1887
Volume 2012, Issue 2
  • ISSN: 0253-8253
  • EISSN: 2227-0426

Abstract

This is the first paper to evaluate the potency of the tuberculin skin test (TST) results in confirmed pulmonary tuberculosis in the developing country. Data was collected retrospectively from the tuberculosis (TB) treatment unit during the period from 1998 to 2004. All charts diagnosed as active tuberculosis based on positive sputum smear or culture with documented TST were reviewed. The standard TST was done by injecting o.1 ml of 5 international units subcutaneous RT 23 purified protein derivative (PPD) on volar surface of the right arm. There were 306 patients with confirmed active pulmonary tuberculosis, of which 58% were smear positive and 42% were smear negative but culture positive. Expatriates accounted for 81% (247) and male for 74% (225) of the patients. The mean TST was 18.5 mm with standard deviation of 7.54 mm. TST was less than 5 mm in 8.2% (25), 5–10 mm in 1.6% (5), 10–15 mm in 11.1% (34) and more than 15 mm in 79.1% (242). False negative (reaction less than 10 mm) was significantly higher in Qatar nationals (17% vs 8% in expatriates) and those with associated diseases (16.3% vs 7% without associated diseases). Although 9.8% of confirmed pulmonary tuberculosis had false negative TST, it remains a potent aide for epidemiological and diagnostic purposes and periodic assessment of this is highly recommended. In our community with BCG vaccination a reaction more than 10 mm should be considered positive.

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References

  1. Sbarbaro JA. Skin testing in the diagnosis of tuberculosis. Sem Resp Infect. 1986; 1:4:234238.
    [Google Scholar]
  2. Bass JB jr. Tuberculin skin test. In: Reichman LBHerschfield ES, eds. Tuberculosis a comprehensive international approachMarcel Dekker 1993; 7:139148.
    [Google Scholar]
  3. Al-Marri MRHA. Childhood tuberculosis in the state of Qatar: the effect of a limited expatriate screening programme on the incidence of tuberculosis. Int J Tuberc Lung Dis. june 2001; 5:91:17.
    [Google Scholar]
  4. World Health Organisation Tuberculosis Reasearch Office. Further studies of geographic variation in naturally acquired tuberculin sensitivity. Bull World Health Org. 1955; 22::63.
    [Google Scholar]
  5. Snell NJC. A comparison of Mantoux and tuberculin tine testing in a chest unit. Tubercle. 1979; 60::99.
    [Google Scholar]
  6. Cosemans J, Louwagic . Tuberculin reactivity in patients with sputum positive tuberculosis. Bull Int Union Tuberc. 1979; 54::155.
    [Google Scholar]
  7. Cruz A, Manalo F, Lopez J, Faraon A. Reactions of confirmed Tuberculosis patients to standard tuberculin test. Chest Dis. 1978; 11::27.
    [Google Scholar]
  8. MecMurry D, Echevirri A. Cell-mediated immunity in anergic patients with pulmonary tuberculosis. Am Rev Resp. 1978; 118:.
    [Google Scholar]
  9. Kim SJ, Hong YP, Bai GH, Lee EK, Lew WJ. Tuberculin PPD RT23: has it lost some of its potency? Int J Tuberc Lung Dis. 1998; 2:10:857860.
    [Google Scholar]
  10. Kim SJ, Hong YP, Bai GH, Lee EK, Lew WJ. The debate about the stability of PPD RT23 is not closed (comment). J Tuberc Lung Dis. 1998; 2:10:795796.
    [Google Scholar]
  11. Haslov K, Ponce de Leon Rosales S, Rangel Frausto S, Olesen Larsen S. Tuberculin PPd RT 23: still going strong. J Tuberc Lung Dis. 1998; 2:10:793795.
    [Google Scholar]
  12. Johnston RN, Ritchie RT, Murray IHF. Declining tuberculin sensitivity with advancing age. Br Med J. 1963; 11::720722.
    [Google Scholar]
  13. Nash DR, Douglass JF. Anergy in active pulmonary tuberculosis. Chest. 1980; 77::3234.
    [Google Scholar]
  14. Aziz S, Haq G. The Mantoux reaction in pulmonary tuberculosis. Tubercle. 1985; 66::133136.
    [Google Scholar]
  15. AlMarri M, AlQatami M, AlJanahi M. The Tuberculin Skin Test in Children with Tuberculosis in the state of Qatar. Qatar Med J. June 2002; 11:1:1922.
    [Google Scholar]
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  • Article Type: Research Article
Keyword(s): PPDpulmonaryQatartuberculin and tuberculosis
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