1887
Volume 2000, Issue 2
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

Between November 1998 and May 1999 a prospective study for HCV antibodies was conducted on 200 patients (113 males and 87 females), with B-thalassemia major and sickle cell-thalassemia, who were attending the thalassemia center at Basrah Maternity and Children Hospital. Their ages ranged from 1-18 years with a mean age of 9 years.

Nineteen patients (9.5%) were found to have antibodies in comparison to only one (0.5%) amongst the 200 children of a control group. The risk of exposure to HCV was higher than for HBs antigen and HIV amongst the same patients.

Anti-HCV seropositivity was significantly higher amongst patients with B-thalassemia major than patients with sickle cell-thalassemia and patients older than 10 years.

The study showed also that anti-HCV seropositivity was directly related to the frequency of blood transfusion and there were significant elevations of serum bilirubin and aminotransferase levels amongst seropositive thalassemic patients compared to seronegative patients.

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2000-12-01
2019-10-17
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References

  1. [1]. Kuo   G., , Choo   QL., , Alter   HJ. , et al. , Assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. . Science . 1989; ;244: : 362– 364 .
    [Google Scholar]
  2. [2]. Flynn   PM. . Hepatitis C infections. . Pediatric Annals. Sept.   1996; ;25: 9 : 496– 500 .
    [Google Scholar]
  3. [3]. Alter   HJ., , Pure ell   RH., , Shin   JW. , et al. , Detection of antibody to HCV in prospectively followed transfusion recipients with acute and chronic non-A, non -B hepatitis. . N Eng J med . 1989; ;321: 22 : 1494– 1500 .
    [Google Scholar]
  4. [4]. Daris   GL., , Lim   H. . Current status of interferon therapy for chronic hepatitis C. A hepatologists prospective. . Infectious agents and disease . 1993; ;2: 3 : 150– 154 .
    [Google Scholar]
  5. [5]. Lai   ME., , Mazzoleni   AP., , Francesa   A. , et al. , Hepatitic C virus in multiple episodes of acute hepatitis in polytransjused thalassemic children. . Lancet . 1994; ;393: 12 : 388– 390 .
    [Google Scholar]
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