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oa An Alternative Mechanism for Melatonin’s Protective Effects on Metal Ion Toxicity – Modulation of pro-/anti-apoptotic Proteins
- Publisher: Hamad bin Khalifa University Press (HBKU Press)
- Source: QScience Proceedings, Sixth International Conference on Environmental Mutagens in Human Populations, Mar 2012, Volume 2012, 76
Abstract
Abstract
Our objective was: Does Melatonin protect against cisplatin (Pt(II)) toxicity by a mechanism that is not free radical based? We used, flow cytometry, cell-viability, immunoblotting, and immunofluorescence, to determine the following: Cisplatin induced apoptosis is reversed by melatonin at physiological concentrations by localization of Bcl-2 and down regulation of Bax, besides reduction of oxidative stress.
Vignesh Shanmugam*, Amro Wafi, Elizabeth Varghese and Dietrich Büsselberg, Weill Cornell Medical College in Qatar
© 2012 Shanmugam, licensee
Bloomsbury Qatar Foundation Journals.
- 15 May 2012
- 15 May 2012