1887
3 - Second Mustansiriyah International Dental Conference (MIDC 2023)
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

Hyaluronic acid acts as a barrier to plaque bacteria and fulfills several extracellular functions vital to preserving healthy gingival tissue.

To evaluate the efficacy of 0.2% Hyaluronic Acid Comprising Gel (Gingegel), combined with motivation, instruction, and scaling polishing to decrease gum inflammation among patients with gingivitis.

This was a parallel-design, double-blind, randomized control trial involving plaque-induced gingivitis patients 19–40 years of age. The sample was divided into two groups: Group 1 (n=20) was the test group, receiving motivation, instruction, scaling, polishing, and Gingegel application, and Group 2 (n=30) was the control group, receiving motivation, instruction, scaling, and polishing only. Each patient’s plaque and gingival indices were recorded at baseline and after two weeks of treatment.

There was a statistically significant enhancement in the clinical parameters of both groups after two weeks, including a reduction in the Plaque index (PLI) from 0.967 at baseline to 0.663 after two weeks and mean reductions in the Gingival Index (GI) from 0.994 at baseline to 0.725 after two weeks (p <0.001).

There was a statistically significant decrease in GI of the total sample (including the test and control groups) at baseline and after two weeks.

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2023-07-23
2024-06-14
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References

  1. Loe, H.; Theilade, E.; Jensen, S.B. Experimental gingivitis in man. J. Periodontol, 1965, 36:, 177-87.
    [Google Scholar]
  2. Barnes, V.M.; Richter, R.; Bastin, D.; Lambert, P.; Xu, T. Dental plaque control effect of a zinc citrate dentifrice. J. Clin. Dent, 2008, 19:(4), 127-130.
    [Google Scholar]
  3. Caton, J.; Bouwsma, O.; Polson, A.; Epseland, M. Effect of personal oral hygiene and subgingival scaling on bleeding interdental gingiva. J Periodontol, 1989, 60:, 84-90.
    [Google Scholar]
  4. Moseley, R.I.; Waddington, R.J.; Embery, G. Hyaluronan and its Potential Role in Periodontal Healing. Dental Update, 2002, 29:, 144-148.
    [Google Scholar]
  5. Pilloni, A.; Bernard, G.W. Low molecular weight hyaluronic acid increases osteogenesis in vitro. J Dent Research, 1992, 71:, 574.
    [Google Scholar]
  6. Feinberg, R.N.; Beebe, D.C. Hyaluronate in vasculogenesis. Science, 1983, 220:, 1177-1179.
    [Google Scholar]
  7. Yıldırım, S.; Ozener, H.O.; Do˘gan, B.; Kuru, B. Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: an examiner-masked, randomized, controlled clinical trial. J Periodontol, 2018, 89:(1), 36-45.
    [Google Scholar]
  8. Hammad, H.; Hammad, M.; Abdelhadi, I.; Khalifeh, M. Effects of topically applied agents on intra-oral wound healing in a rat model: a clinical and histomorphometric study. Int. J. Dental Hygiene, 2011, 9:(1), 9-16.
    [Google Scholar]
  9. Finn, M.D.; Schow, S.R.; Schneiderman, E.D. Osseous regeneration in the presence of four common hemostatic agents. J. Oral Maxillofacial Surg, 1992, 50:(6), 608-612.
    [Google Scholar]
  10. Fawzy El-Sayed, K.M.; Dahaba, M.A.; Aboul-Ela, S.; Darhous, M.S. Local application of hyaluronan gel in conjunction with periodontal surgery: a randomized controlled trial. Clin. Oral Investigations, 2012, 16:(4), 1229-1236.
    [Google Scholar]
  11. Jentsch, H.; Pomowski, R.; Kundt, G.; Gocke, R.; Treatment of gingivitis with hyaluronan. J. Clin. Periodontol. 2003; 30:, 159-164.
    [Google Scholar]
  12. Galgut, P.N. The role of hyaluronic acid in managing inflammation in periodontal diseases. Dental Health, 2002, 42:, 3-5.
    [Google Scholar]
  13. Sapudom, J.; Müller, C.D.; Nguyen, K.-T.; Martin, S.; Anderegg, U.; Pompe, T. Matrix Remodeling and Hyaluronan Production by Myofibroblasts and Cancer-Associated Fibroblasts in 3D Collagen Matrices. Gels, 2020, 6:, 33.
    [Google Scholar]
  14. Gupta, R.C.; Lall, R.; Srivastava, A.; Sinha, A. Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory. Front. Vet. Sci., 2019, 6:, 192.
    [Google Scholar]
  15. Tiwari, S.; Bahadur, P. Modified hyaluronic acid-based materials for biomedical applications. Int. J. Biol. Macromol., 2019, 121:, 556-571.
    [Google Scholar]
  16. Fallacara, A.; Baldini, E.; Manfredini, S.; Vertuani, S. Hyaluronic Acid in the Third Millennium. Polymers, 2018, 10:, 701.
    [Google Scholar]
  17. Huang, G.; Huang, H. Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system. J. Control Release, 2018, 278:, 122-126.
    [Google Scholar]
  18. Vangelisti, R.; Pagnacco, O.; Erra, C. Hyaluronic acid in the topical treatment of gingival inflammations: Preliminary clinical trial. Attual Ter. Internazionale, 1997, 15:, 2-3.
    [Google Scholar]
  19. Silness, J.; Löe, H. (1964) ‘Periodontal disease in pregnancy II. Correlation between oral hygiene and periodontal condition’, Acta Odontologica Scandinavica, 1964, 22:(1), 121-135.
    [Google Scholar]
  20. Solis, C.; Santos, A.; Nart, J.; Violant, D. 0.2% Chlorhexidi Mouthwash with an Anti-Discoloration System Versus Chlorhexidine Mouthwash. A Prospective Clinical 0.2 Comparative Study. J. Periodontol, 2010.
    [Google Scholar]
  21. Marsh, P.D. Controlling the oral biofilm with antimicrobials. J. Dent., 2010; 38:(Supp 1), S11-55.
    [Google Scholar]
  22. Mantovani, S.; Sala Tesciat, A.; Fossati, B. Preliminary clinical evaluation of a hyaluronic acid-based product in oral disorders: Double-blind trial. Attual Ter. Internazionale. 1998, 16:, 1-5.
    [Google Scholar]
  23. Brandimorte. Hyaluronic acid and periodontopathies. Minerva Stomatol., 1968, 17:, 140-56.
    [Google Scholar]
  24. Oksala, O.; Salo, T.; Tammi, R.; Hakkinen, L.; Jalkanen, M.; Inki, P. et al. Expression of proteoglycans and hyaluronan during wound healing. J Histochem. Cytochem., 1995, 43:, 125-35.
    [Google Scholar]
  25. Mesa, F.L.; Aneiros, J.; Cabrera, A.; Bravo, M.; Caballero, T.; Revelles, F, et al. Antiproliferative effect of topical hyaluronic acid gel: Study in gingival biopsies of patients with periodontal disease. Histol. Histopathol., 2002, 17:, 747-53.
    [Google Scholar]
  26. Chilton, N.W., Fleiss, J.L. Design and analysis of plaque and gingivitis clinical trials. J. Clin. Periodontol., 1986, 13:, 400-410.
    [Google Scholar]
  27. Suresh, D.K.; Vandana, K.L. Intracrevicular application of 0.3% flurbiprofen gel and 0.3% triclosan gel as an anti-inflammatory agent. A comparative clinical study. Indian J. Dent. Res., 2001, 12:, 105-212.
    [Google Scholar]
  28. Pagnacco, A.; Vangelisti, R.; Erra, C.; Poma, A. Double-blind clinical trial Vs. placebo of a new sodium-hyaluronate-based gingival gel. Actual Ter. Internazionale., 1997, 15:, 1-7.
    [Google Scholar]
  29. Nowicki, D.; Vogel, R.I.; Melcer, S.; Deasy, M.J. The gingival bleeding time index. J. Periodontol. 1981, 52:, 260-262.
    [Google Scholar]
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