1887
Volume 1998, Issue 2
  • ISSN: 0253-8253
  • E-ISSN: 2227-0426

Abstract

Abstract

The purpose of this study was to validate Pugh's modification of the Child-Turcotte Classification (CTC) in the prediction of mortality in patients with liver cirrhosis.

A cohort of 45 cirrhotics collected in Mosul Teaching Hospitals, Iraq, was followed for five years and deaths were recorded at twelve month intervals from the individual dates of diagnosis. Cohort analysis and estimation of Relative Risk measured the strength of the association between Pugh's classes and five year mortality. Life table analysis was used to compute the probability of survival or death in each year during the 5 year period.

Results . During the five-year period of study twenty patients died. Eighteen of the total deaths (90%) occurred in class C (severe class) from which 78% of the patients died while only two (15% of the group) died in class B (Relative Risk = 5.2). None died in class A (mild class).

In the first year 20% of the cohort died (all from Class C) and the Life Table Analysis showed a high probability of death for the whole cohort. A further 24% died during the next four years..

Conclusion - Pugh's grading can confidently be used in clinical practice to categorize the chances of patient survival. Patients with cirrhosis in the severe grade have a poor chance of survival.

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2019-10-15
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References

  1. 1. Pugh  R.N.,, Murray-Lyon  I.M.,, Dawson  J.L., et al. Transection of the oesophagus for bleeding oesophageal varices. . Brit J Surg. 60::1973:646–649.
    [Google Scholar]
  2. 2. Murray-Lyon  I.M..,, Pugh  R.N.H..,, Nunnerley  H.B... Treatment of bleeding oesophageal varices by infusion of vasopressin into the superior mesenteric artery. . Gut 14::1973:59–63.
    [Google Scholar]
  3. 3. Christensen  E.,, Schlichting  P.,, Fauerholdt  L., et al. Prognostic value of Child-Turcotte criteria in medically treated cirrhosis. . Hepatology 4::1984:430–435.
    [Google Scholar]
  4. 4. Gines  P.,, Quintero  E.,, Arroyo  V., et al. Natural history and prognostic factors. . Hepatology 1::1987:122–128.
    [Google Scholar]
  5. 5. Infante-Rivard  C.,, Esnaola  S.,, Villeneve  J.P. et al. Clinical and statistical validity of conventional prognostic factors in predicting short term survival among cirrhotics. . Hepatology 1::1987:660–664.
    [Google Scholar]
  6. 6. Hill  A.B.. Principles of medical statistics. London. , The Lancet 1971:220–236.
    [Google Scholar]
  7. 7. Piai  G.,, Cipolletta  L.,, Claar  M., et al. Prophylactic sclerotherapy of high risk oesophageal varices: Result of a multicentric prospective controlled trial. . Hepatology 8::1988:1445–1500.
    [Google Scholar]
  8. 8. Arroyo  V.,, Bosch  J.,, Gaya-Beltran  J., et al. Plasma renin activity and urinary sodium excretion as prognostic indicators in nonazotemic cirrhosis with ascites. . Ann Intern Med 94::1981:198–201.
    [Google Scholar]
  9. 9. Vine  I.J.P.,, Gassigneul  J.,, Levade  M., et al. Assesment of short-term prognosis after variceal bleeding in patients with alcoholic cirrhosis by early measurement of portohepatic gradient. . Hepatology 6::1986:116–117.
    [Google Scholar]
  10. 10. .  .. The Copenhagen study group of liver diseases A double blind study. . Hepatology 6::1986:807–813.
    [Google Scholar]
  11. 11. Gluud  C.,, Henriksen  J.H.,, Nielsen  G., et al. Prognostic indicators in alcoholic cirrhotic men. . Hepatology 8::1988:222–227.
    [Google Scholar]
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  • Article Type: Other
Keyword(s): Life-Table , Liver Cirrhosis and Pugh's modification
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