oa Is aspirin a useful adjuvant to oral hypoglycemic agents?

Aspirin was prescribed for 20 non-insulin dependent diabetic patients receiving one of the sulfonylureas (Glibenclamide, Gliclazide and Glipizide) with or without Metformin. The majority of the patients were on Glibenclamide and Metformin.

Aspirin slows the progression of nephropathy and retinopathy. Fasting blood sugar levels improvedfollowing the addition of aspirin to oral hypoglycemic agents (OHA) (p = 0.0057). The mean fall in F.B.S. was 3.9 mmol/L.

Glycated Hemoglobin (Hb A1C) was measured before and 3 months after giving aspirin to diabetic patients receiving one of the sulfonylurea drugs with or without Metformin. Following aspirin use the Hb A1C fell significantly (p = 0.0138). The mean fall in HbAlC was 0.81%.