1887
Volume 2020, Issue 2
  • ISSN: 1999-7086
  • EISSN: 1999-7094

Abstract

Deliberate self-harm (DSH) is an important cause for intensive care admission in developing countries. The evaluation of incidence and risk factors for nosocomial infection development in DSH with its impact on the outcome is not clearly elucidated. Demographic, infection, and outcome data were collected in this retrospective study of 2 years. Factors associated with infection and mortality were explored using bivariate and multivariate logistic regression analyses, which were expressed as odds ratio (OR) with 95% confidence interval (CI). Of the 3274 admissions, 302 (9.2%) were due to DSH, whereas the majority (n = 178, 58.9%) were due to organophosphorus (OP) compounds, with the mean (SD) APACHE-II score of 14.7 (6.0); 278 (92.1%) patients were ventilated. 55 (18.2%) patients developed a nosocomial infection, accounting for 15.6 infections per 1000 hospital days, with an overall mortality of 14.2%. Mortality was significantly ( < 0.001) higher in those who developed an infection (30.9% vs. 10.5%). Multivariate logistic regression analysis demonstrated that DSH due to OP compounds (OR 2.9; 95%CI 1.1–7.1) and ventilation duration (OR 1.1; 95%CI 1.1–1.3) were independently associated with nosocomial infection development. APACHE-II score, nosocomial infection, and the need for dialysis significantly ( < 0.001) associated with mortality. In the DSH setting, acquiring nosocomial infection during intensive care admission impacts mortality. DSH due to OP compounds and duration of ventilation were independent risk factors for the development of infection.

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2021-02-03
2021-07-28
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  • Article Type: Research Article
Keyword(s): infection , intensive care , outcome and pesticide
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