1887
Volume 2021, Issue 2
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

Background: Pain management is an evolving area of expertise in Qatar. Gaps in knowledge, inadequate training for physicians and nurses, and the absence of policies/guidelines are the main barriers to effective pain management in Qatar. In addition, the use of certain pain medication, especially opioids, is highly regulated, limiting their availability in outpatient pain management. These factors are responsible for the undertreatment of pain in Qatar. This study aimed to standardize evidence-based local recommendations for pharmacological treatment of pain in Qatar.

Methods: An expert panel of physicians from different disciplines, with experience in diagnosis and treatment of the three pain types (i.e., acute, chronic, and neuropathic), was convened for two face-to-face meetings in Doha, Qatar, on November 29, 2019, and on February 22, 2020, with subsequent virtual meetings. A literature search was performed on Medline and Google Scholar databases from inception till December 2019, and all relevant articles were selected. Based on these articles and repeated feedback from the authors, the final pain treatment protocols were developed.Results: Recommendations for the treatment of acute pain, based on pain severity, followed three approaches: acetaminophen/paracetamol or non-steroidal anti-inflammatory drugs (NSAIDs) for mild pain and moderate pain and referral to a pain specialist for severe pain. Acetaminophen/paracetamol or NSAIDs is recommended for chronic pain, and the use of opioids was strongly discouraged because of its long-term side effects. For neuropathic pain, tricyclic antidepressants or gabapentin or pregabalin or serotonin-norepinephrine reuptake inhibitors were recommended first-line agents. Non-responders must be referred to neurologists or a pain specialist.

Conclusion: The expert panel provides recommendations for the management of acute, chronic, and neuropathic pain based on international guidelines adapted to local practice and treatment availability in Qatar. More importantly, the panel has recommended taking extreme caution in the use of opioids for long-term management of chronic pain and to refer the patient to a pain specialist clinician as required.

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2021-07-07
2024-03-28
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References

  1. Tompkins DA, Hobelmann JG, Compton P. Providing chronic pain management in the “Fifth Vital Sign” Era: Historical and treatment perspectives on a modern-day medical dilemma. Drug Alcohol Depend. 2017;volume>173 Suppl 1(Suppl 1):S11–S21.
    [Google Scholar]
  2. Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, et al. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020; 161:(9):1976–82.
    [Google Scholar]
  3. Orr PM, Shank BC, Black AC. The role of pain classification systems in pain management. Crit Care Nurs Clin North Am. 2017; 29:(4):407–18.
    [Google Scholar]
  4. Keating L, Smith S. Acute pain in the emergency department: The challenges. Rev Pain. 2011; 5:(3):13–7.
    [Google Scholar]
  5. Wu A, March L, Zheng X, Huang J, Wang X, Zhao J, et al. Global low back pain prevalence and years lived with disability from 1990 to 2017: estimates from the Global Burden of Disease Study 2017. Ann Transl Med. 2020; 8:(6):299.
    [Google Scholar]
  6. Bener A, Dafeeah EE, Alnaqbi K, Falah O, Aljuhaisi T, Sadeeq A, et al. An epidemiologic analysis of low back pain in primary care: a hot humid country and global comparison. J Prim Care Community Health. 2013; 4:(3):2207.
    [Google Scholar]
  7. Abolfotouh SM, Mahmoud K, Faraj K, Moammer G, ElSayed A, Abolfotouh MA. Prevalence, consequences and predictors of low back pain among nurses in a tertiary care setting. Int Orthop. 2015; 39:(12):2439–49.
    [Google Scholar]
  8. White LD, Hodge A, Vlok R, Hurtado G, Eastern K, Melhuish TM. Efficacy and adverse effects of buprenorphine in acute pain management: systematic review and meta-analysis of randomised controlled trials. Br J Anaesth. 2018; 120:(4):668–78.
    [Google Scholar]
  9. Albrecht E, Taffe P, Yersin B, Schoettker P, Decosterd I, Hugli O. Undertreatment of acute pain (oligoanalgesia) and medical practice variation in prehospital analgesia of adult trauma patients: a 10 yr retrospective study. Br J Anaesth. 2013; 110:(1):96–106.
    [Google Scholar]
  10. Motov SM, Khan AN. Problems and barriers of pain management in the emergency department: Are we ever going to get better? J Pain Res. 2008;2:5–11.
    [Google Scholar]
  11. Motov SM, Nelson LS. Advanced concepts and controversies in emergency department pain management. Anesthesiol Clin. 2016; 34:(2):271–85.
    [Google Scholar]
  12. Foster NE, Mullis R, Hill JC, Lewis M, Whitehurst DG, Doyle C, et al. Effect of stratified care for low back pain in family practice (IMPaCT Back): a prospective population-based sequential comparison. Ann Fam Med. 2014; 12:(2):102–11.
    [Google Scholar]
  13. Ayad AE, Ghaly N, Ragab R, Majeed S, Nassar H, Al Jalabi. A, et al. Expert panel consensus recommendations for the pharmacological treatment of acute pain in the Middle East region. J Int Med Res. 2011; 39:(4):1123–41.
    [Google Scholar]
  14. Bouri F, El Ansari. W, Mahmoud S, Elhessy A, Al-Ansari A, Al-Dosari MAA. Orthopedic professionals’ recognition and knowledge of pain and perceived barriers to optimal pain management at five hospitals. Healthcare (Basel). 2018; 6:(3).
    [Google Scholar]
  15. Bohlega S, Alsaadi T, Amir A, Hosny H, Karawagh AM, Moulin D, et al. Guidelines for the pharmacological treatment of peripheral neuropathic pain: expert panel recommendations for the middle East region. J Int Med Res. 2010; 38:(2):295–317.
    [Google Scholar]
  16. Acute Pain Management in Emergency and Acute Care Settings [Internet]. Pain Management and Assessment Initiative (PAMI): A Patient Safety Project. 2016.
  17. Breivik H, Borchgrevink PC, Allen SM, Rosseland LA, Romundstad L, Hals EK, et al. Assessment of pain. Br J Anaesth. 2008; 101:(1):17–24.
    [Google Scholar]
  18. Tsze DS, Pan SS, DePeter KC, Wagh AM, Gordon SL, Dayan PS. Intranasal hydromorphone for treatment of acute pain in children: A pilot study. Am J Emerg Med. 2019; 37:(6):1128–32.
    [Google Scholar]
  19. Colberg SR, Sigal RJ, Yardley JE, Riddell MC, Dunstan DW, Dempsey PC, et al. Physical activity/exercise and diabetes: A position statement of the American diabetes association. Diabetes Care. 2016; 39:(11):2065–79.
    [Google Scholar]
  20. Sharma CV. Paracetamol: mechanisums and udpates.continuing education in anaesthesia critical care & cain. 2014; 14:(4):153–8.
    [Google Scholar]
  21. Shiffman S, Battista DR, Kelly JP, Malone MK, Weinstein RB, Kaufman DW. Prevalence of exceeding maximum daily dose of paracetamol, and seasonal variations in cold-flu season. Br J Clin Pharmacol. 2018; 84:(6):1250–7.
    [Google Scholar]
  22. Lyrtzis C, Natsis K, Papadopoulos C, Noussios G, Papathanasiou E. Efficacy of paracetamol versus diclofenac for Grade II ankle sprains. Foot Ankle Int. 2011; 32:(6):571–5.
    [Google Scholar]
  23. Bondarsky EE, Domingo AT, Matuza NM, Taylor MB, Thode HC Jr., Singer AJ. Ibuprofen vs acetaminophen vs their combination in the relief of musculoskeletal pain in the ED: a randomized, controlled trial. Am J Emerg Med. 2013; 31:(9):1357–60.
    [Google Scholar]
  24. Buccelletti F, Marsiliani D, Zuccalà G, Iacomini P, Proietti L, Pola E, et al. Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department. Eur Rev Med Pharmacol Sci. 2014; 18:(20):3139–43.
    [Google Scholar]
  25. Ridderikhof ML, Lirk P, Goddijn H, Vandewalle E, Schinkel E, Van Dieren. S, et al. Acetaminophen or nonsteroidal anti-inflammatory drugs in acute musculoskeletal trauma: A multicenter, double-blind, randomized, clinical trial. Ann Emerg Med. 2018; 71:(3):357–68 e8.
    [Google Scholar]
  26. Oyler DR, Parli SE, Bernard AC, Chang PK, Procter LD, Harned ME. Nonopioid management of acute pain associated with trauma: Focus on pharmacologic options. J Trauma Acute Care Surg. 2015; 79:(3):475–83.
    [Google Scholar]
  27. Jahr JS, Filocamo P, Singh S. Intravenous acetaminophen: a review of pharmacoeconomic science for perioperative use. Am J Ther. 2013; 20:(2):189–99.
    [Google Scholar]
  28. Apfel CC, Turan A, Souza K, Pergolizzi J, Hornuss C. Intravenous acetaminophen reduces postoperative nausea and vomiting: a systematic review and meta-analysis. Pain. 2013; 154:(5):677–89.
    [Google Scholar]
  29. Blanco JS, Perlman SL, Cha HS, Delpizzo K. Multimodal pain management after spinal surgery for adolescent idiopathic scoliosis. Orthopedics. 2013; 36:(2 Suppl):33–5.
    [Google Scholar]
  30. Tsang KS, Page J, Mackenney P. Can intravenous paracetamol reduce opioid use in preoperative hip fracture patients? Orthopedics. 2013; 36:(2 Suppl):20–4.
    [Google Scholar]
  31. Lachiewicz PF. The role of intravenous acetaminophen in multimodal pain protocols for perioperative orthopedic patients. Orthopedics. 2013; 36:(2 Suppl):15–9.
    [Google Scholar]
  32. Ceelie I, de Wildt. SN, van Dijk M, van den Berg MM, van den Bosch GE, Duivenvoorden HJ, et al. Effect of intravenous paracetamol on postoperative morphine requirements in neonates and infants undergoing major noncardiac surgery: a randomized controlled trial. JAMA. 2013; 309:(2):149–54.
    [Google Scholar]
  33. Bektas F, Eken C, Karadeniz O, Goksu E, Cubuk M, Cete Y. Intravenous paracetamol or morphine for the treatment of renal colic: a randomized, placebo-controlled trial. Ann Emerg Med. 2009; 54:(4):568–74.
    [Google Scholar]
  34. Serinken M, Eken C, Turkcuer I, Elicabuk H, Uyanik E, Schultz CH. Intravenous paracetamol versus morphine for renal colic in the emergency department: a randomised double-blind controlled trial. Emerg Med J. 2012; 29:(11):902–5.
    [Google Scholar]
  35. Azizkhani R, Pourafzali SM, Baloochestani E, Masoumi B. Comparing the analgesic effect of intravenous acetaminophen and morphine on patients with renal colic pain referring to the emergency department: A randomized controlled trial. J Res Med Sci. 2013; 18:(9):772–6.
    [Google Scholar]
  36. Masoumi K, Forouzan A, Asgari Darian. A, Feli M, Barzegari H, Khavanin A. Comparison of clinical efficacy of intravenous acetaminophen with intravenous morphine in acute renal colic: a randomized, double-blind, controlled trial. Emerg Med Int. 2014;2014:571326.
    [Google Scholar]
  37. Hartling L, Ali S, Dryden DM, Chordiya P, Johnson DW, Plint AC, et al. How safe are common analgesics for the treatment of acute pain for children? A systematic review. Pain Res Manag. 2016;2016:5346819.
    [Google Scholar]
  38. Moore N, Pollack C, Butkerait P. Adverse drug reactions and drug-drug interactions with over-the-counter NSAIDs. Ther Clin Risk Manag. 2015; 11::1061–75.
    [Google Scholar]
  39. Schink T, Kollhorst B, Varas Lorenzo. C, Arfè A, Herings R, Lucchi S, et al. Risk of ischemic stroke and the use of individual non-steroidal anti-inflammatory drugs: A multi-country European database study within the SOS Project. PLoS One. 2018; 13:(9):e0203362.
    [Google Scholar]
  40. Klein A, Eliakim R. Non steroidal anti-inflammatory drugs and inflammatory bowel disease. Pharmaceuticals (Basel). 2010; 3:(4):1084–92.
    [Google Scholar]
  41. Gimbel JS, Brugger A, Zhao W, Verburg KM, Geis GS. Efficacy and tolerability of celecoxib versus hydrocodone/acetaminophen in the treatment of pain after ambulatory orthopedic surgery in adults. Clin Ther. 2001; 23:(2):228–41.
    [Google Scholar]
  42. Friedman BW, Dym AA, Davitt M, Holden L, Solorzano C, Esses D, et al. Naproxen with cyclobenzaprine, oxycodone/acetaminophen, or placebo for treating acute low back pain: A randomized clinical trial. JAMA. 2015; 314:(15):1572–80.
    [Google Scholar]
  43. Pathan SA, Mitra B, Cameron PA. A systematic review and meta-analysis comparing the efficacy of nonsteroidal anti-inflammatory drugs, opioids, and paracetamol in the Treatment of Acute Renal Colic. Eur Urol. 2018; 73:(4):583–95.
    [Google Scholar]
  44. Pathan SA, Mitra B, Straney LD, Afzal MS, Anjum S, Shukla D, et al. Delivering safe and effective analgesia for management of renal colic in the emergency department: a double-blind, multigroup, randomised controlled trial. Lancet. 2016; 387:(10032):1999–2007.
    [Google Scholar]
  45. Qureshi I, Pathan SA, Qureshi RS, Thomas SH. Intramuscular versus oral diclofenac for acute pain in adults with acute musculoskeletal injuries presenting to the ED setting: a prospective, double-blind, double-dummy, randomised controlled trial. Emerg Med J. 2019; 36:(7):401–6.
    [Google Scholar]
  46. Ortiz MI, Monroy-Maya R Fau - Soto-Ríos M, Soto-Ríos M Fau - Carrillo-Alarcón LC, et al. Effectiveness of diclofenac, ketorolac and etoricoxib in the treatment of acute pain from ankle fracture. Proc West Pharmacol Soc. 2010;53:46–8.
    [Google Scholar]
  47. Wright JM, Price SD, Watson WA. NSAID use and efficacy in the emergency department: single doses of oral ibuprofen versus intramuscular ketorolac. Ann Pharmacother. 1994; 28:(3):309-12.
    [Google Scholar]
  48. Turturro MA, Paris PM, Seaberg DC. Intramuscular ketorolac versus oral ibuprofen in acute musculoskeletal pain. Ann Emerg Med. 1995; 26:(2):117–20.
    [Google Scholar]
  49. Plapler PG, Scheinberg MA, Ecclissato Cda. C, Bocchi de Oliveira MF, Amazonas RB. Double-blind, randomized, double-dummy clinical trial comparing the efficacy of ketorolac trometamol and naproxen for acute low back pain. Drug Des Devel Ther. 2016;10:1987–93.
    [Google Scholar]
  50. Motov S, Yasavolian M, Likourezos A, Pushkar I, Hossain R, Drapkin J, et al. Comparison of intravenous ketorolac at three single-dose regimens for treating acute pain in the emergency department: A randomized controlled trial. Ann Emerg Med. 2017; 70:(2):177–84.
    [Google Scholar]
  51. Baharuddin KA, Rahman NH, Wahab SF, Halim NA, Ahmad R. Intravenous parecoxib sodium as an analgesic alternative to morphine in acute trauma pain in the emergency department. Int J Emerg Med. 2014; 7:(1):2.
    [Google Scholar]
  52. Lloyd R, Derry S, Moore RA, McQuay HJ. Intravenous or intramuscular parecoxib for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009; 2009:(2):CD004771.
    [Google Scholar]
  53. Derry S, Wiffen PJ, Aldington D, Moore RA. Nortriptyline for neuropathic pain in adults. Cochrane Database Syst Rev. 2015; 1:(1):CD011209.
    [Google Scholar]
  54. Baraf HS, Gloth FM, Barthel HR, Gold MS, Altman RD. Safety and efficacy of topical diclofenac sodium gel for knee osteoarthritis in elderly and younger patients: pooled data from three randomized, double-blind, parallel-group, placebo-controlled, multicentre trials. Drugs Aging. 2011; 28:(1):27–40.
    [Google Scholar]
  55. Bariguian Revel F, Fayet M, Hagen M. Topical diclofenac, an efficacious treatment for osteoarthritis: A narrative review. Rheumatol Ther. 2020; 7:(2):217–36.
    [Google Scholar]
  56. Oguzturk H, Ozgur D, Turtay MG, Kayaalp C, Yilmaz S, Dogan M, et al. Tramadol or paracetamol do not effect the diagnostic accuracy of acute abdominal pain with significant pain relief - a prospective, randomized, placebo controlled double blind study. Eur Rev Med Pharmacol Sci. 2012; 16:(14):1983–8.
    [Google Scholar]
  57. Mortelmans LJ, Desruelles D, Baert JA, Hente KR, Tailly GG. Use of tramadol drip in controlling renal colic pain. J Endourol. 2006; 20:(12):1010–5.
    [Google Scholar]
  58. Engindeniz Z, Demircan C, Karli N, Armagan E, Bulut M, Aydin T, et al. Intramuscular tramadol vs. diclofenac sodium for the treatment of acute migraine attacks in emergency department: a prospective, randomised, double-blind study. J Headache Pain. 2005; 6:(3):143–8.
    [Google Scholar]
  59. Park YB, Ha CW, Cho SD, Lee MC, Lee JH, Seo SS, et al. A randomized study to compare the efficacy and safety of extended-release and immediate-release tramadol HCl/acetaminophen in patients with acute pain following total knee replacement. Curr Med Res Opin. 2015; 31:(1):75–84.
    [Google Scholar]
  60. Bugada D, Lavand'homme P, Ambrosoli AL, Klersy C, Braschi A, Fanelli G, et al. Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study. J Clin Anesth. 2015; 27:(8):658–64.
    [Google Scholar]
  61. Moore RA, McQuay HJ, Tomaszewski J, Raba G, Tutunaru D, Lietuviete N, et al. Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy. BMC Anesthesiol. 2016;16:9.
    [Google Scholar]
  62. Bouida W, Beltaief K, Msolli MA, Ben Marzouk. M, Boubaker H, Grissa MH, et al. Effect on Morphine Requirement of Early Administration of Oral Acetaminophen vs. Acetaminophen/Tramadol Combination in Acute Pain. Pain Pract. 2019; 19:(3):275–82.
    [Google Scholar]
  63. Zarghami M, Masoum B, Shiran MR, Lanier RK, Lofwall MR, Mintzer MZ, et al. Tramadol versus methadone for treatment of opiate withdrawal: a double-blind, randomized, clinical trial Physical dependence potential of daily tramadol dosing in humans. J Addict Dis. 2012; 31:(2):112–7.
    [Google Scholar]
  64. Lofwall MR, Walsh SL, Bigelow GE, Strain EC, Adams EH, Breiner S, et al. Modest opioid withdrawal suppression efficacy of oral tramadol in humans. Psychopharmacol (Berl). 2007; 194:(3):381–93.
    [Google Scholar]
  65. Dunn KE, Tompkins DA, Bigelow GE, Strain EC. Efficacy of Tramadol Extended-Release for Opioid Withdrawal: A Randomized Clinical Trial. JAMA Psychiatry. 2017; 74:(9):885–93.
    [Google Scholar]
  66. Das M, Jain R, Dhawan A, Kaur A, Lofwall MR, Babalonis S, et al. Assessment of abuse liability of Tramadol among experienced drug users: Double-blind crossover randomized controlled trial Efficacy of extended-release tramadol for treatment of prescription opioid withdrawal: a two-phase randomized controlled trial. J Opioid Manag. 2016; 12:(6):421–30.
    [Google Scholar]
  67. Lofwall MR, Babalonis S, Nuzzo PA, Siegel A, Campbell C, Walsh SL. Efficacy of extended-release tramadol for treatment of prescription opioid withdrawal: a two-phase randomized controlled trial. Drug Alcohol Depend. 2013; 133:(1):188–97.
    [Google Scholar]
  68. Lanier RK, Lofwall MR, Mintzer MZ, Bigelow GE, Strain EC. Physical dependence potential of daily tramadol dosing in humans. Psychopharmacology (Berl). 2010; 211:(4):457–66.
    [Google Scholar]
  69. Adams EH, Breiner S, Cicero TJ, Geller A, Inciardi JA, Schnoll SH, et al. A comparison of the abuse liability of tramadol, NSAIDs, and hydrocodone in patients with chronic pain. J Pain Symptom Manage. 2006; 31:(5):465–76.
    [Google Scholar]
  70. Knisely JS, Campbell ED, Dawson KS, Schnoll SH, Camí J, Lamas X, et al. Tramadol post-marketing surveillance in health care professionals. Drug Alcohol Depend. 2002; 68:(1):15–22.
    [Google Scholar]
  71. Camí J, Lamas X, Farré M, Preston KL, Jasinski DR, Testa M, et al. Acute effects of tramadol in methadone-maintained volunteers. Drugs. 1994; 47: Suppl 1(1):39–43.
    [Google Scholar]
  72. Preston KL, Jasinski DR, Testa M, Richter W, Barth H, Flohé L, et al. Abuse potential and pharmacological comparison of tramadol and morphine. Drug Alcohol Depend. 1991; 27:(1):7–17.
    [Google Scholar]
  73. Richter W, Barth H, Flohé L, Giertz H. Clinical investigation on the development of dependence during oral therapy with tramadol. Arzneimittelforschung. 1985; 35:(11):1742–4.
    [Google Scholar]
  74. Chidambaran V, Sadhasivam S, Mahmoud M. Codeine and opioid metabolism: implications and alternatives for pediatric pain management. Curr Opin Anaesthesiol. 2017; 30:(3):349–56.
    [Google Scholar]
  75. Shah A, Hayes CJ, Martin BC. Characteristics of initial prescription episodes and likelihood of long-term opioid use - United States, 2006–2015. MMWR Morb Mortal Wkly Rep. 2017; 66:(10):265–9.
    [Google Scholar]
  76. Dart RC, Surratt HL, Cicero TJ, Parrino MW, Severtson SG, Bucher-Bartelson B, et al. Trends in opioid analgesic abuse and mortality in the United States. N Engl J Med. 2015; 372:(3):241–8.
    [Google Scholar]
  77. Nasser SC, Nassif JG, Saad AH. Physicians’ attitudes to clinical pain management and education: Survey from a middle Eastern country. Pain Res Manag. 2016;2016:1358593.
    [Google Scholar]
  78. Motov S, Mann S, Drapkin J, Butt M, Likourezos A, Yetter E, et al. Intravenous subdissociative-dose ketamine versus morphine for acute geriatric pain in the Emergency Department: A randomized controlled trial. Am J Emerg Med. 2019; 37:(2):220–7.
    [Google Scholar]
  79. Karlow N, Schlaepfer CH, Stoll CRT, Doering M, Carpenter CR, Colditz GA, et al. A systematic review and meta-analysis of Ketamine as an alternative to opioids for acute pain in the emergency department. Acad Emerg Med. 2018; 25:(10):1086–97.
    [Google Scholar]
  80. Dinges HC, Otto S, Stay DK, Bäumlein S, Waldmann S, Kranke P, et al. Side effect rates of opioids in equianalgesic doses via intravenous patient-controlled analgesia: A systematic review and network meta-analysis. Anesth Analg. 2019; 129:(4):1153–62.
    [Google Scholar]
  81. Tan HP, Conroy T. The effectiveness of intravenous Oxycodone in the treatment of acute postoperative pain: A systematic review. J Perianesth Nurs. 2018; 33:(6):865–79.
    [Google Scholar]
  82. Miner JR, Melson TI, Leiman D, Minkowitz HS, Chiang YK, DiDonato KP, et al. Pooled Phase III safety analysis of sufentanil sublingual tablets for short-term treatment of moderate-to-severe acute pain. Pain Manag. 2019; 9:(3):259–71.
    [Google Scholar]
  83. Brinck EC, Tiippana E, Heesen M, Bell RF, Straube S, Moore RA, et al. Perioperative intravenous ketamine for acute postoperative pain in adults. Cochrane Database Syst Rev. 2018; 12:(12):CD012033.
    [Google Scholar]
  84. Sin B, Jeffrey I, Halpern Z, Adebayo A, Wing T, Lee AS, et al. Intranasal sufentanil versus intravenous morphine for acute pain in the emergency department: A randomized pilot trial. J Emerg Med. 2019; 56:(3):301–7.
    [Google Scholar]
  85. Chinn E, Friedman BW, Naeem F, Irizarry E, Afrifa F, Zias E, et al. Randomized Trial of Intravenous Lidocaine Versus Hydromorphone for Acute Abdominal Pain in the Emergency Department. Ann Emerg Med. 2019; 74:(2):233–40.
    [Google Scholar]
  86. Singla NK, Skobieranda F, Soergel DG, Salamea M, Burt DA, Demitrack MA, et al. APOLLO-2: A Randomized, Placebo and Active-Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein-Biased Ligand at the μ-Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty. Pain Pract. 2019; 19:(7):715–31.
    [Google Scholar]
  87. Blancher M, Maignan M, Clapé C, Quesada JL, Collomb-Muret R, Albasini F, et al. Intranasal sufentanil versus intravenous morphine for acute severe trauma pain: A double-blind randomized non-inferiority study. PLoS Med. 2019; 16:(7):e1002849.
    [Google Scholar]
  88. Raffaeli W, Arnaudo E. Pain as a disease: an overview. J Pain Res. 2017;10:2003–8.
    [Google Scholar]
  89. Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, et al. A classification of chronic pain for ICD-11. Pain. 2015; 156:(6):1003–7.
    [Google Scholar]
  90. American Pain Society. Pain: Current Understanding of Assessment, Management, and Treatments. [Available from: https://www.npcnow.org/system/files/research/download/Pain-Current-Understanding-of-Assessment-Management-and-Treatments.pdf.
  91. Human Rights Watch. Global State of Pain Treatment. 2011.
    [Google Scholar]
  92. Bates D, Schultheis BC, Hanes MC, Jolly SM, Chakravarthy KV, Deer TR, et al. A comprehensive algorithm for management of neuropathic pain. Pain Med. 2019; 20:(Suppl 1):S2–S12.
    [Google Scholar]
  93. Pelletier JP, Martel-Pelletier J, Rannou F, Cooper C. Efficacy and safety of oral NSAIDs and analgesics in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016; 45:(4 Suppl):S22–7.
    [Google Scholar]
  94. American Diabetes Association. 5. Lifestyle Management: Standards of Medical Care in Diabetes-2019. Diabetes Care. 2019; 42:(Suppl 1):S46–S60.
    [Google Scholar]
  95. Chou R, Deyo R, Friedly J, Skelly A, Weimer M, Fu R, et al. Systemic pharmacologic therapies for low back pain: A systematic review for an American college of physicians clinical practice guideline. Ann Intern Med. 2017; 166:(7):480–92.
    [Google Scholar]
  96. Enthoven WT, Roelofs PD, Deyo RA, van Tulder. MW, Koes BW. Non-steroidal anti-inflammatory drugs for chronic low back pain. Cochrane Database Syst Rev. 2016; 2:(2):CD012087.
    [Google Scholar]
  97. Roelofs PD, Deyo RA, Koes BW, Scholten RJ, van Tulder. MW. Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database Syst Rev. 2008(1):CD000396.
    [Google Scholar]
  98. Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, et al. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet. 2013; 382:(9894):769–79.
    [Google Scholar]
  99. Davies RA, Maher CG, Hancock MJ. A systematic review of paracetamol for non-specific low back pain. Eur Spine J. 2008; 17:(11):1423–30.
    [Google Scholar]
  100. Doherty M, Hawkey C, Goulder M, Gibb I, Hill N, Aspley S, et al. A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. Ann Rheum Dis. 2011; 70:(9):1534–41.
    [Google Scholar]
  101. Meske DS, Lawal OD, Elder H, Langberg V, Paillard F, Katz N. Efficacy of opioids versus placebo in chronic pain: a systematic review and meta-analysis of enriched enrollment randomized withdrawal trials. J Pain Res. 2018;11:923–34.
    [Google Scholar]
  102. Krebs EE, Gravely A, Nugent S, Jensen AC, DeRonne B, Goldsmith ES, et al. Effect of opioid vs nonopioid medications on pain-related function in patients with chronic back pain or hip or knee osteoarthritis pain: The SPACE randomized clinical trial. JAMA. 2018; 319:(9):872–82.
    [Google Scholar]
  103. Attal N, Cruccu G, Baron R, Haanpää M, Hansson P, Jensen TS, et al. EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol. 2010; 17:(9):1113–e88.
    [Google Scholar]
  104. NeuropathicPain: The Pharmacological Management of Neuropathic Pain in Adults in Non-specialist Settings. London: © 2013, National Institute for Health and Care Excellence; 2013 Nov.
  105. Mu A WE, Moulin DE, Clarke H. Pharmacologic management of chronic neuropathic pain: Review of the Canadian Pain Society consensus statement. Can Fam Physician. 2017; 63:(11):844–52.
    [Google Scholar]
  106. Julia Oxley KET, Tim Daniel, Mike McHugh, Nick Willmot. Leicestershire Medicines Strategy Group. Guideline for treating patients with neuropathic pain. May 2009.
    [Google Scholar]
  107. Agarwal N, Joshi M. Effectiveness of amitriptyline and lamotrigine in traumatic spinal cord injury-induced neuropathic pain: a randomized longitudinal comparative study. Spinal Cord. 2017; 55:(2):126–30.
    [Google Scholar]
  108. Finnerup NB, Sindrup SH, Jensen TS. The evidence for pharmacological treatment of neuropathic pain. Pain. 2010; 150:(3):573–81.
    [Google Scholar]
  109. Gilron I, Tu D, Holden RR, Jackson AC, DuMerton-Shore D. Combination of morphine with nortriptyline for neuropathic pain. Pain. 2015; 156:(8):1440–8.
    [Google Scholar]
  110. Hempenstall K, Nurmikko TJ, Johnson RW, A'Hern RP, Rice AS. Analgesic therapy in post-herpetic neuralgia: a quantitative systematic review. PLoS Med. 2005; 2:(7):e164.
    [Google Scholar]
  111. Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ. Amitriptyline for neuropathic pain in adults. Cochrane Database Syst Rev. 2015; 2015:(7):CD008242.
    [Google Scholar]
  112. Saarto T, Wiffen PJ. Antidepressants for neuropathic pain. Cochrane Database Syst Rev. 2007(4):CD005454.
    [Google Scholar]
  113. Calandre EP, Rico-Villademoros F, Galán J, Molina-Barea R, Vilchez JS, Rodriguez-Lopez CM, et al. Quetiapine extended-release (Seroquel-XR) versus amitriptyline monotherapy for treating patients with fibromyalgia: a 16-week, randomized, flexible-dose, open-label trial. Psychopharmacology (Berl). 2014; 231:(12):2525–31.
    [Google Scholar]
  114. Moore RA, Derry S, Aldington D, Cole P, Wiffen PJ. Amitriptyline for neuropathic pain and fibromyalgia in adults. Cochrane Database Syst Rev. 2012;12:CD008242.
    [Google Scholar]
  115. Liu WQ, Kanungo A, Toth C. Equivalency of tricyclic antidepressants in open-label neuropathic pain study. Acta Neurol Scand. 2014; 129:(2):132–41.
    [Google Scholar]
  116. Rowbotham MC, Reisner LA, Davies PS, Fields HL. Treatment response in antidepressant-naïve post-herpetic neuralgia patients: double-blind, randomized trial. J Pain. 2005; 6:(11):741–6.
    [Google Scholar]
  117. Rheker J, Rief W, Doering BK, Winkler A. Assessment of adverse events in clinical drug trials: Identifying amitriptyline's placebo- and baseline-controlled side effects. Exp Clin Psychopharmacol. 2018; 26:(3):320–6.
    [Google Scholar]
  118. Sindrup SH, Bach FW, Madsen C, Gram LF, Jensen TS. Venlafaxine versus imipramine in painful polyneuropathy: a randomized, controlled trial. Neurology. 2003; 60:(8):1284–9.
    [Google Scholar]
  119. Rowbotham MC, Goli V, Kunz NR, Lei D. Venlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study. Pain. 2004; 110:(3):697–706.
    [Google Scholar]
  120. Vranken JH, Hollmann MW, van der Vegt MH, Kruis MR, Heesen M, Vos K, et al. Duloxetine in patients with central neuropathic pain caused by spinal cord injury or stroke: a randomized, double-blind, placebo-controlled trial. Pain. 2011; 152:(2):267–73.
    [Google Scholar]
  121. Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015; 14:(2):162–73.
    [Google Scholar]
  122. Hearn L, Derry S, Phillips T, Moore RA, Wiffen PJ. Imipramine for neuropathic pain in adults. Cochrane Database Syst Rev. 2014; 2014:(5):CD010769.
    [Google Scholar]
  123. Sultan A, Gaskell H, Derry S, Moore RA. Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials. BMC Neurol. 2008;8:29.
    [Google Scholar]
  124. Gahimer J, Wernicke J, Yalcin I, Ossanna MJ, Wulster-Radcliffe M, Viktrup L. A retrospective pooled analysis of duloxetine safety in 23,983 subjects. Curr Med Res Opin. 2007; 23:(1):175–84.
    [Google Scholar]
  125. Rintala DH, Holmes SA, Courtade D, Fiess RN, Tastard LV, Loubser PG. Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury. Arch Phys Med Rehabil. 2007; 88:(12):1547–60.
    [Google Scholar]
  126. Gordh TE, Stubhaug A, Jensen TS, Arnèr S, Biber B, Boivie J, et al. Gabapentin in traumatic nerve injury pain: a randomized, double-blind, placebo-controlled, cross-over, multi-center study. Pain. 2008; 138:(2):255–66.
    [Google Scholar]
  127. Vranken JH, Dijkgraaf MG, Kruis MR, van der VegtMH, Hollmann MW, Heesen M. Pregabalin in patients with central neuropathic pain: a randomized, double-blind, placebo-controlled trial of a flexible-dose regimen. Pain. 2008; 136:(1–2):150–7.
    [Google Scholar]
  128. Siddall PJ, Cousins MJ, Otte A, Griesing T, Chambers R, Murphy TK. Pregabalin in central neuropathic pain associated with spinal cord injury: a placebo-controlled trial. Neurology. 2006; 67:(10):1792–800.
    [Google Scholar]
  129. Kim JS, Bashford G, Murphy TK, Martin A, Dror V, Cheung R. Safety and efficacy of pregabalin in patients with central post-stroke pain. Pain. 2011; 152:(5):1018–23.
    [Google Scholar]
  130. Baron R, Freynhagen R, Tölle TR, Cloutier C, Leon T, Murphy TK, et al. The efficacy and safety of pregabalin in the treatment of neuropathic pain associated with chronic lumbosacral radiculopathy. Pain. 2010; 150:(3):420–7.
    [Google Scholar]
  131. Gimbel JS, Richards P, Portenoy RK. Controlled-release oxycodone for pain in diabetic neuropathy: a randomized controlled trial. Neurology. 2003; 60:(6):927–34.
    [Google Scholar]
  132. Huse E, Larbig W, Flor H, Birbaumer N. The effect of opioids on phantom limb pain and cortical reorganization. Pain. 2001; 90:(1–2):47–55.
    [Google Scholar]
  133. Eisenberg E, McNicol ED, Carr DB. Efficacy and safety of opioid agonists in the treatment of neuropathic pain of nonmalignant origin: systematic review and meta-analysis of randomized controlled trials. JAMA. 2005; 293:(24):3043–52.
    [Google Scholar]
  134. Raja SN, Haythornthwaite JA, Pappagallo M, Clark MR, Travison TG, Sabeen S, et al. Opioids versus antidepressants in post-herpetic neuralgia: a randomized, placebo-controlled trial. Neurology. 2002; 59:(7):1015–21.
    [Google Scholar]
  135. Watson CP, Babul N. Efficacy of oxycodone in neuropathic pain: a randomized trial in post-herpetic neuralgia. Neurology. 1998; 50:(6):1837–41.
    [Google Scholar]
  136. Watson CP, Moulin D, Watt-Watson J, Gordon A, Eisenhoffer J. Controlled-release oxycodone relieves neuropathic pain: a randomized controlled trial in painful diabetic neuropathy. Pain. 2003; 105:(1–2):71–8.
    [Google Scholar]
  137. Cooper TE, Chen J, Wiffen PJ, Derry S, Carr DB, Aldington D, et al. Morphine for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017; 5:(5):CD011669.
    [Google Scholar]
  138. Portenoy RK, Farrar JT, Backonja MM, Cleeland CS, Yang K, Friedman M, et al. Long-term use of controlled-release oxycodone for non-cancer pain: results of a 3-year registry study. Clin J Pain. 2007; 23:(4):287–99.
    [Google Scholar]
  139. Saxena AK, Nasare N, Jain S, Dhakate G, Ahmed RS, Bhattacharya SN, et al. A randomized, prospective study of efficacy and safety of oral tramadol in the management of post-herpetic neuralgia in patients from north India. Pain Pract. 2013; 13:(4):264–75.
    [Google Scholar]
  140. Duehmke RM, Derry S, Wiffen PJ, Bell RF, Aldington D, Moore RA. Tramadol for neuropathic pain in adults. Cochrane Database Syst Rev. 2017; 6:(6):CD003726.
    [Google Scholar]
  141. Almehlisi A, Tainter C. Emergency department pain management: beyond opioids. Emerg Med Pract. 2019; 21:(11):1–24.
    [Google Scholar]
  142. Abu-Ashour W, Twells L, Valcour J, Randell A, Donnan J, Howse P, et al. The association between diabetes mellitus and incident infections: a systematic review and meta-analysis of observational studies. BMJ Open Diabetes Res Care. 2017; 5:(1):e000336.
    [Google Scholar]
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  • Article Type: Review Article
Keyword(s): acute painanalgesicschronic painneuropathic pain and pain management
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