
  8. Emlen W, Pisetsky DS, Taylor RP. Antibodies to DNA. A perspective. Arthritis Rheum. 1986; 29::14171426.
    [Google Scholar]
  • Article Type: Case Report
Keyword(s): ANAdsDNA and SLE
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