1887
Volume 2013, Issue 3
  • ISSN: 2305-7823
  • EISSN:

Abstract

Ventricular arrhythmias in young people most commonly occur due to the presence of hypertrophic cardiomyopathy, long QT syndrome or Wolff-Parkinson-White syndrome. We present a case in which the patient had exercise induced syncopal spells and was found to have ventricular tachycardia (VT) during both exercise stress testing and an electrophysiology study. Further genetic studies showed a previously unseen desmosomal gene mutation confirming the presence of Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC).

Loading

Article metrics loading...

/content/journals/10.5339/gcsp.2013.33
2014-01-01
2020-10-25
Loading full text...

Full text loading...

/deliver/fulltext/gcsp/2013/3/gcsp.2013.33.html?itemId=/content/journals/10.5339/gcsp.2013.33&mimeType=html&fmt=ahah

References

  1. Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MG, Daubert JP, Fontaine G, Gear K, Hauer R, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DM, Steinberg JS, Tandri H, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba W. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria. EurHeart J. 2010; 31::806814.
    [Google Scholar]
  2. Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G. Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol. 2003; 42::19591963.
    [Google Scholar]
  3. James CA, Bhonsale A, Tichnell C, Murray B, Russell SD, Tandri H, Tedford RJ, Judge DP, Calkins H. Exercise increases age-related penetrance and arrhythmic risk in arrhythmogenic right ventricular dysplasia/cardiomyopathy-associated desmosmal mutation carriers. J Am Coll Cardiol. 2013; 62:14:12901297.
    [Google Scholar]
  4. Maron BJ, Zipes DP, et al., 36th Bethesda Conference:eligibility recommendations for competitive athletes with cardiovascular abnormalities. J Am Coll Cardiol. 2005; 45:8:13181321.
    [Google Scholar]
  5. Maron BJ, Ackerman MJ, Nishimura RA, Pyeritz RE, Towbin JA, Udelson JE. Task Force 4: HCM and other cardiomyopathies, mitral valve prolapse, myocarditis, and marfan syndrome. J Am Coll Cardiol. 2005; 45:8:13401345.
    [Google Scholar]
  6. Yoerger DM, Marcus F, Sherrill D, Calkins H, Towbin JA, Zareba W, Picard MH, Multidisciplinary Study of Right Ventricular Dysplasia Investigators . Echocardiographic findings in patients meeting task force criteria for arrhythmogenic right ventricular dysplasia: new insights from the multidisciplinary study of right ventricular dysplasia. J Am Coll Cardiol. 2005; 45:6:860865.
    [Google Scholar]
  7. Kottarthil J, Panuganti P, Jain A, Dalal D, Russell SD, Judge D, Calkins H, Tandri H. Role of Exercise Stress Testing in Arrhythmogenic Right Ventricular Dysplasia. Circulation. 2010; 122::A12355.
    [Google Scholar]
  8. Tandri H, Castillo E, Ferrari VA, Nasir K, Dalal D, Bomma C, Calkins H, Bluemke DA. Magnetic resonance imaging of arrhythmogenic right ventricular dysplasia;: sensitivity, specificity, and observer variability of fat detection versus functional analysis of the right ventricle. J Am Coll Cardiol. 2006; 48:11:22772284.
    [Google Scholar]
  9. Tandri H, Asimaki A, Abraham T, Dalal D, Tops L, Jain R, Saffitz JE, Judge DP, Russell SD, Halushka M, Bluemke DA, Kass DA, Calkins H. Prolonged RV endocardial activation duration: a novel marker of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Heart Rhythm. 2009 June; 6:6:769775.
    [Google Scholar]
  10. ElMaghawry M, Migliore F, Mohammed N, Sanoudou D, Alhashe M. Science and practice of arrhythmogenic cardiomyopathy: a paradigm shift. GCSP. 2013;8. http://dx.doi.org/10.5339/gcsp.2013.8 .
    [Google Scholar]
  11. Gerull B, Heuser A, Wichter T, Paul M, Basson CT, McDermott DA, Lerman BB, Markowitz SM. Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Nat Genet. 2004 Nov; 36:11:11621164, Epub 2004 Oct 17. Erratum in: Nat Genet. 2005 Jan;37(1):106.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.5339/gcsp.2013.33
Loading
/content/journals/10.5339/gcsp.2013.33
Loading

Data & Media loading...

Supplements

Supplementary File 1

  • Article Type: Research Article
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error