oa Sulfotransferase 1A1 (G638A) Gene Polymorphism in Sudanese Patients with Oesophageal Cancer

Sulfonate conjugation is an important phase II reaction in the biotransformation. SULT1A1 enzyme appears to be the principle human sulfotransferase involved in the elimination of most phenolic xenobiotics as well as bioactivation of several procarcinogens. Studies have demonstrated a large individual variation in the activity of SULT1A1, an individuals homozygotes for the SULT1A1*2 allele had only about 15 percent of the SULT activity and it may has the potential to influence individual susceptibility to chemical carcinogensis. The purpose of this hospital-based case control study was to evaluate whether SULT1A1 (G638A) polymorphism causes Arg213His amino acid change is a risk factor for oesophageal cancer in Sudan. A total of 112 patients and 194 healthy controls were included. Lifestyle information and detailed smoking histories were obtained. Genomic DNA was isolated from peripheral blood lymphocytes and genotyping was performed using PCR/RFLP analysis. Our finding showed that the frequency of the SULT1A1*2 (His) allele was 17.9 percent in cases and 14.9 percent in controls. Multivariant logistic regression analysis showed no significant association between SULT1A1*2/*2 genotype and oesophageal cancer risk (OR=3.7, P= 3.7, CI= 0.33 - 41.5). We concluded that SULT1A1 (G638A) polymorphism is not a risk factor for oesophageal cancer in Sudan.

H. B. Eltahir, C. Dandara, M. I. Parker, M. E. Ahmed, S. S. Fedail, A.O.Mohamed .