oa Associations of adipocytokines and anthropometric measurements of the newborns of pregnant women with abnormal screening of 50g glucose tolerance test in State of Qatar

Adipose tissue secretes several adipocytokines that may play an important role in development of insulin resistance during pregnancy. The aim of this study is to investigate the associations of these adipocytokines with anthropometric measurements of the newborns of pregnant women with abnormal 50g glucose tolerance test [GTT] results.

The study subjects included all pregnant women (n=85) of matched age and BMI, that showed abnormal results to 50g [GTT]. During 100g [GTT], fasting blood samples were analyzed for glucose, lipid profile, IL-6, TNF-α, Hs-CRP, insulin, and total adiponectin.

100g [GTT] showed that 60% were normal [C] and 40 % had impaired glucose tolerance [IGTT]. Of all biochemical measured, only glucose (fasting, 1h, 2h, and 3h) and insulin were significantly higher in [IGTT] group than [C] group. Mean values ±SD; Il-6 (2.56±1.16 vs. 2.49±1.63 pg/ml, p=0.80), TNF-α (3.86±2.52 vs. 5.16±3.45 pg/ml, p=0.07), Hs-CRP (48.59±17.03 vs. 50.18±18.19 ng/ml, p=0.69), and total adiponectin (15.97±8.09 vs. 14.65±7.15 μg/ml, p=0.31) among [C] and [IGTT], respectively. No significant differences were observed for anthropometric measurements studied such as birth weight (3209.66±463.57 vs. 3558.50±80.66 g, p=0.74), placenta weight [PW], ponderal index [PI] and birth weight/placental weight index [FPI] between [C] and [IGTT] groups, respectively. TNF-α was positively correlated significantly with Il-6 (r=0.29, P=0.012), PW (r=0.48, P=0.017) and negatively with FPI (r= -0.47, P=0.019), gestational age ”GA”(r=-0.41, P=-0.043) and total adiponectin (r=-0.28, P=0.016).

Marked hyperglycemia and hyperinsulinemia were observed in IGTT. Of all adipokines measured, TNF-α had a significant relationship with PW, FPI, and GA.