1887
2 - Unified National Conference of Iraqi Dental Colleges (UNCIDC)
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

Radiation-induced oral mucositis (RIOM) poses a significant challenge in the management of head and neck cancer patients (HNCs). Patients may require adjustments in their cancer treatment, such as dose reductions or treatment delays, which can decrease the effectiveness of the antineoplastic therapy. Numerous clinical investigations have demonstrated that curcumin, an herbal agent, exhibits a wide range of pharmacologic actions, including anti-inflammatory, antibacterial, and anticarcinogenic effects and the ability to enhance wound healing.

To evaluate the effect of curcumin oral gel with the magic solution (dexamethasone-based mouthwash) as a standard mouthwash treatment for RIOM in relation to salivary epidermal growth factor (EGF) before and after radiation therapy.

Thirty-one HNCs who received radiotherapy with a head and neck mask were divided into the curcumin oral gel and the magic-solution groups. Saliva samples were collected before radiation, at the 3rd week of radiation, and post-radiation. Salivary EGF was measured using an enzyme-linked immunosorbent assay. RIOM was assessed using both the WHO and the VAS scales.

Significant differences were found between both groups in the WHO scale (P = 0.027) and VAS score (P = 0.047). Patients who used oral curcumin gel presented with less severe RIOM and elevated salivary EGF levels during the radiation sessions.

Curcumin oral gel might be an effective agent in preventing and managing RIOM, as evidenced by the observed increase in salivary EGF.

Loading

Article metrics loading...

/content/journals/10.5339/jemtac.2024.uncidc.4
2024-02-07
2024-02-28
Loading full text...

Full text loading...

/deliver/fulltext/jemtac/2024/2/jemtac.2024.uncidc.4.html?itemId=/content/journals/10.5339/jemtac.2024.uncidc.4&mimeType=html&fmt=ahah

References

  1. Charalambous M, Raftopoulos V, Paikousis L, Katodritis N, Lambrinou E, Vomvas D, et al. The effect of the use of thyme honey in minimizing radiation - induced oral mucositis in head and neck cancer patients: A randomized controlled trial. Eur J Oncol Nurs. 2018 Jun; 34::89-97. doi: 10.1016/j.ejon.2018.04.003.
    [Google Scholar]
  2. Al-Rawi SAI, Abouelenein H, Nagdy MESE, Alabdei HH, Sulaiman AA, Al-Nuaimi DS, et al. Assessment of dose gradient index variation during simultaneously integrated boost intensity-modulated radiation therapy for head and neck cancer patients. Precision Radiation Oncology. 2022; 6:(3):216-24. doi: 10.1002/pro6.1166.
    [Google Scholar]
  3. Shah S, Rath H, Sharma G, Senapati SN, Mishra E. Effectiveness of curcumin mouthwash on radiation-induced oral mucositis among head and neck cancer patients: A triple-blind, pilot randomised controlled trial. Indian J Dent Res. 2020 Sep-Oct; 31:(5):718-727. doi: 10.4103/ijdr.IJDR_822_18.
    [Google Scholar]
  4. Liu Z, Smart JD, Pannala AS. Recent developments in formulation design for improving oral bioavailability of curcumin: A review. Journal of Drug Delivery Science and Technology. 2020; 60::102082. doi: 10.1016/j.jddst.2020.102082.
    [Google Scholar]
  5. Ashrafizadeh M, Zarrabi A, Hushmandi K, Zarrin V, Moghadam ER, Hashemi F, et al. Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review. Front Pharmacol. 2020 Dec 14; 11::585413. doi: 10.3389/fphar.2020.585413.
    [Google Scholar]
  6. Jagiełło K, Uchańska O, Matyja K, Jackowski M, Wiatrak B, Kubasiewicz-Ross P, et al. Supporting the Wound Healing Process-Curcumin, Resveratrol and Baicalin in In Vitro Wound Healing Studies. Pharmaceuticals (Basel). 2023 Jan 6; 16:(1):82. doi: 10.3390/ph16010082.
    [Google Scholar]
  7. Jaafar NS, Jaafar IS. Natural Products as A Promising Therapy for SARS COV-2; An Overview. Iraqi J Pharm Sci. 2021; 30:(1):29-40.
    [Google Scholar]
  8. Shamash MSA, Zaidan TF. Effect of topical curcumin on the healing of major oral mucosal ulceration. EurAsian Journal of BioSciences. 2020; 14:(2):4653-4660.
    [Google Scholar]
  9. Ramezani V, Ghadirian S, Shabani M, Boroumand MA, Daneshvar R, Saghafi F. Efficacy of curcumin for amelioration of radiotherapy-induced oral mucositis: a preliminary randomized controlled clinical trial. BMC Cancer. 2023 Apr 17; 23:(1):354. doi: 10.1186/s12885-023-10730-8.
    [Google Scholar]
  10. Marovino E, Morgillo A, Mancino N, Di Feo V. Chemotherapy Induced Oral Mucositis: Causes and Treatments. 2022; 4:(5):2046-50. doi: 10.38125/OAJBS.000488.
    [Google Scholar]
  11. Ingrosso G, Saldi S, Marani S, Wong AYW, Bertelli M, Aristei C, Zelante T. Breakdown of Symbiosis in Radiation-Induced Oral Mucositis. J Fungi (Basel). 2021 Apr 12; 7:(4):290. doi: 10.3390/jof7040290.
    [Google Scholar]
  12. Mehanny M, Hathout RM, Geneidi AS, Mansour S. Exploring the use of nanocarrier systems to deliver the magical molecule; Curcumin and its derivatives. J Control Release. 2016 Mar 10; 225::1-30. doi: 10.1016/j.jconrel.2016.01.018.
    [Google Scholar]
  13. Rujirachotiwat A, Suttamanatwong S. Curcumin Promotes Collagen Type I, Keratinocyte Growth Factor-1, and Epidermal Growth Factor Receptor Expressions in the In Vitro Wound Healing Model of Human Gingival Fibroblasts. Eur J Dent. 2021 Feb; 15:(1):63-70. doi: 10.1055/s-0040-1715781.
    [Google Scholar]
  14. Zhang L, Tang G, Wei Z. Prophylactic and Therapeutic Effects of Curcumin on Treatment-Induced Oral Mucositis in Patients with Head and Neck Cancer: A Meta-Analysis of Randomized Controlled Trials. Nutr Cancer. 2021; 73:(5):740-749. doi: 10.1080/01635581.2020.1776884.
    [Google Scholar]
  15. Charantimath S. Use of curcumin in radiochemotherapy induced oral mucositis patients: A control trial study. International Journal of Medical and Health Sciences. 2016; 10:(3):147-52.
    [Google Scholar]
  16. Mansourian A, Amanlou M, SHIRAZIAN S, MOOSAVIAN JZ, Amirian A. The effect of “Curcuma Longa” topical gel on radiation-induced oral mucositis in patients with head and neck cancer. Int J Radiat Res. 2015; 13:(3):269-74. doi: 10.7508/ijrr.2015.03.011.
    [Google Scholar]
  17. Budi HS, Anitasari S, Ulfa NM, Juliastuti WS, Aljunaid M, Ramadan DE, Muzari K, Shen YK. Topical Medicine Potency of Musa paradisiaca var. sapientum (L.) kuntze as Oral Gel for Wound Healing: An In Vitro, In Vivo Study. Eur J Dent. 2022 Oct; 16:(4):848-855. doi: 10.1055/s-0041-1740226.
    [Google Scholar]
  18. Patil K, Guledgud MV, Kulkarni PK, Keshari D, Tayal S. Use of Curcumin Mouthrinse in Radio-Chemotherapy Induced Oral Mucositis Patients: A Pilot Study. J Clin Diagn Res. 2015 Aug; 9:(8):ZC59-62. doi: 10.7860/JCDR/2015/13034.6345.
    [Google Scholar]
  19. Kia SJ, Basirat M, Saedi HS, Arab SA. Effects of nanomicelle curcumin capsules on prevention and treatment of oral mucosits in patients under chemotherapy with or without head and neck radiotherapy: a randomized clinical trial. BMC Complement Med Ther. 2021 Sep 14; 21:(1):232. doi: 10.1186/s12906-021-03400-4.
    [Google Scholar]
  20. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern Med Rev. 2009 Jun; 14:(2):141-53.
    [Google Scholar]
  21. Bengmark S. Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases. JPEN J Parenter Enteral Nutr. 2006 Jan-Feb; 30:(1):45-51. doi: 10.1177/014860710603000145.
    [Google Scholar]
  22. Andrabi SM, Majumder S, Gupta KC, Kumar A. Dextran based amphiphilic nano-hybrid hydrogel system incorporated with curcumin and cerium oxide nanoparticles for wound healing. Colloids Surf B Biointerfaces. 2020 Nov; 195::111263. doi: 10.1016/j.colsurfb.2020.111263.
    [Google Scholar]
  23. Epstein JB, Gorsky M, Guglietta A, Le N, Sonis ST. The correlation between epidermal growth factor levels in saliva and the severity of oral mucositis during oropharyngeal radiation therapy. Cancer. 2000 Dec 1; 89:(11):2258-65. doi: 10.1002/1097-0142(20001201)89:11<2258::aid-cncr14>3.0.co;2-z.
    [Google Scholar]
  24. Epstein JB, Emerton S, Guglietta A, Le N. Assessment of epidermal growth factor in oral secretions of patients receiving radiation therapy for cancer. Oral Oncol. 1997 Sep; 33:(5):359-63. doi: 10.1016/s1368-8375(97)00009-2.
    [Google Scholar]
  25. Dumbrigue HB, Sandow PL, Nguyen KH, Humphreys-Beher MG. Salivary epidermal growth factor levels decrease in patients receiving radiation therapy to the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Jun; 89:(6):710-6. doi: 10.1067/moe.2000.106343.
    [Google Scholar]
  26. Xu J, Yang G, An W, Wang W, Li F, Meng Y, Wang X. Correlations between the severity of radiation-induced oral mucositis and salivary epidermal growth factor as well as inflammatory cytokines in patients with head and neck cancer. Head Neck. 2023 May; 45:(5):1122-9. doi: 10.1002/hed.27313.
    [Google Scholar]
  27. Lee SW, Jung KI, Kim YW, Jung HD, Kim HS, Hong JP. Effect of epidermal growth factor against radiotherapy-induced oral mucositis in rats. Int J Radiat Oncol Biol Phys. 2007 Mar 15; 67:(4):1172-8. doi: 10.1016/j.ijrobp.2006.10.038.
    [Google Scholar]
  28. Shah A, Amini-Nik S. The Role of Phytochemicals in the Inflammatory Phase of Wound Healing. Int J Mol Sci. 2017 May 16; 18:(5):1068. doi: 10.3390/ijms18051068.
    [Google Scholar]
  29. Pakyari M, Farrokhi A, Maharlooei MK, Ghahary A. Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing. Adv Wound Care (New Rochelle). 2013 Jun; 2:(5):215-224. doi: 10.1089/wound.2012.0406.
    [Google Scholar]
  30. Shamash MSA, Zaidan TF. Curcumin modulate TGFβii-R to improve healing of oral ulceration. International Journal of Pharmaceutical Research. 2020; 12:(1):1288-94. doi: 10.31838/ijpr/2020.SP1.206.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5339/jemtac.2024.uncidc.4
Loading
/content/journals/10.5339/jemtac.2024.uncidc.4
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error