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2 - Unified National Conference of Iraqi Dental Colleges (UNCIDC)
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

Dental caries is a heterogeneous microbial infection affecting the mineralized dental tissues and characterized by a gradual demineralization process. Vitamin D aids in the immunological response to oral infections, and its insufficiency can impact the patient’s general and dental health. Small cationic peptides known as cathelicidins are essential for developing innate immune systems. This study aimed to investigate the impact of vitamin D on the innate immune response by assessing the levels of cathelicidin in children with tooth decay.

This study included 60 children aged 4-5 years, with 30 children having caries and 30 without caries. Oral examinations were conducted and scored using the dmfs index. Saliva samples were collected from all subjects, and ELISA was employed to determine vitamin D and cathelicidin levels.

The current findings revealed that salivary levels of cathelicidin and vitamin D were significantly lower (P < 0.01) in children affected by caries than caries-free children. The results also showed a significant decrease (P < 0.01) in cathelicidin levels compared to the vitamin D sufficient group.

The study concludes that children with caries and vitamin D deficiency exhibit low levels of cathelicidin. The observed link between vitamin D deficiency and caries suggests that vitamin D contributes to the synthesis of cathelicidin.

© 2024 Al-Ghurabi, Aldhaher, Abdul Kareem, Abd, Abdullah, Abbas Et Al., Licensee HBKU Press.
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/content/journals/10.5339/jemtac.2024.uncidc.14
2024-03-04
2025-01-26
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References

  1. Singhal R, Siddibhavi M, Sankeshwari R, Patil P, Jalihal S, Ankola A. Effectiveness of three mouthwashes - Manuka honey, Raw honey, and Chlorhexidine on plaque and gingival scores of 12-15-year-old school children: A randomized controlled field trial. J Indian Soc Periodontol. 2018 Jan-Feb; 22:(1):34-39. doi: 10.4103/jisp.jisp_356_17.
     [Google Scholar]
  2. Selwitz RH, Ismail AI, Pitts NB. Dental caries. Lancet. 2007 Jan 6; 369:(9555):51-9. doi: 10.1016/S0140-6736(07)60031-2.
     [Google Scholar]
  3. Veiga NJ, Aires D, Douglas F, Pereira M, Vaz A, Rama L et al. Dental caries: a review. Journal of dental and oral health. 2016 Aug 16; 2:(5):1-3.
    [Google Scholar]
  4. Bover J, Egido J, Fernández-Giráldez E, Praga M, Solozábal-Campos C, Torregrosa JV, et al. Vitamin D, vitamin D receptor and the importance of its activation in patients with chronic kidney disease. Nefrologia. 2015; 35:(1):28-41. English, Spanish. doi: 10.3265/Nefrologia.pre2014.Sep.11796.
     [Google Scholar]
  5. Brown RB, Razzaque MS. Dysregulation of phosphate metabolism and conditions associated with phosphate toxicity. Bonekey Rep. 2015 Jun 3; 4:705. doi: 10.1038/bonekey.2015.74.
     [Google Scholar]
  6. Cagetti MG, Wolf TG, Tennert C, Camoni N, Lingström P, Campus G. The Role of Vitamins in Oral Health. A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2020 Feb 3; 17:(3):938. doi: 10.3390/ijerph17030938.
     [Google Scholar]
  7. Botelho J, Machado V, Proença L, Delgado AS, Mendes JJ. Vitamin D Deficiency and Oral Health: A Comprehensive Review. Nutrients. 2020 May 19; 12:(5):1471. doi: 10.3390/nu12051471.
     [Google Scholar]
  8. Schroth RJ, Rabbani R, Loewen G, Moffatt ME. Vitamin D and Dental Caries in Children. J Dent Res. 2016 Feb; 95:(2):173-9. doi: 10.1177/0022034515616335.
     [Google Scholar]
  9. Wang TT, Nestel FP, Bourdeau V, Nagai Y, Wang Q, Liao J, et al. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol. 2004 Sep 1; 173:(5):2909-12. doi: 10.4049/jimmunol.173.5.2909.
     [Google Scholar]
  10. Oral Health Surveys: Basic Methods - 5th Edition [Internet]. World Health Organization; 2013 [cited 2023 Sept 27]. Available from: https://www.who.int/publications/i/item/9789241548649
     [Google Scholar]
  11. Gyll J, Ridell K, Öhlund I, Karlsland Åkeson P, Johansson I, Lif Holgerson P. Vitamin D status and dental caries in healthy Swedish children. Nutr J. 2018 Jan 16; 17:(1):11. doi: 10.1186/s12937-018-0318-1.
     [Google Scholar]
  12. Al-Daragi FZ, Al-Ghurabi BH. Effect of vitamin D on antimicrobial peptides levels in patients with periodontitis. International Journal of Health Sciences. 2022; 6:S5:8297–8305.
     [Google Scholar]
  13. Al-Ghurabi BH, Adham ZS, Abbas AA. Level of b-defensin among Iraqi patients with COVID-19 in relation to oral health status, Journal of Emergency Medicine, Trauma & Acute Care. 2022:(2):2. doi: 10.5339/jemtac.2022.ismc.2.
     [Google Scholar]
  14. Gordon CM, Williams AL, Feldman HA, May J, Sinclair L, Vasquez A, Cox JE. Treatment of hypovitaminosis D in infants and toddlers. J Clin Endocrinol Metab. 2008 Jul; 93:(7):2716-21. doi: 10.1210/jc.2007-2790.
     [Google Scholar]
  15. Brown T, Creed S, Alexender S, Barnard K, Bridges N, Hancock M. Vitamin D deficiency in children with dental caries- a prevalence study. Arch DIS Child. 2012; 97:(Suppl 1):A103.
     [Google Scholar]
  16. Chhonkar A, Gupta A, Arya V. Comparison of Vitamin D Level of Children with Severe Early Childhood Caries and Children with No Caries. Int J Clin Pediatr Dent. 2018 May-Jun; 11:(3):199-204. doi: 10.5005/jp-journals-10005-1511.
     [Google Scholar]
  17. Ouhara K, Komatsuzawa H, Yamada S, Shiba H, Fujiwara T, Ohara M, et al. Susceptibilities of periodontopathogenic and cariogenic bacteria to antibacterial peptides, {beta}-defensins and LL37, produced by human epithelial cells. J Antimicrob Chemother. 2005 Jun; 55:(6):888-96. doi: 10.1093/jac/dki103.
     [Google Scholar]
  18. Davidopoulou S, Diza E, Menexes G, Kalfas S. Salivary concentration of the antimicrobial peptide LL-37 in children. Arch Oral Biol. 2012 Jul; 57:(7):865-9. doi: 10.1016/j.archoralbio.2012.01.008.
     [Google Scholar]
  19. Al-Ali G, Jafar ZJ and AL-Ghurabi BH. The Relation of Salivary Cathelicidin and Beta-Defensin with Dental Caries of Schoolchildren. J Res Med Dent Sci, 9: (4):30-35, 2021.
     [Google Scholar]
  20. Prasad SV, Fiedoruk K, Daniluk T, Piktel E, Bucki R. Expression and Function of Host Defense Peptides at Inflammation Sites. Int J Mol Sci. 2019 Dec 22; 21:(1):104. doi: 10.3390/ijms21010104.
     [Google Scholar]
  21. Bayirli BA, ÖÖztürk A, Avci B. Serum vitamin D concentration is associated with antimicrobial peptide level in periodontal diseases. Arch Oral Biol. 2020 Sep; 117:104827. doi: 10.1016/j.archoralbio.2020.104827.
     [Google Scholar]
  22. Auvynet C, Rosenstein Y. Multifunctional host defense peptides: antimicrobial peptides, the small yet big players in innate and adaptive immunity. FEBS J. 2009 Nov; 276:(22):6497-508. doi: 10.1111/j.1742-4658.2009.07360.x.
     [Google Scholar]
  23. Raftery T, Martineau AR, Greiller CL, Ghosh S, McNamara D, Bennett K, et al. Effects of vitamin D supplementation on intestinal permeability, cathelicidin and disease markers in Crohn’s disease: Results from a randomised double-blind placebo-controlled study. United European Gastroenterol J. 2015 Jun; 3:(3):294-302. doi: 10.1177/2050640615572176.
     [Google Scholar]
/content/journals/10.5339/jemtac.2024.uncidc.14
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Effect of vitamin D on salivary cathelicidin in kindergarten children with dental caries
Journal of Emergency Medicine, Trauma and Acute Care 2024, 14 (2024); https://doi.org/10.5339/jemtac.2024.uncidc.14
/content/journals/10.5339/jemtac.2024.uncidc.14
/content/journals/10.5339/jemtac.2024.uncidc.14
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Keyword(s): Antimicrobial peptides, cathelicidin, dental caries and vitamin D

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