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Abstract

Abstract

Our objective was: Does Melatonin protect against cisplatin (Pt(II)) toxicity by a mechanism that is not free radical based? We used, flow cytometry, cell-viability, immunoblotting, and immunofluorescence, to determine the following: Cisplatin induced apoptosis is reversed by melatonin at physiological concentrations by localization of Bcl-2 and down regulation of Bax, besides reduction of oxidative stress.

Vignesh Shanmugam*, Amro Wafi, Elizabeth Varghese and Dietrich Büsselberg, Weill Cornell Medical College in Qatar

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/content/papers/10.5339/qproc.2012.mutagens.3.76
2012-03-01
2019-08-17
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http://instance.metastore.ingenta.com/content/papers/10.5339/qproc.2012.mutagens.3.76
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  • Received: 15 May 2012
  • Accepted: 15 May 2012
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