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2 - Unified National Conference of Iraqi Dental Colleges (UNCIDC)
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

Dental caries is a heterogeneous microbial infection affecting the mineralized dental tissues and characterized by a gradual demineralization process. Vitamin D aids in the immunological response to oral infections, and its insufficiency can impact the patient’s general and dental health. Small cationic peptides known as cathelicidins are essential for developing innate immune systems. This study aimed to investigate the impact of vitamin D on the innate immune response by assessing the levels of cathelicidin in children with tooth decay.

This study included 60 children aged 4-5 years, with 30 children having caries and 30 without caries. Oral examinations were conducted and scored using the dmfs index. Saliva samples were collected from all subjects, and ELISA was employed to determine vitamin D and cathelicidin levels.

The current findings revealed that salivary levels of cathelicidin and vitamin D were significantly lower (P < 0.01) in children affected by caries than caries-free children. The results also showed a significant decrease (P < 0.01) in cathelicidin levels compared to the vitamin D sufficient group.

The study concludes that children with caries and vitamin D deficiency exhibit low levels of cathelicidin. The observed link between vitamin D deficiency and caries suggests that vitamin D contributes to the synthesis of cathelicidin.

© 2024 Al-Ghurabi, Aldhaher, Abdul Kareem, Abd, Abdullah, Abbas Et Al., Licensee HBKU Press.
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/content/journals/10.5339/jemtac.2024.uncidc.14
2024-03-04
2024-05-16
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Effect of vitamin D on salivary cathelicidin in kindergarten children with dental caries
Journal of Emergency Medicine, Trauma and Acute Care 2024, 14 (2024); https://doi.org/10.5339/jemtac.2024.uncidc.14
/content/journals/10.5339/jemtac.2024.uncidc.14
/content/journals/10.5339/jemtac.2024.uncidc.14
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Keyword(s): Antimicrobial peptides, cathelicidin, dental caries and vitamin D

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