1887
Volume 2014, Issue 1
  • ISSN: 2305-7823
  • E-ISSN:

Abstract

The Indian Asian population accounts for a fifth of all global deaths from coronary heart disease (CHD). CHD deaths on the Indian subcontinent have doubled since 1990, and are predicted to rise a further 50% by 2030. Reasons underlying the increased CHD mortality among Indian Asians remain unknown. Although conventional cardiovascular risk factors contribute to CHD in Indian Asians as in other populations, these do not account for their increased risk. Type-2 diabetes, insulin resistance and related metabolic disturbances are more prevalent amongst Indian Asians than Europeans, and have been proposed as major determinants of higher CHD risk among Indian Asians. However, this view is not supported by prospective data. Genome-wide association studies have not identified differences in allele frequencies or effect sizes in known loci to explain the increased CHD risk in Indian Asians. Limited knowledge of mechanisms underlying higher CHD risk amongst Indian Asians presents a major obstacle to reducing the burden of CHD in this population. Systems biology approaches such as genomics, epigenomics, metabolomics and transcriptomics, provide a non-biased approach for discovery of novel biomarkers and disease pathways underlying CHD. Incorporation of these ‘omic’ approaches in prospective Indian Asian cohorts such as the London Life Sciences Population Study (LOLIPOP) provide an exciting opportunity for the identification of new risk factors underlying CHD in this high risk population.

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2014-07-01
2019-08-17
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References

  1. [1]. Lozano   R., , Naghavi   M., , Foreman   K., , Lim   S., , Shibuya   K., , Aboyans   V., , Abraham   J., , Adair   T., , Aggarwal   R., , Ahn   SY., , Alvarado   M., , Anderson   HR., , Anderson   LM., , Andrews   KG., , Atkinson   C., , Baddour   LM., , Barker-Collo   S., , Bartels   DH., , Bell   ML., , Benjamin   EJ., , Bennett   D., , Bhalla   K., , Bikbov   B., , BinAbdulhak   A., , Birbeck   G., , Blyth   F., , Bolliger   I., , Boufous   S., , Bucello   C., , Burch   M., , Burney   P., , Carapetis   J., , Chen   H., , Chou   D., , Chugh   SS., , Coffeng   LE., , Colan   SD., , Colquhoun   S., , Colson   KE., , Condon   J., , Connor   MD., , Cooper   LT., , Corriere   M., , Cortinovis   M., , de Vaccaro   KC., , Couser   W., , Cowie   BC., , Criqui   MH., , Cross   M., , Dabhadkar   KC., , Dahodwala   N., , De Leo   D., , Degenhardt   L., , Delossantos   A., , Denenberg   J., , Des Jarlais   DC., , Dharmaratne   SD., , Dorsey   ER., , Driscoll   T., , Duber   H., , Ebel   B., , Erwin   PJ., , Espindola   P., , Ezzati   M., , Feigin   V., , Flaxman   AD., , Forouzanfar   MH., , Fowkes   FG., , Franklin   R., , Fransen   M., , Freeman   MK., , Gabriel   SE., , Gakidou   E., , Gaspari   F., , Gillum   RF., , Gonzalez-Medina   D., , Halasa   YA., , Haring   D., , Harrison   JE., , Havmoeller   R., , Hay   RJ., , Hoen   B., , Hotez   PJ., , Hoy   D., , Jacobsen   KH., , James   SL., , Jasrasaria   R., , Jayaraman   S., , Johns   N., , Karthikeyan   G., , Kassebaum   N., , Keren   A., , Khoo   JP., , Knowlton   LM., , Kobusingye   O., , Koranteng   A., , Krishnamurthi   R., , Lipnick   M., , Lipshultz   SE., , Ohno   SL., , Mabweijano   J., , MacIntyre   MF., , Mallinger   L., , March   L., , Marks   GB., , Marks   R., , Matsumori   A., , Matzopoulos   R., , Mayosi   BM., , McAnulty   JH., , McDermott   MM., , McGrath   J., , Mensah   GA., , Merriman   TR., , Michaud   C., , Miller   M., , Miller   TR., , Mock   C., , Mocumbi   AO., , Mokdad   AA., , Moran   A., , Mulholland   K., , Nair   MN., , Naldi   L., , Narayan   KM., , Nasseri   K., , Norman   P., , O'Donnell   M., , Omer   SB., , Ortblad   K., , Osborne   R., , Ozgediz   D., , Pahari   B., , Pandian   JD., , Rivero   AP., , Padilla   RP., , Perez-Ruiz   F., , Perico   N., , Phillips   D., , Pierce   K., , Pope   CA 3rd., , Porrini   E., , Pourmalek   F., , Raju   M., , Ranganathan   D., , Rehm   JT., , Rein   DB., , Remuzzi   G., , Rivara   FP., , Roberts   T., , De León   FR., , Rosenfeld   LC., , Rushton   L., , Sacco   RL., , Salomon   JA., , Sampson   U., , Sanman   E., , Schwebel   DC., , Segui-Gomez   M., , Shepard   DS., , Singh   D., , Singleton   J., , Sliwa   K., , Smith   E., , Steer   A., , Taylor   JA., , Thomas   B., , Tleyjeh   IM., , Towbin   JA., , Truelsen   T., , Undurraga   EA., , Venketasubramanian   N., , Vijayakumar   L., , Vos   T., , Wagner   GR., , Wang   M., , Wang   W., , Watt   K., , Weinstock   MA., , Weintraub   R., , Wilkinson   JD., , Woolf   AD., , Wulf   S., , Yeh   PH., , Yip   P., , Zabetian   A., , Zheng   ZJ., , Lopez   AD., , Murray   CJ., , AlMazroa   MA., , Memish   ZA. . Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. . Lancet . 2012; ;380: 9859 : 2095– 2128 .
    [Google Scholar]
  2. [2]. Mathers   CD., , Loncar   D. . Projections of global mortality and burden of disease from 2002 to 2030. . PLoS Med . 2006; ;3: 11 : e442 .
    [Google Scholar]
  3. [3]. Gupta   R., , Joshi   P., , Mohan   V., , Reddy   KS., , Yusuf   S. . Epidemiology and causation of coronary heart disease and stroke in India. . Heart . 2008; ;94: 1 : 16– 26 .
    [Google Scholar]
  4. [4]. Murthy   PD., , Prasad   KT., , Gopal   PV., , Rao   KV., , Rao   RM. . A survey for prevalence of coronary artery disease and its risk factors in an urban population in Andhra Pradesh. . J Assoc Physicians India . 2012; ;60: : 17– 20 .
    [Google Scholar]
  5. [5]. Census of India. Government of India, Ministry of Home Affairs. CensusInfo India 2011 http://censusindia.gov.in/ .
  6. [6]. Leeder   S., , Raymond   S., , Greenberg   H., , Liu   H., , Esson   K. . A race against time. The challenge of cardiovascular disease in developing economies . New York: : Columbia University;   2004; .
    [Google Scholar]
  7. [7]. WHO global report 2005 – Preventing chronic diseases: a vital investment. Geneva: World Health Organization. 2005 .
  8. [8]. Harding   S., , Rosato   M., , Teyhan   A. . Trends for coronary heart disease and stroke mortality among migrants in England and Wales, 1979-2003: slow declines notable for some groups. . Heart . 2008; ;94: 4 : 463– 470 .
    [Google Scholar]
  9. [9]. McKeigue   PM., , Miller   GJ., , Marmot   MG. . Coronary heart disease in south Asians overseas: a review. . J Clin Epidemiol . 1989; ;42: 7 : 597– 609 .
    [Google Scholar]
  10. [10]. Wild   SH., , Laws   A., , Fortmann   SP., , Varady   AN., , Byrne   CD. . Mortality from coronary heart disease and stroke for six ethnic groups in California, 1985 to 1990. . Ann Epidemiol . 1995; ;5: 6 : 432– 439 .
    [Google Scholar]
  11. [11]. Palaniappan   L., , Wang   Y., , Fortmann   SP. . Coronary heart disease mortality for six ethnic groups in California, 1990-2000. . Ann Epidemiol . 2004; ;14: 7 : 499– 506 .
    [Google Scholar]
  12. [12]. Sheth   T., , Nair   C., , Nargundkar   M., , Anand   S., , Yusuf   S. . Cardiovascular and cancer mortality among Canadians of European, south Asian and Chinese origin from 1979 to 1993: an analysis of 1.2 million deaths. . CMAJ . 1999; ;161: 2 : 132– 138 .
    [Google Scholar]
  13. [13]. Anand   SS., , Yusuf   S., , Vuksan   V., , Devanesen   S., , Teo   KK., , Montague   PA., , Kelemen   L., , Yi   C., , Lonn   E., , Gerstein   H., , Hegele   RA., , McQueen   M. . Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE). . Lancet . 2000; ;356: 9226 : 279– 284 .
    [Google Scholar]
  14. [14]. Hughes   K., , Lun   KC., , Yeo   PP. . Cardiovascular diseases in Chinese, Malays, and Indians in Singapore. I. Differences in mortality. . J Epidemiol Community Health . 1990; ;44: 1 : 24– 28 .
    [Google Scholar]
  15. [15]. Mak   KH., , Chia   KS., , Kark   JD., , Chua   T., , Tan   C., , Foong   BH., , Lim   YL., , Chew   SK. . Ethnic differences in acute myocardial infarction in Singapore. . Eur Heart J . 2003; ;24: 2 : 151– 160 .
    [Google Scholar]
  16. [16]. Tuomilehto   J., , Li   N., , Dowse   G., , Gareeboo   H., , Chitson   P., , Fareed   D., , Min   Z., , Alberti   KG., , Zimmet   P. . The prevalence of coronary heart disease in the multi-ethnic and high diabetes prevalence population of Mauritius. . J Intern Med . 1993; ;233: 2 : 187– 194 .
    [Google Scholar]
  17. [17]. Magliano   DJ., , Söderberg   S., , Zimmet   PZ., , Cartensen   B., , Balkau   B., , Pauvaday   V., , Kowlessur   S., , Tuomilehto   J., , Alberti   KG., , Shaw   JE. . Mortality, all-cause and cardiovascular disease, over 15 years in multiethnic mauritius: impact of diabetes and intermediate forms of glucose tolerance. . Diabetes Care . 2010; ;33: 9 : 1983– 1989 .
    [Google Scholar]
  18. [18]. Derry   CW., , Bourne   DE., , Sayed   AR., , Disler   PB., , Rip   MR., , Taylor   SP., , Whittaker   S., , Klopper   JM., , Epstein   L. . Variations in mortality of the coloured, white and Asian population groups in the RSA, 1978-1982. Part VI. Ischaemic heart disease. . S Afr Med J . 1987; ;72: 10 : 698– 700 .
    [Google Scholar]
  19. [19]. Miller   GJ., , Beckles   GL., , Maude   GH., , Carson   DC., , Alexis   SD., , Price   SG., , Byam   NT. . Ethnicity and other characteristics predictive of coronary heart disease in a developing community: principal results of the St James Survey, Trinidad. . Int J Epidemiol . 1989; ;18: 4 : 808– 817 .
    [Google Scholar]
  20. [20]. Yusuf   S., , Hawken   S., , Ounpuu   S., , Dans   T., , Avezum   A., , Lanas   F., , McQueen   M., , Budaj   A., , Pais   P., , Varigos   J., , Lisheng   L., , INTERHEART Study Investigators. . Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. . Lancet . 2004; ;364: 9438 : 937– 952 .
    [Google Scholar]
  21. [21]. McKeigue   PM., , Marmot   MG., , Adelstein   AM., , Hunt   SP., , Shipley   MJ., , Butler   SM., , Riemersma   RA., , Turner   PR. . Diet and risk factors for coronary heart disease in Asians in northwest London. . Lancet . 1985; ;2: 8464 : 1086– 1090 .
    [Google Scholar]
  22. [22]. McKeigue   PM., , Marmot   MG., , Syndercombe Court   YD., , Cottier   DE., , Rahman   S., , Riemersma   RA. . Diabetes, hyperinsulinaemia, and coronary risk factors in Bangladeshis in east London. . Br Heart J . 1988; ;60: 5 : 390– 396 .
    [Google Scholar]
  23. [23]. McKeigue   PM., , Ferrie   JE., , Pierpoint   T., , Marmot   MG. . Association of early-onset coronary heart disease in South Asian men with glucose intolerance and hyperinsulinemia. . Circulation . 1993; ;87: 1 : 152– 161 .
    [Google Scholar]
  24. [24]. Forouhi   NG., , Sattar   N., , Tillin   T., , McKeigue   PM., , Chaturvedi   N. . Do known risk factors explain the higher coronary heart disease mortality in South Asian compared with European men? Prospective follow-up of the Southall and Brent studies, UK. . Diabetologia . 2006; ;49: 11 : 2580– 2588 .
    [Google Scholar]
  25. [25]. Chahal   NS., , Lim   TK., , Jain   P., , Chambers   JC., , Kooner   JS., , Senior   R. . Normative reference values for the tissue Doppler imaging parameters of left ventricular function: a population-based study. . Eur J Echocardiogr . 2010; ;11: 1 : 51– 56 .
    [Google Scholar]
  26. [26]. Chahal   NS., , Lim   TK., , Jain   P., , Chambers   JC., , Kooner   JS., , Senior   R. . Population-based reference values for 3D echocardiographic LV volumes and ejection fraction. . JACC Cardiovasc Imaging . 2012; ;5: 12 : 1191– 1197 .
    [Google Scholar]
  27. [27]. Chambers   JC., , Zhang   W., , Sehmi   J., , Li   X., , Wass   MN., , Van der Harst   P., , Holm   H., , Sanna   S., , Kavousi   M., , Baumeister   SE., , Coin   LJ., , Deng   G., , Gieger   C., , Heard-Costa   NL., , Hottenga   JJ., , Kühnel   B., , Kumar   V., , Lagou   V., , Liang   L., , Luan   J., , Vidal   PM., , Mateo Leach   I., , O'Reilly   PF., , Peden   JF., , Rahmioglu   N., , Soininen   P., , Speliotes   EK., , Yuan   X., , Thorleifsson   G., , Alizadeh   BZ., , Atwood   LD., , Borecki   IB., , Brown   MJ., , Charoen   P., , Cucca   F., , Das   D., , de Geus   EJ., , Dixon   AL., , Döring   A., , Ehret   G., , Eyjolfsson   GI., , Farrall   M., , Forouhi   NG., , Friedrich   N., , Goessling   W., , Gudbjartsson   DF., , Harris   TB., , Hartikainen   AL., , Heath   S., , Hirschfield   GM., , Hofman   A., , Homuth   G., , Hyppönen   E., , Janssen   HL., , Johnson   T., , Kangas   AJ., , Kema   IP., , Kühn   JP., , Lai   S., , Lathrop   M., , Lerch   MM., , Li   Y., , Liang   TJ., , Lin   JP., , Loos   RJ., , Martin   NG., , Moffatt   MF., , Montgomery   GW., , Munroe   PB., , Musunuru   K., , Nakamura   Y., , O'Donnell   CJ., , Olafsson   I., , Penninx   BW., , Pouta   A., , Prins   BP., , Prokopenko   I., , Puls   R., , Ruokonen   A., , Savolainen   MJ., , Schlessinger   D., , Schouten   JN., , Seedorf   U., , Sen-Chowdhry   S., , Siminovitch   KA., , Smit   JH., , Spector   TD., , Tan   W., , Teslovich   TM., , Tukiainen   T., , Uitterlinden   AG., , Van der Klauw   MM., , Vasan   RS., , Wallace   C., , Wallaschofski   H., , Wichmann   HE., , Willemsen   G., , Würtz   P., , Xu   C., , Yerges-Armstrong   LM., , AlcoholGenome-wide Association (AlcGen) Consortium; Diabetes Genetics Replication and Meta-analyses (DIAGRAM) Study; Genetic Investigation of Anthropometric Traits (GIANT) Consortium; Global Lipids Genetics Consortium; Genetics of Liver Disease (GOLD) Consortium; International Consortium for Blood Pressure (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC)., , Abecasis   GR., , Ahmadi   KR., , Boomsma   DI., , Caulfield   M., , Cookson   WO., , van Duijn   CM., , Froguel   P., , Matsuda   K., , McCarthy   MI., , Meisinger   C., , Mooser   V., , Pietiläinen   KH., , Schumann   G., , Snieder   H., , Sternberg   MJ., , Stolk   RP., , Thomas   HC., , Thorsteinsdottir   U., , Uda   M., , Waeber   G., , Wareham   NJ., , Waterworth   DM., , Watkins   H., , Whitfield   JB., , Witteman   JC., , Wolffenbuttel   BH., , Fox   CS., , Ala-Korpela   M., , Stefansson   K., , Vollenweider   P., , Völzke   H., , Schadt   EE., , Scott   J., , Järvelin   MR., , Elliott   P., , Kooner   JS. . Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. . Nat Genet . 2011; ;43: 11 : 1131– 1138 .
    [Google Scholar]
  28. [28]. Chahal   NS., , Lim   TK., , Jain   P., , Chambers   JC., , Kooner   JS., , Senior   R. . The increased prevalence of left ventricular hypertrophy and concentric remodeling in UK Indian Asians compared with European Whites. . J Hum Hypertens . 2013; ;27: 5 : 288– 293 .
    [Google Scholar]
  29. [29]. Chahal   NS., , Lim   TK., , Jain   P., , Chambers   JC., , Kooner   JS., , Senior   R. . Does subclinical atherosclerosis burden identify the increased risk of cardiovascular disease mortality among United Kingdom Indian Asians? A population study. . Am Heart J . 2011; ;162: 3 : 460– 466 .
    [Google Scholar]
  30. [30]. Zabaneh   D., , Chambers   JC., , Elliott   P., , Scott   J., , Balding   DJ., , Kooner   JS. . Heritability and genetic correlations of insulin resistance and component phenotypes in Asian Indian families using a multivariate analysis. . Diabetologia   2009; ;52: 12 : 2585– 2589 .
    [Google Scholar]
  31. [31]. Coronary Artery Disease (C4D) Genetics Consortium . genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. . Nat Genet . 2011; ;43: 4 : 339– 344 .
    [Google Scholar]
  32. [32]. Schunkert   H., , König   IR., , Kathiresan   S., , Reilly   MP., , Assimes   TL., , Holm   H., , Preuss   M., , Stewart   AF., , Barbalic   M., , Gieger   C., , Absher   D., , Aherrahrou   Z., , Allayee   H., , Altshuler   D., , Anand   SS., , Andersen   K., , Anderson   JL., , Ardissino   D., , Ball   SG., , Balmforth   AJ., , Barnes   TA., , Becker   DM., , Becker   LC., , Berger   K., , Bis   JC., , Boekholdt   SM., , Boerwinkle   E., , Braund   PS., , Brown   MJ., , Burnett   MS., , Buysschaert   I., , Cardiogenics., , Carlquist   JF., , Chen   L., , Cichon   S., , Codd   V., , Davies   RW., , Dedoussis   G., , Dehghan   A., , Demissie   S., , Devaney   JM., , Diemert   P., , Do   R., , Doering   A., , Eifert   S., , Mokhtari   NE., , Ellis   SG., , Elosua   R., , Engert   JC., , Epstein   SE., , de Faire   U., , Fischer   M., , Folsom   AR., , Freyer   J., , Gigante   B., , Girelli   D., , Gretarsdottir   S., , Gudnason   V., , Gulcher   JR., , Halperin   E., , Hammond   N., , Hazen   SL., , Hofman   A., , Horne   BD., , Illig   T., , Iribarren   C., , Jones   GT., , Jukema   JW., , Kaiser   MA., , Kaplan   LM., , Kastelein   JJ., , Khaw   KT., , Knowles   JW., , Kolovou   G., , Kong   A., , Laaksonen   R., , Lambrechts   D., , Leander   K., , Lettre   G., , Li   M., , Lieb   W., , Loley   C., , Lotery   AJ., , Mannucci   PM., , Maouche   S., , Martinelli   N., , McKeown   PP., , Meisinger   C., , Meitinger   T., , Melander   O., , Merlini   PA., , Mooser   V., , Morgan   T., , Mühleisen   TW., , Muhlestein   JB., , Münzel   T., , Musunuru   K., , Nahrstaedt   J., , Nelson   CP., , Nöthen   MM., , Olivieri   O., , Patel   RS., , Patterson   CC., , Peters   A., , Peyvandi   F., , Qu   L., , Quyyumi   AA., , Rader   DJ., , Rallidis   LS., , Rice   C., , Rosendaal   FR., , Rubin   D., , Salomaa   V., , Sampietro   ML., , Sandhu   MS., , Schadt   E., , Schäfer   A., , Schillert   A., , Schreiber   S., , Schrezenmeir   J., , Schwartz   SM., , Siscovick   DS., , Sivananthan   M., , Sivapalaratnam   S., , Smith   A., , Smith   TB., , Snoep   JD., , Soranzo   N., , Spertus   JA., , Stark   K., , Stirrups   K., , Stoll   M., , Tang   WH., , Tennstedt   S., , Thorgeirsson   G., , Thorleifsson   G., , Tomaszewski   M., , Uitterlinden   AG., , van Rij   AM., , Voight   BF., , Wareham   NJ., , Wells   GA., , Wichmann   HE., , Wild   PS., , Willenborg   C., , Witteman   JC., , Wright   BJ., , Ye   S., , Zeller   T., , Ziegler   A., , Cambien   F., , Goodall   AH., , Cupples   LA., , Quertermous   T., , März   W., , Hengstenberg   C., , Blankenberg   S., , Ouwehand   WH., , Hall   AS., , Deloukas   P., , Thompson   JR., , Stefansson   K., , Roberts   R., , Thorsteinsdottir   U., , O'Donnell   CJ., , McPherson   R., , Erdmann   J., , CARDIoGRAM Consortium., , Samani   NJ. . Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. . Nat Genet . 2011; ;43: 4 : 333– 338 .
    [Google Scholar]
  33. [33]. CARDIoGRAMplusC4D Consortium., , Deloukas   P., , Kanoni   S., , Willenborg   C., , Farrall   M., , Assimes   TL., , Thompson   JR., , Ingelsson   E., , Saleheen   D., , Erdmann   J., , Goldstein   BA., , Stirrups   K., , König   IR., , Cazier   JB., , Johansson   A., , Hall   AS., , Lee   JY., , Willer   CJ., , Chambers   JC., , Esko   T., , Folkersen   L., , Goel   A., , Grundberg   E., , Havulinna   AS., , Ho   WK., , Hopewell   JC., , Eriksson   N., , Kleber   ME., , Kristiansson   K., , Lundmark   P., , Lyytikäinen   LP., , Rafelt   S., , Shungin   D., , Strawbridge   RJ., , Thorleifsson   G., , Tikkanen   E., , Van Zuydam   N., , Voight   BF., , Waite   LL., , Zhang   W., , Ziegler   A., , Absher   D., , Altshuler   D., , Balmforth   AJ., , Barroso   I., , Braund   PS., , Burgdorf   C., , Claudi-Boehm   S., , Cox   D., , Dimitriou   M., , Do   R., , DIAGRAM Consortium; CARDIOGENICS Consortium., , Doney   AS., , El Mokhtari   N., , Eriksson   P., , Fischer   K., , Fontanillas   P., , Franco-Cereceda   A., , Gigante   B., , Groop   L., , Gustafsson   S., , Hager   J., , Hallmans   G., , Han   BG., , Hunt   SE., , Kang   HM., , Illig   T., , Kessler   T., , Knowles   JW., , Kolovou   G., , Kuusisto   J., , Langenberg   C., , Langford   C., , Leander   K., , Lokki   ML., , Lundmark   A., , McCarthy   MI., , Meisinger   C., , Melander   O., , Mihailov   E., , Maouche   S., , Morris   AD., , Müller-Nurasyid   M., , MuTHER Consortium., , Nikus   K., , Peden   JF., , Rayner   NW., , Rasheed   A., , Rosinger   S., , Rubin   D., , Rumpf   MP., , Schäfer   A., , Sivananthan   M., , Song   C., , Stewart   AF., , Tan   ST., , Thorgeirsson   G., , van der Schoot   CE., , Wagner   PJ., , Wellcome Trust Case Control Consortium., , Wells   GA., , Wild   PS., , Yang   TP., , Amouyel   P., , Arveiler   D., , Basart   H., , Boehnke   M., , Boerwinkle   E., , Brambilla   P., , Cambien   F., , Cupples   AL., , de Faire   U., , Dehghan   A., , Diemert   P., , Epstein   SE., , Evans   A., , Ferrario   MM., , Ferrières   J., , Gauguier   D., , Go   AS., , Goodall   AH., , Gudnason   V., , Hazen   SL., , Holm   H., , Iribarren   C., , Jang   Y., , Kähönen   M., , Kee   F., , Kim   HS., , Klopp   N., , Koenig   W., , Kratzer   W., , Kuulasmaa   K., , Laakso   M., , Laaksonen   R., , Lee   JY., , Lind   L., , Ouwehand   WH., , Parish   S., , Park   JE., , Pedersen   NL., , Peters   A., , Quertermous   T., , Rader   DJ., , Salomaa   V., , Schadt   E., , Shah   SH., , Sinisalo   J., , Stark   K., , Stefansson   K., , Trégouët   DA., , Virtamo   J., , Wallentin   L., , Wareham   N., , Zimmermann   ME., , Nieminen   MS., , Hengstenberg   C., , Sandhu   MS., , Pastinen   T., , Syvänen   AC., , Hovingh   GK., , Dedoussis   G., , Franks   PW., , Lehtimäki   T., , Metspalu   A., , Zalloua   PA., , Siegbahn   A., , Schreiber   S., , Ripatti   S., , Blankenberg   SS., , Perola   M., , Clarke   R., , Boehm   BO., , O'Donnell   C., , Reilly   MP., , März   W., , Collins   R., , Kathiresan   S., , Hamsten   A., , Kooner   JS., , Thorsteinsdottir   U., , Danesh   J., , Palmer   CN., , Roberts   R., , Watkins   H., , Schunkert   H., , Samani   NJ. . Large-scale association analysis identifies new risk loci for coronary artery disease. . Nat Genet . 2012; ;45: 1 : 25– 33 .
    [Google Scholar]
  34. [34]. Davies   RW., , Wells   GA., , Stewart   AF., , Erdmann   J., , Shah   SH., , Ferguson   JF., , Hall   AS., , Anand   SS., , Burnett   MS., , Epstein   SE., , Dandona   S., , Chen   L., , Nahrstaedt   J., , Loley   C., , König   IR., , Kraus   WE., , Granger   CB., , Engert   JC., , Hengstenberg   C., , Wichmann   HE., , Schreiber   S., , Tang   WH., , Ellis   SG., , Rader   DJ., , Hazen   SL., , Reilly   MP., , Samani   NJ., , Schunkert   H., , Roberts   R., , McPherson   R. . A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. . Circ Cardiovasc Genet . 2012; ;5: 2 : 217– 225 .
    [Google Scholar]
  35. [35]. Manolio   TA., , Collins   FS., , Cox   NJ., , Goldstein   DB., , Hindorff   LA., , Hunter   DJ., , McCarthy   MI., , Ramos   EM., , Cardon   LR., , Chakravarti   A., , Cho   JH., , Guttmacher   AE., , Kong   A., , Kruglyak   L., , Mardis   E., , Rotimi   CN., , Slatkin   M., , Valle   D., , Whittemore   AS., , Boehnke   M., , Clark   AG., , Eichler   EE., , Gibson   G., , Haines   JL., , Mackay   TF., , McCarroll   SA., , Visscher   PM. . Finding the missing heritability of complex diseases. . Nature . 2009; ;461: 7265 : 747– 753 .
    [Google Scholar]
  36. [36]. International HapMap Consortium., , Frazer   KA., , Ballinger   DG., , Cox   DR., , Hinds   DA., , Stuve   LL., , Gibbs   RA., , Belmont   JW., , Boudreau   A., , Hardenbol   P., , Leal   SM., , Pasternak   S., , Wheeler   DA., , Willis   TD., , Yu   F., , Yang   H., , Zeng   C., , Gao   Y., , Hu   H., , Hu   W., , Li   C., , Lin   W., , Liu   S., , Pan   H., , Tang   X., , Wang   J., , Wang   W., , Yu   J., , Zhang   B., , Zhang   Q., , Zhao   H., , Zhao   H., , Zhou   J., , Gabriel   SB., , Barry   R., , Blumenstiel   B., , Camargo   A., , Defelice   M., , Faggart   M., , Goyette   M., , Gupta   S., , Moore   J., , Nguyen   H., , Onofrio   RC., , Parkin   M., , Roy   J., , Stahl   E., , Winchester   E., , Ziaugra   L., , Altshuler   D., , Shen   Y., , Yao   Z., , Huang   W., , Chu   X., , He   Y., , Jin   L., , Liu   Y., , Shen   Y., , Sun   W., , Wang   H., , Wang   Y., , Wang   Y., , Xiong   X., , Xu   L., , Waye   MM., , Tsui   SK., , Xue   H., , Wong   JT., , Galver   LM., , Fan   JB., , Gunderson   K., , Murray   SS., , Oliphant   AR., , Chee   MS., , Montpetit   A., , Chagnon   F., , Ferretti   V., , Leboeuf   M., , Olivier   JF., , Phillips   MS., , Roumy   S., , Sallée   C., , Verner   A., , Hudson   TJ., , Kwok   PY., , Cai   D., , Koboldt   DC., , Miller   RD., , Pawlikowska   L., , Taillon-Miller   P., , Xiao   M., , Tsui   LC., , Mak   W., , Song   YQ., , Tam   PK., , Nakamura   Y., , Kawaguchi   T., , Kitamoto   T., , Morizono   T., , Nagashima   A., , Ohnishi   Y., , Sekine   A., , Tanaka   T., , Tsunoda   T., , Deloukas   P., , Bird   CP., , Delgado   M., , Dermitzakis   ET., , Gwilliam   R., , Hunt   S., , Morrison   J., , Powell   D., , Stranger   BE., , Whittaker   P., , Bentley   DR., , Daly   MJ., , de Bakker   PI., , Barrett   J., , Chretien   YR., , Maller   J., , McCarroll   S., , Patterson   N., , Pe'er   I., , Price   A., , Purcell   S., , Richter   DJ., , Sabeti   P., , Saxena   R., , Schaffner   SF., , Sham   PC., , Varilly   P., , Altshuler   D., , Stein   LD., , Krishnan   L., , Smith   AV., , Tello-Ruiz   MK., , Thorisson   GA., , Chakravarti   A., , Chen   PE., , Cutler   DJ., , Kashuk   CS., , Lin   S., , Abecasis   GR., , Guan   W., , Li   Y., , Munro   HM., , Qin   ZS., , Thomas   DJ., , McVean   G., , Auton   A., , Bottolo   L., , Cardin   N., , Eyheramendy   S., , Freeman   C., , Marchini   J., , Myers   S., , Spencer   C., , Stephens   M., , Donnelly   P., , Cardon   LR., , Clarke   G., , Evans   DM., , Morris   AP., , Weir   BS., , Tsunoda   T., , Mullikin   JC., , Sherry   ST., , Feolo   M., , Skol   A., , Zhang   H., , Zeng   C., , Zhao   H., , Matsuda   I., , Fukushima   Y., , Macer   DR., , Suda   E., , Rotimi   CN., , Adebamowo   CA., , Ajayi   I., , Aniagwu   T., , Marshall   PA., , Nkwodimmah   C., , Royal   CD., , Leppert   MF., , Dixon   M., , Peiffer   A., , Qiu   R., , Kent   A., , Kato   K., , Niikawa   N., , Adewole   IF., , Knoppers   BM., , Foster   MW., , Clayton   EW., , Watkin   J., , Gibbs   RA., , Belmont   JW., , Muzny   D., , Nazareth   L., , Sodergren   E., , Weinstock   GM., , Wheeler   DA., , Yakub   I., , Gabriel   SB., , Onofrio   RC., , Richter   DJ., , Ziaugra   L., , Birren   BW., , Daly   MJ., , Altshuler   D., , Wilson   RK., , Fulton   LL., , Rogers   J., , Burton   J., , Carter   NP., , Clee   CM., , Griffiths   M., , Jones   MC., , McLay   K., , Plumb   RW., , Ross   MT., , Sims   SK., , Willey   DL., , Chen   Z., , Han   H., , Kang   L., , Godbout   M., , Wallenburg   JC., , L'Archevêque   P., , Bellemare   G., , Saeki   K., , Wang   H., , An   D., , Fu   H., , Li   Q., , Wang   Z., , Wang   R., , Holden   AL., , Brooks   LD., , McEwen   JE., , Guyer   MS., , Wang   VO., , Peterson   JL., , Shi   M., , Spiegel   J., , Sung   LM., , Zacharia   LF., , Collins   FS., , Kennedy   K., , Jamieson   R., , Stewart   J. . A second generation human haplotype map of over 3.1 million SNPs. . Nature . 2007; ;449: 7164 : 851– 861 .
    [Google Scholar]
  37. [37]. Dhandapany   PS., , Sadayappan   S., , Xue   Y., , Powell   GT., , Rani   DS., , Nallari   P., , Rai   TS., , Khullar   M., , Soares   P., , Bahl   A., , Tharkan   JM., , Vaideeswar   P., , Rathinavel   A., , Narasimhan   C., , Ayapati   DR., , Ayub   Q., , Mehdi   SQ., , Oppenheimer   S., , Richards   MB., , Price   AL., , Patterson   N., , Reich   D., , Singh   L., , Tyler-Smith   C., , Thangaraj   K. . A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia. . Nat Genet . 2009; ;41: 2 : 187– 191 .
    [Google Scholar]
  38. [38]. Petronis   A. . Epigenetics as a unifying principle in the aetiology of complex traits and diseases. . Nature . 2010; ;465: 7299 : 721– 727 .
    [Google Scholar]
  39. [39]. United Nations Children's Fund and World Health Organization. Low Birth Weight: Country, Regional and Global Estimates. New York, UNICEF; 2004 .
  40. [40]. Roseboom   TJ., , van der Meulen   JH., , Osmond   C., , Barker   DJ., , Ravelli   AC., , Schroeder-Tanka   JM., , van Montfrans   GA., , Michels   RP., , Bleker   OP. . Coronary heart disease after prenatal exposure to the Dutch famine, 1944-45. . Heart . 2000; ;84: 6 : 595– 598 .
    [Google Scholar]
  41. [41]. Painter   RC., , de Rooij   SR., , Bossuyt   PM., , Simmers   TA., , Osmond   C., , Barker   DJ., , Bleker   OP., , Roseboom   TJ. . Early onset of coronary artery disease after prenatal exposure to the Dutch famine. . Am J Clin Nutr . 2006; ;84: 2 : 322– 327 .
    [Google Scholar]
  42. [42]. van Steijn   L., , Karamali   NS., , Kanhai   HH., , Ariëns   GA., , Fall   CH., , Yajnik   CS., , Middelkoop   BJ., , Tamsma   JT. . Neonatal anthropometry: thin-fat phenotype in fourth to fifth generation South Asian neonates in Surinam. . Int J Obes (Lond) . 2009; ;33: 11 : 1326– 1329 .
    [Google Scholar]
  43. [43]. Bictash   M., , Ebbels   TM., , Chan   Q., , Loo   RL., , Yap   IK., , Brown   IJ., , de Iorio   M., , Daviglus   ML., , Holmes   E., , Stamler   J., , Nicholson   JK., , Elliott   P. . Opening up the “Black Box”: metabolic phenotyping and metabolome-wide association studies in epidemiology. . J Clin Epidemiol . 2010; ;63: 9 : 970– 979 .
    [Google Scholar]
  44. [44]. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) . Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. . Circulation . 2002; ;106: 25 : 3143– 3421 .
    [Google Scholar]
  45. [45]. British Cardiac Society; British Hypertension Society; Diabetes UK; HEART UK; Primary Care Cardiovascular Society; Stroke Association . JBS 2: Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice. . Heart . 2005; ;   91 Suppl 5 : v1– 52 .
    [Google Scholar]
  46. [46]. Aarabi   M., , Jackson   PR. . Predicting coronary risk in UK South Asians: an adjustment method for Framingham-based tools. . Eur J Cardiovasc Prev Rehabil . 2005; ;12: 1 : 46– 51 .
    [Google Scholar]
  47. [47]. Hippisley-Cox   J., , Coupland   C., , Vinogradova   Y., , Robson   J., , Minhas   R., , Sheikh   A., , Brindle   P. . Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2. . BMJ . 2008; ;336: 7659 : 1475– 1482 .
    [Google Scholar]
  48. [48]. Hippisley-Cox   J., , Coupland   C., , Vinogradova   Y., , Robson   J., , Brindle   P. . Performance of the QRISK cardiovascular risk prediction algorithm in an independent UK sample of patients from general practice: a validation study. . Heart . 2008; ;94: 1 : 34– 39 .
    [Google Scholar]
  49. [49]. Collins   GS., , Altman   DG. . An independent and external validation of QRISK2 cardiovascular disease risk score: a prospective open cohort study. . BMJ . 2010; ;340: : c2442 .
    [Google Scholar]
  50. [50]. Balarajan   Y., , Selvaraj   S., , Subramanian   SV. . Health care and equity in India. . Lancet . 2011; ;377: 9764 : 505– 515 .
    [Google Scholar]
  51. [51]. Xavier   D., , Pais   P., , Devereaux   PJ., , Xie   C., , Prabhakaran   D., , Reddy   KS., , Gupta   R., , Joshi   P., , Kerkar   P., , Thanikachalam   S., , Haridas   KK., , Jaison   TM., , Naik   S., , Maity   AK., , Yusuf   S., , CREATE registry investigators. . Treatment and outcomes of acute coronary syndromes in India (CREATE): a prospective analysis of registry data. . Lancet . 2008; ;371: 9622 : 1435– 1442 .
    [Google Scholar]
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  • Article Type: Review Article
Keyword(s): Coronary heart disease , epigenome , genome , GWAS , Indian Asian , LOLIPOP and metabolome
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