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Volume 2014, Issue 4
  • ISSN: 2305-7823
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Abstract

The reason why some individuals but not others are susceptible to rheumatic fever and chronic rheumatic heart disease is not understood. Because of the substantial evidence that poverty is an important determinant of the disease and must operate in early life, we have investigated the role of the early environment in an ecological study using 20th century mortality as an index of disease prevalence. We analysed 37,321 deaths from rheumatic heart disease in England and Wales during 1968–78. We compared the geographical distribution of deaths with previous infant mortality records from 1911 onwards. These records included details of mortality at different ages and from different causes. They also included data on housing and population density. Mortality from rheumatic heart disease showed a strong correlation with past infant mortality that was consistently stronger with postneonatal mortality (deaths from one month to one year) than with neonatal mortality (deaths during the first month of life). Areas with high infant mortality from diarrhoea or bronchitis had the highest subsequent mortality from rheumatic heart disease. Although rheumatic heart disease was linked with early overcrowding, regression analyses suggested that overcrowding could not explain the infant mortality associations. Chronic rheumatic heart disease may have its origins in early infancy. Our findings raise the possibility that susceptibility to rheumatic fever and rheumatic heart disease may be linked with infection in the postneonatal period. Alternatively, they may be explained by the operation of environmental factors that both predispose to infection in infancy and the subsequent liability to heart disease.

© 2014 Phillips, Osmond, licensee Bloomsbury Qatar Foundation Journals.
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2015-02-01
2024-04-16
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References

  1. Lichtwitz L. Pathology and Therapy of Rheumatic Fever. New York: Grune & Stratton 1943.
     [Google Scholar]
  2. Seckeler MD, Hoke TR. The worldwide epidemiology of acute rheumatic fever and rheumatic heart disease. Clin Epidemiol. 2011; 3::67–84.
     [Google Scholar]
  3. Steer AC, Carapetis JR, Nolan TM, Shann F. Systematic review of rheumatic heart disease prevalence in children in developing countries: The role of environmental factors. J Paediatr Child Health. 2002; 38:3:229–234.
     [Google Scholar]
  4. Glover JA. Incidence of rheumatic diseases. Lancet. 1930; i::499–505.
     [Google Scholar]
  5. Longo-Mbenza B, Bayekula M, Ngiyulu R, Kintoki VE, Bikangi NF, Seghers KV, Lukoki LE, Mandundu MF, Manzanza M, Nlandu Y. Survey of rheumatic heart disease in school children of Kinshasa town. Int J Cardiol. 1998; 63:3:287–294.
     [Google Scholar]
  6. Bateson P, Barker D, Clutton-Brock T, Deb D, D'Udine B, Foley RA, Gluckman P, Godfrey K, Kirkwood T, Lahr MM, McNamara J, Metcalfe NB, Monaghan P, Spencer HG, Sultan SE. Developmental plasticity and human health. Nature. 2004; 430::419–421.
     [Google Scholar]
  7. Barker DJP. The Wellcome Foundation Lecture, 1994. The fetal origins of adult disease. Proc Roy Soc Lond. 1995; 262::37–43.
     [Google Scholar]
  8. Olgunturk R, Okur I, Cirak MY, Oguz AD, Akalin N, Turet S, Tunaoglu S. The role of viral agents in aetiopathogenesis of acute rheumatic fever. Clin Rheumatol. 2011; 30:1:15–20.
     [Google Scholar]
  9. Kumar RK, Tandon R. Rheumatic fever & rheumatic heart disease: The last 50 years. Indian J Med Res. 2013; 137:4:643–658.
     [Google Scholar]
  10. Eriksson JG, Kajantie E, Phillips DIW, Osmond C, Thornburg K, Barker DJ. The developmental origins of chronic rheumatic heart disease. Am J Human Biol. 2013; 25::655–658.
     [Google Scholar]
  11. Goodman A, Kajantie E, Osmond C, Eriksson J, Koupil I, Thornburg K, Phillips DI. The relationship between umbilical cord length and chronic rheumatic heart disease: A prospective cohort study. Eur J Prev Cardiol. 2014.
     [Google Scholar]
  12. Barker DJ, Osmond C, Law CM. The intrauterine and early postnatal origins of cardiovascular disease and chronic bronchitis. J Epidemiol Community Health. 1989; 43:3:237–240.
     [Google Scholar]
  13. Barker DJ, Osmond C. Childhood respiratory infection and adult chronic bronchitis in England and Wales. Br Med J (Clin Res Ed). 1986; 293:6557:1271–1275.
     [Google Scholar]
  14. Woolf B. Studies on infant mortality: Social aetiology of stillbirths and infant deaths in county boroughs of England and Wales. Br J Soc Med. 1947; 1:2:73–125.
     [Google Scholar]
  15. Carapetis JR. Rheumatic heart disease in Asia. Circulation. 2008; 118:25:2748–2753.
     [Google Scholar]
  16. Quinn RW, Sprague HA, Quinn JP. Mortality rates for rheumatic fever and rheumatic heart disease, 1940-65. Public Health Rep. 1970; 85:12:1091–1101.
     [Google Scholar]
  17. Pooley CG, Turnbull J. Migration trends in British rural areas from the 18th to the 20th centuries. Int J Popul Geogr. 1996; 2:3:215–237.
     [Google Scholar]
  18. Osmond C, Barker DJ, Slattery JM. Risk of death from cardiovascular disease and chronic bronchitis determined by place of birth in England and Wales. J Epidemiol Community Health. 1990; 44:2:139–141.
     [Google Scholar]
  19. Charakida M, Donald AE, Terese M, Leary S, Halcox JP, Ness A, Davey Smith G, Golding J, Friberg P, Klein NJ, Deanfield JE, ALSPAC (Avon Longitudinal Study of Parents and Children) Study Team . Endothelial dysfunction in childhood infection. Circulation. 2005; 111:13:1660–1665.
     [Google Scholar]
  20. Tandon R, Sharma M, Chandrashekhar Y, Kotb M, Yacoub MH, Narula J. Revisiting the pathogenesis of rheumatic fever and carditis. Nat Rev Cardiol. 2013; 10:3:171–177.
     [Google Scholar]
  21. Leeder SR, Corkhill R, Irwig LM, Holland WW, Colley JR. Influence of family factors on the incidence of lower respiratory illness during the first year of life. Br J Prev Soc Med. 1976; 30:4:203–212.
     [Google Scholar]
  22. Backes CH, Nelin T, Gorr MW, Wold LE. Early life exposure to air pollution: How bad is it? Toxicol Lett. 2013; 216:1:47–53.
     [Google Scholar]
  23. Pichichero ME. Group A beta-hemolytic streptococcal infections. Pediatr Rev. 1998; 19:9:291–302.
     [Google Scholar]
  24. Wannamaker LW. The epidemiology of streptococcal infections. In: McCarty M, ed. Streptococcal Infections. New York: Columbia University Press 1954.
     [Google Scholar]
  25. Glinianaia SV, Rankin J, Bell R, Pless-Mulloli T, Howel D. Does particulate air pollution contribute to infant death? A systematic review. Environ Health Perspect. 2004; 112:14:1365–1371.
     [Google Scholar]
  26. Ritz SA. Air pollution as a potential contributor to the ‘epidemic’ of autoimmune disease. Med Hypotheses. 2010; 74:1:110–117.
     [Google Scholar]
  27. Gardner MJ, Winter PD, Barker DJP. Atlas of Mortality from Selected Diseases. Chichester: John Wiley & Sons 1984.
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5339/gcsp.2014.59
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Is susceptibility to chronic rheumatic heart disease determined in early infancy? An analysis of mortality in Britain during the 20th century
Global Cardiology Science and Practice 2014, 59 (2015); https://doi.org/10.5339/gcsp.2014.59
/content/journals/10.5339/gcsp.2014.59
/content/journals/10.5339/gcsp.2014.59
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  • Article Type: Research Article
Keyword(s): Chronic Rheumatic Heart disease, infant mortality and postneonatal mortality
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