oa Effects Of Gestational Diabetes Mellitus On Hematopoietic Stem cell quality and IL6 Amount

Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy (1), Maternal glucose and lipid metabolism changes substantially during normal pregnancy, In women with GDM, fasting insulin and fasting glucose concentrations are elevated. Also, women with GDM have a lower insulin sensitivity compared to controls and the difference is most evident before and during early pregnancy (2). Gestational diabetes mellitus has proven it»s effects on many variables of pregnancy and so it»s effect on umbilical cord blood (UCB), which is increasingly used as an alternative source of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) for bone marrow transplantation and other therapeutic uses, And for successful outcomes of cord blood transplantation certain criteria are used in UCB banks include the TNC count, percentage of CD34, CFU and the volume of blood (3) As many variables that may affect the quality of hematopoietic stem cells are still under study and research, And gestational diabetes mellitus is a disease expected to increase by 20 fold, AS regard it»s effect on hematopoietic stem cell and IL6 it»s found that «The proportion of CD34+ CD45 HSPCs among the nucleated cells was significantly higher in the cord blood samples of neonates born to mothers with GDM compared to neonates born to non-diabetic mothers.»(4) Also, it»s found that IL-6 concentrations are increased in women with current GDM (2). Another study reported that: the CD16+CD56 −  NK cells was increased, while IL-2 was lower in maternal blood with GDM. The placental extravillous layer of the gestational diabetic mothers showed high levels of IL-4, IL-6, IL-10, IL-17, and IFN- and low levels of IL-1 and IL8, whereas the placental villous layer contained high levels of IL-17 and IFN(5). In this study we provide atrial for knowing whether the cord blood unit of gestational diabetic mother fulfilling the appropiate criteria for banking, As in previous studies all what had discovered is minimal non concolusive data about whether GDM unit fulfilling the normal criteria for banking or not.