1887
Volume 2013, Issue 4
  • ISSN: 2305-7823
  • E-ISSN:

Abstract

The recent increase in human lifespan, coupled with unhealthy diets and lifestyles have led to an unprecedented increase in cardiovascular diseases. Even in the presence of a wide range of therapeutic options with variable efficacy, mortality due to heart failure is still high and there is a need to identify new therapeutic targets. Genetic and studies have implicated the Notch signalling in the development and maintenance of the cardiovascular system through a direct effect on biological functions of vascular cells (endothelial and vascular smooth muscle cells) and cardiomyocytes. Notch signalling is also involved in the modulation of inflammation, which plays a major role in causing and exacerbating cardiovascular diseases. The Notch pathway could represent a new therapeutic target for the treatment of cardiovascular diseases.

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2014-01-01
2019-12-14
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  • Article Type: Review Article
Keyword(s): apoptosis , atherosclerosis , cardiomyocytes , cardiotoxicity , endothelial cells and heart failure
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