Primary amelanotic melanoma of the male urethra: A rare entity and diagnostic challenge

Shahryar Zeighami; Mohammmdreza Soltani; Fatemeh Khajeh; Ali Ariafar; Zahra Jahanabadi; Behnoosh Miladpour; Nima Naghdi-sede

doi:10.5339/qmj.2020.11

ISSN: 0253-8253
EISSN: 2227-0426

oa Primary amelanotic melanoma of the male urethra: A rare entity and diagnostic challenge
Authors: Shahryar Zeighami¹, Mohammmdreza Soltani², Fatemeh Khajeh³, Ali Ariafar⁴, Zahra Jahanabadi⁵, Behnoosh Miladpour⁶, Nima Naghdi-sede⁷
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Affiliations: ¹ Uro-oncologist, Assistant Professor, Urology Department, Shiraz University of Medical Sciences, Shiraz, Iran ² Urologist, Uro-oncology Fellowship Student, Shiraz University of Medical Sciences, Urology Department, Fasa, Iran ³ athologist, Professor Assistant, Fasa University of Medical Sciences, Pathology Department, Fasa, Iran ⁴ Uro-oncologist, Professor Assistant, Urology Oncology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ⁵ Urologist, Professor Assistant, Urology Department, Shiraz University of Medical Sciences, Shiraz, Iran ⁶ Clinical Biochemist, Professor Assistant, Fasa University of Medical Sciences, Fasa, Iran ⁷ Urologist, Uro-oncology Fellowship Student, Shiraz University of Medical Sciences, Urology Department, Shiraz, Iran
Source: Qatar Medical Journal, Volume 2020, Issue 1, Mar 2020,
DOI: https://doi.org/10.5339/qmj.2020.11
- Received: 14 June 2019
- Accepted: 01 December 2019
- Published online: 02 April 2020

Abstract

Malignant melanoma (melanoma) is a tumor of melanocytes that usually presents as cutaneous lesions. While melanoma can infrequently appear as a primary tumor elsewhere in the body, it is extremely rare in the urethra and even rarer as amelanotic malignant melanoma. We report the case of a 66-year-old male who presented with painless gross hematuria and lower urinary tract obstructive symptoms in the recent 2 weeks prior to his visit to our clinic. History and physical examination, including external genital examination, abdominopelvic sonography, and urine culture, were not conclusive. Cystourethroscopy revealed a creamy pink fragile mass located in the anterior proximal urethra that extended to the mid portion. Pathological examination of this lesion confirmed the diagnosis of amelanotic malignant melanoma using immunohistochemistry. Radical cystourethrectomy with ileal conduit was subsequently conducted. Although this tumor is extremely rare, urologists and pathologists should consider malignant melanoma as a diagnosis in patients with urethral tumor because of the likelihood of early metastasis and, consequently, poor prognosis. Complete surgical removal of the tumor and use of effective therapies can improve outcomes in these patients.

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Primary amelanotic melanoma of the male urethra: A rare entity and diagnostic challenge

Qatar Medical Journal 2020, 11 (2020); https://doi.org/10.5339/qmj.2020.11

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Article Type: Research Article

Keyword(s): amelanotic, male urethra, malignant melanoma, melanoma and urethra

oa Primary amelanotic melanoma of the male urethra: A rare entity and diagnostic challenge

Abstract

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