Volume 2000, Issue 2
  • ISSN: 0253-8253
  • EISSN: 2227-0426


Hypolalemic periodic paralysis is an uncommon complication of thyrotoxicosis. It usually affects men of Oriental origin and presents with acute and profound muscle weakness especially of the lower extremities. We report a 46 year old man from Kuwait with sudden paralysis of both legs. Physical examination showed signs of thyrotoxicosis and laboratory tests revealed severe hypokalemia, very low serum thyroid-stimulating hormone and very high free thyroxin. The motor deficit regressed within 8 hours of 80 mmol ofKCI infusion. Awareness of such a problem is essential to avoid life threatening cardiac arrhythmia. Once recognized the treatment is simple and the prognosis is excellent.


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  1. Stedwell RE, Allen AM, Binder LS. Hypokalemic Paralyses: A review of the etiologies, pathophysiology, presentation and therapy Am. J. Emerg. Med. 1992; 10::143148.
    [Google Scholar]
  2. Miller JD, Quillan W, Cleveland W. Nonfamilial Hypokalemic Periodic Paralysis and Thyrotoxicosis in a 16-year-old male. Pediatrics. 1997; 100::412414.
    [Google Scholar]
  3. Kelley DE, Gharib H, Kennedy F, Duda R, McManis M. Thyrotoxic Periodic Paralysis. Arch. Intern. Med. 1989; 149::25972600.
    [Google Scholar]
  4. Ko GT, Chow CC, Yeung VT, Chan JK, Cockram CS. Thyrotoxic Periodic Paralysis in the Chinese Population. Q.J. Med. 1996; 89::463468.
    [Google Scholar]
  5. Davison ET, Davison MJ. Tri-iodothyronine Toxicosis with Hypokalemic Periodic Paralysis and Ventricular Tachycardia. J. Electrocardiography. 1995; 28:2:161163.
    [Google Scholar]
  6. Ober KP. Thyrotoxic Periodic Paralysis in the United States. Medicine. 1992; 71:3:109120.
    [Google Scholar]
  7. Van Dam GM, Resiman Y, vn Wieringen K. Hypokalemic thyrotoxic periodic paralysis: case report and review of an Oriental syndrome. Netherlands J. Med. 1996; 49:2:9097.
    [Google Scholar]
  8. Mc Fadzean AJ, Yeung R. Periodic Paralysis Complicating Thyrotoxicosis in Chinese. Br. Med J. 1967; 1::451455.
    [Google Scholar]
  9. Szeto CC, Chow CC, Li KY, Ko TC, Yuoug VT. Thyrotoxicosis and renal tubular acidosis presenting as hypokalemic paralysis. Br. J. Rheumatology. 1996; 35::289291.
    [Google Scholar]
  • Article Type: Case Report
Keyword(s): Hypokalemia-Periodic Paralysis and Thyrotoxicosis-Thyroxin
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