Volume 2000, Issue 2
  • ISSN: 0253-8253
  • EISSN: 2227-0426


Between November 1998 and May 1999 a prospective study for HCV antibodies was conducted on 200 patients (113 males and 87 females), with B-thalassemia major and sickle cell-thalassemia, who were attending the thalassemia center at Basrah Maternity and Children Hospital. Their ages ranged from 1-18 years with a mean age of 9 years.

Nineteen patients (9.5%) were found to have antibodies in comparison to only one (0.5%) amongst the 200 children of a control group. The risk of exposure to HCV was higher than for HBs antigen and HIV amongst the same patients.

Anti-HCV seropositivity was significantly higher amongst patients with B-thalassemia major than patients with sickle cell-thalassemia and patients older than 10 years.

The study showed also that anti-HCV seropositivity was directly related to the frequency of blood transfusion and there were significant elevations of serum bilirubin and aminotransferase levels amongst seropositive thalassemic patients compared to seronegative patients.


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  1. Kuo G, Choo QL, Alter HJ, et al., Assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 1989; 244::362364.
    [Google Scholar]
  2. Flynn PM. Hepatitis C infections. Pediatric Annals. Sept. 1996; 25:9:496500.
    [Google Scholar]
  3. Alter HJ, Pure ell RH, Shin JW, et al., Detection of antibody to HCV in prospectively followed transfusion recipients with acute and chronic non-A, non -B hepatitis. N Eng J med. 1989; 321:22:14941500.
    [Google Scholar]
  4. Daris GL, Lim H. Current status of interferon therapy for chronic hepatitis C. A hepatologists prospective. Infectious agents and disease. 1993; 2:3:150154.
    [Google Scholar]
  5. Lai ME, Mazzoleni AP, Francesa A, et al., Hepatitic C virus in multiple episodes of acute hepatitis in polytransjused thalassemic children. Lancet. 1994; 393:12:388390.
    [Google Scholar]
  • Article Type: Research Article
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